Browsing by Author "Ozcan, Alper"

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Castleman Disease: A Multicenter Case Series from Turkey
(2022) Gunduz, Eren; Kirkizlar, Hakki Onur; Umit, Elif Gulsum; Gulsaran, Sedanur Karaman; Ozkocaman, Vildan; Ozkalemkas, Fahir; Candar, Omer; Elverdi, Tugrul; Kucukyurt, Selin; Paydas, Semra; Ceneli, Ozcan; Karakus, Sema; Maral, Senem; Ekinci, Omer; Ipek, Yildiz; Kis, Cem; Guven, Zeynep Tugba; Akdeniz, Aydan; Celkan, Tiraje; Kucukdiler, Ayse Hilal Eroglu; Cagliyan, Gulsum Akgun; Sengoz, Ceyda Ozcelik; Karatas, Ayse; Bulduk, Tuba; Ozcan, Alper; Apak, Fatma Burcu Belen; Canbolat, Aylin; Kartal, Ibrahim; Oren, Hale; Toret, Ersin; Ozdemir, Gul Nihal; Ozturk, Sule Mine Bakanay; 35176839
Objective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved. The aim of this multicenter study was to evaluate all cases of CD identified to date in Turkey to set up a national registry to improve the early recognition, treatment, and follow-up of CD. Materials and Methods: Both adult (n=130) and pediatric (n=10) patients with lymph node or involved field biopsy results reported as CD were included in the study. Patients' demographic information, clinical and laboratory characteristics, imaging study results, treatment strategies, and clinical outcomes were evaluated retrospectively. Results: A total of 140 patients (69 male and 71 female) with a diagnosis of UCD (n=73) or MCD (n=67) were included. The mean age was 39 years in the UCD group and 47 years in the MCD group. Female patients were more common in the UCD group. The most common histological subtype was hyaline vascular for both UCD and MCD patients. Asymptomatic patients were more common in the UCD group. Anemia, elevations of acute phase reactants, and hypoalbuminemia were more common in the MCD group. The most commonly used treatment strategies for UCD were surgical excision, rituximab, and radiotherapy, respectively. All UCD patients were alive at a median of 19.5 months of follow-up. The most commonly used treatment strategies for MCD were methyl prednisolone, R-CHOP, R-CVP, and rituximab. Thirteen MCD patients had died at a median of 34 months of follow-up. Conclusion: This study is important in presenting the patient characteristics and treatment strategies for CD from Turkey, with the potential of increasing awareness about CD. Treatment data may help in making decisions, particularly in countries that do not have access to siltuximab. However, larger prospective studies are needed to make definitive conclusions.
Combination of Two Different Homozygote Mutations in Pompe Disease
(2016) Arslan, Alev; Poyrazoglu, Hatice Gamze; Kiraz, Aslihan; Ozcan, Alper; Isik, Halid; Ergul, Ayse Betuel; Mungan, Neslihan Onenli; Streubel, Berthold; Ceylaner, Serdar; Torun, Yasemin Altuner; https://orcid.org/0000-0003-4444-0027; 26946079; V-1112-2019
Pompe disease (OMIM no 232300) is an autosomal recessive inherited metabolic disorder, caused by glycogen accumulation in the lysosome due to deficiency of the lysosomal acid 03B1-glucosidase enzyme. Here we report the case of an 8-month-old girl of consanguineous Turkish parents, who was diagnosed with the infantile form of Pompe disease. Two different uncommon homozygote mutations (c.32-13T>G homozygote and c.1856G>A homozygote) were detected. The patient had a more progressive clinical course than expected. We emphasize the rare combination of genetic mutations in this Turkish family with Pompe disease.
Invasive Fungal Infections in Children with Acute Lymphoblastic Leukemia: Experience from a Reference University Hospital in Cappadocia
(2020) Yilmaz, Ebru; Erdogmus, Arda; Ozcan, Alper; Gorkem, Sureyya Burcu; Ceylan, Ozgur; Deniz, Kemal; Unal, Ekrem; Atalay, Mustafa Altay; Karakukcu, Musa; Koc, Ayse Nedret; Patiroglu, Turkan; 0000-0001-6910-7250; AAK-8276-2021
Invasive fungal infections (IFI) are an important cause of mortality and morbidity in patients with hematological malignancy. This study aims to investigate the incidence of IFI development, risk factors, the management of the infection in a pediatric patient group followed up with the diagnosis of acute lymphoblastic leukemia (ALL), and to share the experience obtained from a single center. Two hundred forty children monitored with the diagnosis of ALL in the pediatric hematology-oncology department of the Erciyes University Medical Faculty from January 2010 to September 2017 included in the study. A total of 30 (14 females and 14 males) IR attacks were diagnosed (12.5%) in the included patients with ALL, two of them having the attacks twice. Candida species were the dominant cause of infection (n= 17) and the rest (n= 8) had invasive Aspergillosis. Nineteen IFI attacks were assessed as proven, 6 as probable, and 5 as possible IFI. The most fungal infection was detected in blood culture (43.3%) followed by pulmonary involvement (40%). The most frequently used diagnostic methods were direct microscopic examination, histological examination, and cultures (66.6%). IFI-related mortality was 20%. IFI continues to be an important problem in pediatric patients with hematologic malignity. The 7 of the observed invasive Aspergillosis developed in non hepafiltered room. Treatment of neutropenic children in hepafiltered rooms decrease the risk of IFI. With careful assessment of the patients bearing risk factors for IFI development, early diagnosis and treatment will reduce morbidity and mortal