Browsing by Author "Ozbek, Namik Y."

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Effect of Maternal and Neonatal Interleukin-6-174 G/C Polymorphism on Preterm Birth and Neonatal Morbidity
(2018) Karakas, N. Mutlu; Ecevit, Ayse N.; Yalcin, Yaprak; Ozdemir, Beril; Verdi, Hasibe; Tekindal, M. Agah; Ozbek, Namik Y.; Tarcan, Aylin; Atac, Fatma B.; Haberal, Ali; 0000-0002-9337-9106; 0000-0003-4286-7086; 0000-0001-6857-0681; 0000-0002-4060-7048; 0000-0002-2232-8117; 0000-0003-0591-009X; 0000-0002-1486-7209; 0000-0001-6868-2165; 28279124; ABB-4078-2020; AAX-3831-2020; HPC-6496-2023; U-9270-2018; AAJ-4616-2021; ABG-9940-2020; AAI-9331-2021; ABG-9966-2020
Objective: The aim of this study was to analyze maternal and neonatal interleukin 6 (IL-6) (-174 G/C) polymorphism and to determine effect on preterm birth and neonatal morbidity. Study Design: One hundred and sixty-four mothers (100 term births, 64 preterm births) and 183 newborn infants who were 100 healthy term and 83 preterm babies followed in newborn intensive care units were evaluated. PCR-RFLP was performed for IL-6 (-174 G/C) genotyping. Results: The rate of GG genotype in mothers of term and preterm infants were 54% (n = 54/100), 75% (n = 48/64), respectively (p>.05) and the rate of GC+CC genotype was 46% (n = 46/100) and 25% (n = 16/64) in mothers giving term and preterm birth (PTB), respectively (p<.05). Additionally, the rate of GG genotype was 65% (n = 65/100) and 81.9% (n = 68/83) in term infants and preterm infants, respectively. GC+CC genotype was 35% (n = 35/100) in term infants and 18.1% (n = 15/83) in preterm infants (p<.05). The effect of IL-6 (-174) GC+CC genotype on PTB was statistically significant. Conclusion: The IL-6 174 G/C gene polymorphism was significantly different between mothers who were giving to term and preterm birth. The presence of polymorphism is protective against preterm birth and was not associated with neonatal outcome.
Posterior Reversible Encephalopathy Syndrome in Childhood Hematological/Oncological Diseases: Multicenter Results
(2021) Bilir, Ozlem A.; Dikme, Gurcan; Malbora, Baris; Evim, Melike S.; Sivis, Zuhal O.; Tufekci, Ozlem; Bahadir, Aysenur; Karaman, Serap; Vural, Sema; Bayhan, Turan; Yarali, Husniye N.; Celkan, Tiraje; Ozbek, Namik Y.; 33060391
The aim of the study was to analyze the characteristics of posterior reversible encephalopathy syndrome (PRES) cases treated at 10 different institutions in our country. Fifty-eight patients diagnosed with PRES were included in this study. The data of PRES cases from 10 departments of pediatric hematology/oncology were analyzed. The mean age of the patients at the time of diagnosis of PRES was 8.95 +/- 3.66 years. Most patients (80.4%) had a primary diagnosis of acute leukemia. Patients received chemotherapy (71.4%) and/or used steroids within 14 days before the diagnosis of PRES (85.7%). Hypertension was found in 83.9% of the patients. Twenty-six patients had infections and 22 of them had febrile neutropenia. The most common electrolyte disorders were hypocalcemia, hypomagnesemia, and hypopotassemia. Six patients had tumor lysis syndrome and 4 had inappropriate antidiuretic hormone syndrome. Magnetic resonance imaging was used for diagnosis in all patients. The most commonly involved regions by magnetic resonance imaging were occipital (58%), parietal (51%), and frontal lobes (45%), respectively. Twenty-five patients required intensive care and 7 patients were intubated. In conclusion, PRES may develop during the follow-up and treatment of hematological diseases. In addition to steroid and intense combined chemotherapies, immunosuppressive agents and hypertension are also factors that may be responsible for PRES.
Successful Bone Marrow Transplantation After Orthotopic Liver Transplantation in A Child With Familial Hemophagocytic Lymphohistiocytosis
(2018) Aksu, Tekin; Olcay, Lale; Ozcay, Figen; Ozbek, Namik Y.; https://orcid.org/0000-0002-5684-0581; https://orcid.org/0000-0002-5214-516X; AAK-3548-2021; ABG-5684-2020