Browsing by Author "Ocal, S."

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    The effect of helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia : a retrospective single center research
    (2020) Suna, N.; Etik, D.; Ocal, S.; Gunduz, C.; Acikgoz, A.; Bildik, I; Gursoy, A.; Kasgoz, I; Tuleylioglu, H.; Boyacioglu, A.; 0000-0003-3719-9482; 0000-0002-4724-0728; 0000-0001-6234-7788; 33094583; ABH-4817-2020; AAJ-4707-2021; AAI-8822-2021
    Background and study aims : Gastric cancer (GC) is one of the major causes of cancer-related deaths worldwide. Helicobacter pylori (Hp) plays an important role in gastric carcinogenesis by inducing precancerous changes such as atrophic gastritis (AG) and intestinal metaplasia (IM). In our study, we aim to compare the grade of AG and IM before and after Hp eradication in patients who underwent esophagogastroduodenoscopy (EGD) in our center. Patients and methods : The data of 40.060 patients who underwent EGD for various reasons in our Endoscopy Unit between June 2011 and November 2017 were retrospectively evaluated. The grade of AG and IM before and after Hp eradication of patients meeting the study criteria were compared with each other. In addition, these findings were compared using OLGA and OLGIM staging systems. Results : A total of 175 patients, 89 (50.9%) women and 86 (49.1%) men, were included in the study. The mean age was 55 +/- 12 years. The mean time between two EGD examinations was 38 +/- 14 months. Significant improvement was observed in the grade of AG on corpus and antrum after Hp eradication (P=0.000, P=0.008). In the corpus and antrum, the grade of IM was regressed but this was not significant (P=0.80 and P=0.370 respectively). There was a decrease in OLGA stages after Hp eradication (P=0.000). There was also a reduction in the OLGIM stages, but this was not significant(P=0.341). Conclusion: Our study demonstrates that Hp eradication may reduce the risk of developing GC by providing an improvement in AG and IM which are precancerous changes in GC.
  • No Thumbnail Available
    Item
    Is There Any Association Between Irritable Bowel Syndrome Subgroups and Autonomous Dysfunction
    (2016) Yildirim, A. E.; Korkmaz, M.; Altun, R.; Sandikci, S. C.; Ocal, S.; Selcuk, H.; https://orcid.org/0000-0002-4386-9297; https://orcid.org/0000-0002-9333-782X; https://orcid.org/0000-0001-5921-8029; https://orcid.org/0000-0003-3719-9482; https://orcid.org/0000-0002-8445-6413; 27097952; AAG-6561-2020; AAM-1330-2020; AAE-7267-2021; ABH-4817-2020; AAJ-6976-2021
    OBJECTIVE: Irritable bowel syndrome (IBS) is a common functional intestinal disorder. Although there are marked improvements in the conceptualization of IBS pathophysiology in brain-intestinal interaction disorder, there is no definite consensus in the role of autonomic dysfunction (AD) in disease development and symptom progression. The aim of this study was to evaluate autonomous dysfunction in IBS subgroups. PATIENTS AND METHODS: A total of 50 patients and 49 healthy controls were included. IBS subgroup types and demographic characteristics of patients were recorded. AD investigations were made up of parasympathetic and sympathetic tests. RESULTS: There was no statistically significant difference was determined between the groups in accordance to demographic characteristics such as age, gender, BMI and resting heart rate (p > 0.05). Three parasympathetic and one sympathetic autonomic neuropathy tests were found significantly different (respectively p < 0.001, p = 0.001, p = 0.016, p < 0.001, p = 0.375). There were significant decreases in parasympathetic tests in IBS-C patients; however, in the control group, there were significant decreases in sympathetic tests when compared with IBS-D patients (p < 0.001). The severity of AD in IBS-C subgroup was more pronounced than the IBS-D subgroup. No correlation was determined between dysautonomia and disease duration (p > 0.05). CONCLUSIONS: AD may have a role in IBS pathophysiology. Deteriorat ion of the autonomous system not only affects the gastrointestinal system but also other systems including the cardiovascular system. Patients may also be susceptible to more diverse problems.
  • No Thumbnail Available
    Item
    Mucosal Healing and Deep Remission Rates with Azathioprine in Inflammatory Bowel Disease?
    (2018) Dagli, U.; Etik, D. Ozer; Demir, N.; Ocal, S.; Selcuk, H.; Hilmioglu, F.; Boyacioglu, S.; 0000-0002-4724-0728; 0000-0003-0664-0976; 0000-0002-8445-6413; 0000-0002-6440-5686; 0000-0002-9370-1126; 0000-0003-3719-9482; AAJ-4707-2021; S-4068-2018; AAJ-6976-2021; AAJ-4437-2021; AAE-7637-2021; ABH-4817-2020