Browsing by Author "Muratli, Asli"

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Interrecurrent nerve anastomosis with free nerve graft transposition in rabbits
(2017) Muratli, Asli; Calik, Bulent; Engin, Omer; Kulan, Can Ahmet; Topcu, Buket; Karaman, Kerem; Ipekci, Fuat; Yildirim, Gokce Aksoy; Unver, Mutlu
Objective: In this experimental study, we aimed to observe the effect of inter-recurrent free nerve graft transposition performed after iatrogenic transection of the recurrent laryngeal nerve on the improvement of vocal cord function in rabbits. Methods: The study consisted of 2 groups as the experimental, and control groups each containing 8 rabbits. The right recurrent nerve was transected both in the control and experiment groups. Inter-recurrent free nerve graft transposition using sural nerve was performed with end-to-side anastomosis in the experimental group whereas in the control group, nerve reconstruction was not performed. Results: After the 3rd postoperative month, the right vocal cord activity was recorded in the experimental group using videolaryngoscopy (VLS) and intramuscular electromyography (EMG). In contrast to the control group, no vocal cord muscle atrophy was found during light microscopic examination in the rabbits of the experimental group. Discussion: Inter-recurrent free nerve graft transposition is an acceptable method which can be considered in patients with iatrogenic recurrent nerve transection.
Radioprotective Effects of Amifostine, L-Carnitine and Vitamin E in Preventing Early Salivary Gland Injury due to Radioactive Iodine Treatment
(2019) Torun, Nese; Muratli, Asli; Serim, Burcu Dirlik; Ergulen, Alev; Altun, Gulay Durmus; https://orcid.org/0000-0002-5597-676X; 31989909; AAE-2718-2021
Objective: Standard treatment of differentiated thyroid cancer includes total thyroidectomy and high-dose Radioactive Iodine Therapy (RIT) for ablation of remnant thyroid tissue. When administered systemically, RIT can cause radiation-induced damage in non-targeted normal tissues. The aim of the present study was to compare the protective effects of amifostine (AMI), L-Carnitine (LC), and Vitamin E (EVIT) against high dose radioactive iodine treatment induced Salivary Gland (SG) damage using SG scintigraphy and histopathological examination. Methods: Forty adult guinea pigs were studied. Twenty guinea pigs receive 555-660 MBq (131)Iodine intraperitoneally (IP) to ablate the thyroid and impair the parenchymal function of the SGs. The animals were divided into eight groups as follows: (1) Group 1 (control): 1 mL IP PS (physiological saline); (2) Group 2: single dose of 200 mg/kg IP AMI one hour prior to 1 mL IP PS; (3) Group 3: 200 mg/kg IP LC and 1 mL IP PS for 10 days; (4) Group 4: 40 mg/kg intramuscular (IM) EVIT and 1 mL IP PS for 10 days; (5) Group 5: IP RIT after premedication; (6) Group 6: Single dose of 200 mg/kg IP AMI one hour prior to RIT and IP RIT after premedication; (7) Group 7: IP RIT after premedication and 200 mg/kg IP LC for 10 days starting one day before RIT; and (8) Group 8: IP RIT after premedication and 40 mg/kg IM EVIT for 10 days starting one day before RIT. Scintigraphy was performed 1 month after treatment. SGs were examined by light microscopy and a histopathological scoring system was used to assess the degree of SG damage. Results: There were significant differences in the body weight and thyroid hormone levels between the groups after treatment. Conclusion: The individual use of AMI, LC and EVIT for radioprotection yield different levels of protection against radioactive iodine treatment injury in SGs; however, none of the agents could provide absolute protection at the doses administered in this experimental model.