Browsing by Author "Muderrisoglu, H."
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Item Association between Serum Total Antioxidant Status and Coronary Microvascular Function in Idiopathic Dilated Cardiomyopathy(2015) Caliskan, M.; Gullu, H.; Erdogan, D.; Ozulku, M.; Kulaksizoglu, S.; Ciftci, O.; Muderrisoglu, H.; 0000-0002-9635-6313; 0000-0002-7613-2240; 0000-0003-2579-9755; 0000-0002-6463-6070; 24609797; JYO-9455-2024; AAG-8233-2020; AAI-8932-2021; IXD-5147-2023; A-7318-2017Background. Coronary microvascular impairment may cause myocardial ischemia and systolic dysfunction in patients with idiopathic dilated cardiomyopathy (IDC). Patients and methods. The study included 41 patients with IDC and 33 healthy control subjects. Serum total antioxidant status (TAS), serum interleukin (IL)-6 levels, and tumor necrosis factor (TNF)-alpha levels were assayed and coronary flow reserve (CFR) was measured in all subjects via echocardiography. Results. High-sensitivity C-reactive protein (hsCRP) levels were significantly higher in patients with IDC than in the control group (3.42 +/- 2.14 vs. 1.91 +/- 1.40, p=0.001). Serum TAS was statistically lower in patients with IDC than in controls (1.23 +/- 0.16 vs. 1.77 +/- 0.12, p<0.001). CFR was statistically and significantly lower in the IDC group (2.10 +/- 0.39 vs. 3.09 +/- 0.49, p<0.001). The IDC group was subsequently subdivided into two groups according to CFR values, as CFR >= 2 and CFR <2. HsCRP (4.30 +/- 2.42 vs. 2.58 +/- 1.42, p=0.01), TNF-alpha (16.67 +/- 8.08 vs. 10.97 +/- 1.63, p=0.01), and IL-6 (7.54 +/- 6.16 vs. 3.14 +/- 1.10, p=0.05) values were significantly higher in the CFR <2 group compared with the higher CFR group. TAS (1.3 +/- 0.16 vs. 1.14 +/- 0.10, p<0.001) was significantly lower in the CFR <2 group. CFR correlated significantly with hsCRP, TAS, red cell distribution width (RDW), IL-6, and TNF-alpha. Conclusion. Plasma proinflammatory cytokine levels are increased in patients with IDC. CFR was impaired as a reflection of impaired coronary microvascular dysfunction in association with increasing plasma proinflammatory cytokine levels and hsCRP levels.Item Association of Epicardial Adipose Tissue and Plasma Homocysteine with Metabolic Syndrome in Patients with Normal Coronary(2014) Balcioglu, A.; Durakoglugil, M.; Cicek, D.; Bal, U.; Boyaci, B.; Muderrisoglu, H.Item Determinants and Impact of New Persistent Atrial Fibrillation on Long-Term Outcome in Patients Receiving Cardiac Resynchronization Therapy(2014) Sade, L. E.; Atar, I.; Ozin, B.; Muderrisoglu, H.; https://orcid.org/0000-0003-3737-8595; https://orcid.org/0000-0002-9635-6313; AAQ-7583-2021; AAG-8233-2020Item Estimation Value of Prediction Plasma Osteopontin Levels in Patients Undergoing Percutaneous Coronary Intervention(2015) Yilmaz, K.; Bal, U. A.; Karacaglar, E.; Okyay, K.; Aydinalp, A.; Yildirir, A.; Muderrisoglu, H.; 0000-0001-8750-5287; 0000-0002-9635-6313; 0000-0001-6134-8826; 0000-0002-3761-8782; 0000-0002-2538-1642; 0000-0002-9446-2518; A-4947-2018; AAG-8233-2020; AAK-7355-2020; AAD-5841-2021; AAJ-1331-2021; ABI-6723-2020; AAK-4322-2021Item Evaluation of Left Ventricular Functions with Strain Echocardiography in Polycystic Ovary Syndrome Patients(2014) Aslan, G.; Aslan, R. C.; Sade, L. E.; Bal, U.; Onalan, G.; Zeyneloglu, H. B.; Kuscu, E.; Muderrisoglu, H.Item Impact of Weight Loss on Epicardial Fat and Carotid Intima Media Thickness After Laparoscopic Sleeve Gastrectomy: A Prospective Study(2018) Altin, C.; Erol, V; Aydin, E.; Yilmaz, M.; Tekindal, M. A.; Sade, L. E.; Gulay, H; Muderrisoglu, H.; https://orcid.org/0000-0002-3996-5681; https://orcid.org/0000-0003-3737-8595; https://orcid.org/0000-0002-0442-6178; https://orcid.org/0000-0003-0907-3647; https://orcid.org/0000-0002-9635-6313; https://orcid.org/0000-0002-2557-9579; 29571589; HGC-1839-2022; S-6973-2016; AAG-8233-2020; AAI-8276-2021; AAJ-6407-2021; AAQ-7583-2021Background and aims: Cardiovascular disease (CVD) is one of the leading causes of mortality in obese patients. We aimed to investigate the influence of significant weight loss following laparoscopic sleeve gastrectomy (LSG) on carotid intima media thickness (CIMT) and epicardial fat thickness (EFT) which are the independent predictors of subclinical atherosclerosis. Methods and results: Patients were recruited for standard indications. A total of 105 patients (79 women and 26 men) with the mean age of 43.61 +/- 12.42 were prospectively enrolled. On Bmode duplex ultrasound; the mean CIMT at the far wall of both left and right common carotid arteries were measured. EFT was measured on the free wall of the right ventricle at enddiastole from the parasternal long-axis view by standard transthorasic 2D echocardiography. Delta (Delta) values were obtained by subtracting sixth month values from the baseline values. Body mass index (BMI) was significantly reduced from 46.95 +/- 7.54 to 33.54 +/- 6.41 kg/m2 (p < 0.001) in sixth months after LSG. Both EFT and CIMT were significantly decreased after surgery (8.68 +/- 1.95 mm vs. 7.41 +/- 1.87 mm; p < 0.001 and 0.74 +/- 0.13 mm vs. 0.67 +/- 0.11 mm; p < 0.001 respectively). A significant correlation between Delta EFT and Delta MI (r = 0.431, p < 0.001) was shown. Delta CIMT is significantly correlated with Delta EFT, Delta BMI and Delta systolic blood pressure (r = 0.310, r = 0.285 and r = 0.231 respectively, p < 0.05 for all). In multivariate stepwise linear regression analysis; among variables only Delta BMI was the independent predictor of Delta EFT (beta = 153, p = 0.001). Conclusion: Early atherosclerotic structural changes may be reversed or improved by sustained weight loss after LSG in asymptomatic obese patients. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.Item Left Atrial Mechanics Predict Atrial Fibrillation in Patients After Cryptogenic Stroke(2018) Sade, L. E.; Colak, A.; Ciftci, O.; Can, U.; Kibaroglu, S.; Ozin, B.; Muderrisoglu, H.; 0000-0003-3737-8595; 0000-0001-8926-9142; 0000-0001-8689-417X; 0000-0002-3964-268X; 0000-0002-9635-6313; AAQ-7583-2021; W-5233-2018; AAJ-2999-2021; AAJ-2956-2021; AAG-8233-2020Item Relationship between Neutrophil-to-Lymphocyte Ratio and Impaired Myocardial Perfusion in Cardiac Syndrome X(2015) Okyay, K.; Yilmaz, M.; Yildirir, A.; Eroglu, S.; Sade, E.; Sahinarslan, A.; Aydinalp, A.; Muderrisoglu, H.; 0000-0001-8750-5287; 0000-0001-6134-8826; 0000-0002-3761-8782; 0000-0002-9635-6313; 0000-0003-3737-8595; 0000-0003-3055-7953; 26044235; A-4947-2018; AAK-7355-2020; AAD-5841-2021; ABG-1582-2021; AAG-8233-2020; AAQ-7583-2021OBJECTIVE: Myocardial tissue perfusion is decreased in patients with cardiac syndrome X (CSX). Systemic inflammation appears to be an important contributor to the diseased microvascular network of these patients. The neutrophil-to-lymphocyte ratio (NLR) is a surrogate marker of inflammation. Accordingly, we evaluated this biomarker concerning the microvascular circulation of CSX patients. PATIENTS AND METHODS: This study included 60 consecutive patients (54.1 +/- 7.8 years of age, 49 females) with CSX (typical chest pain, positive exercise stress test results, and normal coronary angiograms) and 60 consecutive age- and sex-matched control subjects. In all coronary territories, epicardial coronary flow was assessed by the Thrombolysis In Myocardial Infarction frame count (TFC) method, and myocardial tissue perfusion was assessed by the myocardial blush grade (MBG) method. Normal myocardial perfusion was accepted as an MBG score of 3 in all coronary territories. RESULTS: Patients with CSX had higher NLRs than those of control subjects (1.98 +/- 0.77 vs 1.72 +/- 0.55, respectively; p = 0.04). Among patients with CSX, those with impaired myocardial perfusion had higher NLRs than those with normal myocardial perfusion (2.13 +/- 0.82 vs 1.71 +/- 0.59, respectively; p = 0.028). There was a negative correlation between the NLR and total MBG score (p = 0.027, r = -0.29). Logistic regression analysis showed that the NLR was an independent and negative predictor of myocardial tissue perfusion (p = 0.027; Beta, -1.057; odds ratio, 2.878; 95% confidence interval, 1.129-7.335). CONCLUSIONS: Patients with CSX have high NLRs, and inflammation seems to be associated with distorted myocardial perfusion in these patients.Item Right Ventricular Adaptation and Subclinical Damage by Echocardiography in Heart Transplantation Recipients: Insights From Myocardial Work Index(2022) Sade, L. E.; Colak, A.; Sezgin, A.; Donal, E.; Butcher, S. C.; Pirat, B.; Eroglu, S.; Ozdemir, H.; Muderrisoglu, H.; 0000-0001-8258-8802; AED-3780-2022Item The Role of Left Atrial Strain and Procollajen Type III N-Terminal Peptide Levels in Determination of Paroxysmal Atrial Fibrillation in Ischemic Stroke(2017) Eroglu, S.; Akyol, K.; Ciftci, E.; Sade, E.; Muderrisoglu, H.; 0000-0003-2122-1016; 0000-0002-9635-6313; ABG-1582-2021; AAI-8830-2021; AAG-8233-2020Item A Single Centre Retrospective Clinicopathologic Study of Endomyocardial Biopsies After Heart Transplantation at Baskent University Hospital in Ankara 1993-2014(2014) Terzi, A.; Sezgin, A.; Tunca, M. Z.; Deniz, E.; Ayva, E. S.; Haberal, N.; Muderrisoglu, H.; Ozdemir, B. H.; https://orcid.org/0000-0002-1225-1320; https://orcid.org/0000-0001-9852-9911; https://orcid.org/0000-0002-9635-6313; https://orcid.org/0000-0002-7528-3557; F-7546-2013; AAK-4587-2021; AAG-8233-2020; X-8540-2019Item Ti Mapping of the Right Ventricle in Heart Transplant Recipients: How Does It Correlate with Endomyocardial Biopsy Findings?(2022) Sade, L. E.; Colak, A.; Duzgun, S. A.; Hazirolan, T.; Sezgin, A.; Ozdemir, H.; Eroglu, S.; Pirat, B.; Muderrisoglu, H.