Browsing by Author "Misir, Emre"

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Dimensional Characteristics of Persistent Negative Symptoms in Schizophrenia and Their Relationships with Schizotypy in First-Degree Relatives
(2023) Cengisiz, Cengiz; Misir, Emre; 37646862; JBS-4683-2023; JBS-4683-2023
Purpose of the articleSchizophrenia with persistent negative symptoms (PNS) may have different characteristics regarding negative symptom dimensions and heritability patterns. This study aimed to investigate the dimensional characteristics of PNS and their relationships with schizotypal features in first-degree relatives (FDRs).Materials and methodsThe study included 142 patients, 142 FDRs, and 71 healthy controls (HC). Patients were evaluated with the Positive and Negative Symptom Scale (PANSS), Brief Negative Symptom Scale (BNSS), Calgary Depression Scale for Schizophrenia (CDSS), and Simpson-Angus Scale (SAS). Schizotypy Personality Questionnaire was applied to FDR and HC groups. Clinical symptoms were compared between primary-PNS, secondary-PNS, and non-PNS groups. In addition, schizotypy scores were compared between FDRs and HCs. Then, the relationship between the symptoms of the patients in the PNS group and the schizotypy scores of their relatives was evaluated by multiple regression analysis.ResultsAll negative symptom dimension scores were similar in primary-PNS and secondary-PNS and lowest in non-PNS. PNS-FDR had higher in all schizotypy scores than non-PNS-FDR and HC, except for lack of close friends and social anxiety. In the PNS group, positive symptom severity and PANSS experiential deficit scores significantly predicted positive and negative schizotypy scores in relatives. Negative schizotypy was associated with asociality.ConclusionsThe PNS is likely a subtype in which the genetic basis of negative symptoms is stronger and is associated with genetic abnormalities shared by positive and negative schizotypy dimensions in relatives. Family-based genetic studies will be beneficial in enlightening the genetic etiology of PNS.
The effects of catechol-O-methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta-analysis
(2022) Misir, Emre; Ozbek, Mutlu Muhammed; Halac, Eren; Turan, Serkan; Alkas, Gokce Elif; Ciray, Remzi Ogulcan; Ermis, Cagatay; 0000-0001-8953-1171; 35642295; AAF-3209-2021
The catechol-O-methyltransferase (COMT) gene is thought to have an important role in the etiopathogenesis of schizophrenia, but there are conflicting results regarding its role in clinical presentation. We aimed to elucidate the relationship between the single nucleotide polymorphisms (SNPs) in the COMT gene and the severity of positive and negative symptoms. In order to investigate the relationship, the PubMed, PubMed Central, Scopus, and Cochrane CENTRAL databases were screened for eligible articles. Thirty-eight studies, including 4443 adult patients with schizophrenia, were included in the quantitative analyses, and four studies were qualitatively assessed. Quantitative analyses were performed for acutely ill and clinically stable patient subgroups regarding the different genotypes of rs4680 SNP. Our results showed that the severity of negative symptoms was higher in patients who were rs4680 Met homozygous compared to Val/Met heterozygotes only in acutely ill samples. There was no other significant difference between genotypes. Meta-regression did not reveal any significant moderator effect on the difference in negative symptoms. General psychopathology, positive, negative, and total psychotic symptom levels also were similar between Val homozygotes and Met carriers. Nonetheless, there are some limitations in the study. First, SNPs except for rs4680 were under-researched because of the limited number of studies. Second, high heterogeneity across studies was the main concern. Our results suggested that the COMT rs4680 Met allele was associated with higher levels of negative symptoms within acutely ill patients. Future studies should focus on specific patient subgroups to reveal the moderating effects of SNPs.
Functional Connectivity In Rumination: A Systematic Review Of Magnetic Resonance Imaging Studies
(Başkent Üniversitesi, 2024-02-18) Misir, Emre; Alici, Yasemin Hosgoren; Kocak, Orhan Murat
IntroductionRumination, defined as intrusive and repetitive thoughts in response to negative emotions, uncertainty, and inconsistency between goal and current situation, is a significant risk factor for depressive disorders. The rumination literature presents diverse findings on functional connectivity and shows heterogeneity in research methods. This systematic review seeks to integrate these findings and provide readers diverse perspectives.MethodFor this purpose, the literature on functional connectivity in rumination was reviewed according to the PRISMA guidelines. Regional connectivity and network connectivity results were scrutinized according to the presence of depression, research methods, and type of rumination. After screening 492 articles, a total of 36 studies were included.ResultsThe results showed that increased connectivity of the default mode network (DMN) was consistently reported. Other important findings include alterations in the connectivity between the DMN and the frontoparietal network and the salience network (SN) and impaired regulatory function of the SN. Region-level connectivity studies consistently show that increased connectivity between the posterior cingulate cortex and the prefrontal cortex is associated with rumination, which may cause the loss of control of the frontoparietal network over self-referential processes. We have seen that the number of studies examining brooding and reflective rumination as separate dimensions are relatively limited. Although there are overlaps between the connectivity patterns of the two types of rumination in these studies, it can be thought that reflective rumination is more associated with more increased functional connectivity of the prefrontal cortex.ConclusionsAlthough there are many consistent functional connectivity outcomes associated with trait rumination, less is known about connectivity changes during state rumination. Relatively few studies have taken into account the subjective aspect of this thinking style. In order to better explain the relationship between rumination and depression, rumination induction studies during episode and remission periods of depression are needed.
'Ilie effects of working and living conditions of physicians on burnout level and sleep quality
(2021) Misir, Emre; 34726667
Background: Burnout is a multidimensional syndrome associated with intense working conditions and negative psychosocial factors in physicians. The purpose of this study is to investigate the effects of living and working con-ditions of physicians on burnout level and sleep quality in Turkey. Metbods: In this internet-based questionnaire study, 1053 physicians [General Practitioners (n=233); Basic Medical Sciences (n=26); Internal Medical Sciences (n=530), and Surgery Sciences (n=264)J were included in the study, filling the forms consisting of study conditions, Maslach Burnout Inventory (MBI) and the Pittsburgh Sleep Quality Index (PSQI) questions. Results: Negative occupational factors such as physicians having a night shift, high number of patients who are cared for daily, short ex-amination period, low financial gain, exposure to violence, and mobbing were associated with poor sleep quality and burnout. Factors such as being subjected to violence, mobbing, and age are predictive of increasing burnout in women. Working on night shifts or being on-call were associated with all aspects of burnout. The proportion of those with poor sleep quality was significantly higher in those working night shifts (74.6%) than those working daytime shifts (67.2%) and those who were exposed to violence (75.1%) compared to those who were not exposed to violence (43.2%) (p=0.013, p<0.001, respectively). Conclusions: Impaired sleep quality, violence, mobbing, young age, excessive night shifts, short examination period, and low income may play a role in physician burnout. Our study data suggest that it is important to improve physicians' unfavorable working conditions and to prevent violence against burnout.
Sleep quality impairments in schizophrenia and bipolar affective disorder patients continue during periods of remission: a case-controlled study
(2022) Hacimusalar, Yunus; Karaaslan, Ozgul; Misir, Emre; Amuk, Ozge Ceren; Hacimusalar, Goknur; 35662968
OBJECTIVE: Bipolar disorder (BD) and schizophrenia are chronic psychiatric disorders in which sleep disorders are commonly seen. In mental disorders, residual symptoms may persist even if symptoms are greatly reduced overall. The aim of this study was to compare the sleep quality of schizophrenia and BD patients in remission with that of healthy controls. METHODS: Forty-three patients with schizophrenia, 46 BD patients in remission for at least 3 months, and 51 healthy controls were included the study. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Young Mania Rating Scale (YMRS) and Pittsburgh Sleep Quality Index (PSQI) were administered to all participants and the Positive and Negative Syndrome Scale (PANSS) was administered to patients with schizophrenia. RESULTS: Poor sleep quality was more frequent in the patient groups than the control group (p=0.009). PSQI score was positively correlated with duration of disease (r=0.236; p=0.026), number of cigarettes smoked per day (r=0.430; p<0.001), body mass index (r=0.189; p=0.025), and negatively correlated with duration of remission (r=-0.224; p=0.0359). CONCLUSION: Schizophrenia and BD patients in remission had worse sleep quality than a control group. Sleep quality was worst in the patients with schizophrenia. The severity of sleep disorder symptoms was positively associated with disease duration and negatively associated with duration of remission. Schizophrenia and BD patients should be carefully evaluated for symptoms of sleep disorders even when they are in clinical remission and should be offered additional treatment for sleep disorder symptoms when necessary.
Validity and reliability study of the Turkish version of the male depression risk scale and the gender-sensi- tive scale
(2022) Misir, Emre; Batmaz, Sedat; Demir, Meral Oran
Objective: The aim of the present study was to inves-tigate the Turkish validity and reliability of the Male Depression Risk Scale (MDRS) and the Gender -Sensitive Depression Scale (GSDS). Method: 108 patients met the diagnostic criteria for major depres-sive disorder applied to Tokat Gaziosmanpasa University Faculty of Medicine and Yozgat City Hospital Psychiatry Clinic and 98 healthy controls were included in the study. All participants were given the MDRS, GSDS, and the Brief Symptom Inventory (BSI) self-report scales. Explanatory factor analysis, correlation analyzes, and Mann-Whitney U and t test were used for disciriminant-convergent validity. Internal consistency coefficient and item -total score correlations were calculated for reliability. ROC analysis was conducted to show how much the scales differentiates the patient and the healthy control group. Results: Three-factor solution was obtained for both scales. These factors are Alcohol, Substance and Depression for MDRS; Dysphoria-Irritability, Impulsivity-Shame, and Alcohol for GSDS. Item factor loads were between 0.347-0.893 in MDRS and 0.377-0.962 in GSDS. The scales have been shown to be valid in terms of convergent and discri-minant validity. At the same time, the scales were found to be reliable, and the internal consistency coefficients were 0.912 and 0.917 for MDRS and GSDS, respectively. The reliability of the subscales is also at an acceptable level. Subscale scores for both scales, except alcohol and substance dimensions, were significantly higher in women. The area under the curve was 0.847 for MDRS and 0.868 for GSDS in the ROC analysis. Conclusion: The analyses revelaed that Turkish forms of MDRS and GSDS were valid and reliable. Male-type depression symptoms were not specific to men, but the results pointed to a separate type in which externalizing symptoms are dominant. These scales are thought to be valuable and useful for studies to be conducted in our country with male -type depression.