Browsing by Author "McGill, Rita L."

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    Steroid Avoidance in Renal Transplant Patients Maintained on a Cyclosporine-based Protocol
    (2007-12) Ko, Tina Y; Julie A Haddy,; Sureshkumar, Kalathil K.; Breckenridge, Molly; Patel, Satish; Marcus, Richard J.; Sandroni, Stephen E.; McGill, Rita L.; Carpenter, Barbara J.; Nghiem, Dai D.
    Objective: The aim of this study was to analyze the effect of steroid avoidance, as compared with our pre-existing protocol that contained steroids, on renal allograft and patient survival. Secondary outcomes included body weight, diabetes, hyperlipidemia, and infection. Materials and Methods: This retrospective chart review of the results of steroid avoidance was performed in 169 patients who had undergone renal transplant between January 2000 and March 2002 and had received an immunosuppression regimen of cyclosporine, mycophenolate mofetil, and pred­nisone; and 148 patients who had undergone transplant between November 2002 and November 2004 who had received induction immuno­suppression with a steroid taper by postoperative day 4 and were maintained on cyclosporine and mycophenolate mofetil. Results: One-year allograft survival rates, rejection-free graft survival rates, and patient survival rates were 88%, 76%, and 97%, respectively, in the steroid-maintenance group compared with 90%, 74%, and 96%, respectively, in the steroid-avoidance group (P = NS). No differences were detected in multiple secondary variables related to the metabolic effects of steroid therapy. Conclusions: These data suggest that steroid avoidance can be performed safely and effectively in patients on a cyclosporine-based protocol of immuno­suppression. Longer follow-ups are suggested to determine the effects of limited steroid exposure on the metabolic profiles of patients.