Browsing by Author "Mazaris, Evangelos M."

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    Ethical Issues in Live Donor Kidney Transplant: Views of Medical and Nursing Staff
    (Başkent Üniversitesi, 2009-03) Mazaris, Evangelos M.; Papalois, Vassilios E.; Warrens, Anthony N.
    Objectives: The ongoing development of live donor kidney transplant has generated many ethical dilemmas. It is important to be aware of the attitudes of transplant professionals involved in this practice. Materials and Methods: An anonymous and confidential questionnaire was sent to 236 members of the medical and nursing staff of the West London Renal and Transplant Centre, to assess their views on the ethics of the current practice of live donor kidney transplant. Results: Of the 236 questionnaires, 108 (45.8%) were returned. Respondents considered live donor kidney transplant ethically acceptable between blood relatives (100%), nonblood relatives and friends (92.6%), and strangers (47.2%). Most respondents were willing to donate a kidney to a blood relative (92.6%) or a nonblood relative or friend (81.5%), and 12.0% were willing to donate to a stranger. Considering themselves as potential recipients if they had end-stage renal disease, most would accept a kidney from a blood relative (91.7%) or nonblood relative or friend (85.2%), while 44.5% would accept a kidney from a stranger. The highest number of respondents (43.5%) believed that the recipient should approach the potential donor. About one-third believed there should be no financial reward, not even compensation for expenses, for donors; 8% favored direct financial rewards for donors known to recipients, and 18% favored rewards for donors not known to recipients. Slightly more than half were in favor of accepting donors with mild to moderate medical problems. Conclusions: Live related and unrelated kidney donation are considered ethically acceptable procedures, and non-directed donation is gaining support among transplant professionals. A substantial minority favored direct financial rewards for donors, especially in the case of non-directed donation.
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    Hepatocyte Transplantation: A Review of Worldwide Clinical Developments and Experiences
    (Başkent Üniversitesi, 2005-06) Mazaris, Evangelos M.; Roussos, Christos Th.; Papalois, Vassilios E.
    Hepatocyte transplantation is a promising treatment for several liver diseases and can also be used as a “bridge” to liver transplantation in cases of liver failure. Although the first animal experiments with this technique began in 1967, it was first applied in humans in 1992. Clearly, the most important advantage of this treatment, compared with liver transplantation, is its simplicity, since no surgery is required for implantation of the cells. Much work has been done over the years to maximize the number of viable hepatocytes that can be isolated from a liver, to prepare the cells prior to transplantation so that the outcome will be more successful, and to identify the optimal site for implantation. We review these efforts along with the worldwide clinical experience with hepatocyte transplantation during the last 13 years.