Browsing by Author "Makay, Ozer"

Now showing 1 - 3 of 3

Efficacy of Simvastatin in Reducing Postoperative Adhesions After Thyroidectomy: An Experimental Study
(2017) Makay, Ozer; Isik, Dilek; Erol, Varlik; Yenisey, Cigdem; Kose, Timur; Icoz, Gokhan; Ertan, Yesim; Ozutemiz, Omer; Akyildiz, Mahir; 0000-0001-7693-641X; 27735220; ABH-3197-2021
Background: We aimed to investigate whether simvastatin had any impact on the prevention of adhesion formation after thyroidectomy in a rat model. Methods: This study was performed in 66 Wistar albino rats randomized into three experimental groups. A right hemithyroidectomy was carried out in all the rats. Simvastatin was administered locally at a dose of 0.5 mg/kg and 0.8 mg/kg. Control rats received a saline solution only. Changes during the 1st week, 1st month and 3rd month were evaluated. Efficacy of the treatment was assessed by using a scoring system. Results: The severity of adhesions in low-dose simvastatin group was significantly less than the control and high-dose groups during the 1st and 3rd month (p <. 05). In addition, adhesions were less in the high dose group during the 3rd month, when compared to the control group (p <. 05). Moreover, fibrosis and fibroblast scores, which represent adhesions, were significantly lower in low-dose and high-dose groups at 3rd month, compared to controls (p <. 05). Conclusions: We investigated the influence of simvastatin application on post-thyroidectomy adhesion formation in rats. Whether adhesions, causing technical difficulties during neck redo surgery, can be reduced by the use of simvastatin in human, needs to be studied.
Intraoperative neuromonitoring of the RLNs during TOETVA procedures
(2020) Erol, Varlik; Dionigi, Gianlorenzo; Barczynski, Marcin; Zhang, Daqi; Makay, Ozer; 32175253
Transoral endoscopic thyroidectomy by vestibular approach (TOETVA) is now being performed in increasing frequency and getting more and more attention. TOETVA is carried out through three incisions in the oral vestibular area. Thyroidectomy is performed endoscopically using conventional laparoscopic instruments, an energy based device and neuromonitoring instruments. Intraoperative neuromonitoring is one of the tools of utmost importance, used for navigation and confirmation of the functional integrity of the recurrent nerve during TOETVA. The aim of this study is to give information about the standards and technique of intraoperative neuromonitoring of the recurrent laryngeal nerves during TOETVA procedures. TOETVA is a safe technique with no visible scarring and hence resulting in an excellent cosmetic effect. We believe that neuromonitoring of the recurrent laryngeal nerves also minimizes the risk of nerve damage and is an essential safety component in this technique.
Portal Hyperfusion or Hepatic Venous Congestion: Which One Affects Kupffer Cell Function More?
(Başkent Üniversitesi, 2009-03) Firat, Ozgur; Yuzer, Yildiray; Kitapcioglu, Gul; Omur, Ozgur; Yilmaz, Funda; Makay, Ozer; Mutlukoca, Nadide
Objectives: Because of their effects on the liver parenchyma after surgery, portal hyperperfusion and hepatic venous congestion are challenging problems for hepatobiliary surgeons. However, the effects of those conditions on Kupffer cells have not been established. The aim of this study was to investigate the effects of vascular streams modified by portal hyperperfusion and hepatic venous congestion on Kupffer cell function. Materials and Methods: Thirty rats were allocated into 3 groups of 10 rats each and were subjected to right portal vein ligation to induce hyperperfusion in the left lobe of the liver (group 1), occlusion of the right hepatic vein to produce venous congestion (group 2), or sham operation (controls; group 3). After 72 hours, the right and left liver lobes of the subjects were submitted separately for scintigraphic and histopathologic evaluation, and the radiocolloid uptake per gram of liver tissue and the number of Kupffer cells per square millimeter were calculated. Results: The mean technetium-99m labeled sulfur colloid uptake values of the liver tissue per gram were 0.126 ± 0.038 for group 1, 0.106 ± 0.032 for group 2, and 0.110 ± 0.031 for group 3. Portal hyperperfusion significantly increased the technetium-99m labeled sulfur colloid uptake of the liver tissue per gram (P = .043). The mean number of Kupffer cells per square millimeter was calculated for each group as follows: 321 ± 094 × 10-6 for group 1, 369 ± 083 × 10-6 for group 2, and 355 ± 096 × 10-6 for group 3. Both vascular streams produced no significant effects on the number of Kupffer cells (P > .05). Conclusions: In this experimental model, portal hyperperfusion affected Kupffer cell function more than did hepatic venous congestion.