Browsing by Author "Lux, Karl Michael"

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    Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats
    (2022) Emre-Aydingoz, Selda; Lux, Karl Michael; Efe, Oguzhan Ekin; Topcu, Deniz Ilhan; Erdem, Saban Remzi; 0000-0001-7823-7620; 0000-0002-3243-7843; 0000-0002-1219-6368; 35993621; ABA-4291-2020; W-7908-2019; E-3717-2019
    The effect of rosuvastatin (Ros) on cognitive function and anxiety-like behaviour in ovariectomized rats were evaluated. Eighteen female Wistar rats (218-310g, 6-8 months old) were allocated into sham (n = 6), ovariectomy (Ovx, n = 6) or Ovx + Ros (up to eighth week n = 6, then n = 4) groups. Ros was administered at 20 mg/kg/day by oral gavage for 12 weeks. Behavioural tests were performed at 4, 8 and 12 weeks following Ovx. At 12weeks, Ovx group had significantly longer escape latency than the sham group at the first day of the four-day training period of the Morris Water Maze test (p < .01). In the Elevated Plus Maze test, Ovx group spent significantly more time in the closed arms than the sham group (p < .01), and this anxiety-like behavioural effect of Ovx was prevented by 12-weeks Ros treatment (p < .05). In conclusion, Ros prevents memory deficit and anxiety-like behaviour in the ovariectomized rats, a model for human surgical menopause.
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    POLYPHARMACY PREVALENCE AMONG GERIATRIC PATIENTS IN PRIMARY HEALTHCARE SETTINGS ACROSS TURKEY: A CROSS-SECTIONAL ANALYSIS THROUGH THE NATIONWIDE PRESCRIPTION INFORMATION SYSTEM
    (2020) Aydos, ToIga Resat; Emre Aydingoz, Selda; Lux, Karl Michael; Efe, Oguzhan Ekin; Isli, Fatma; Aksoy, Mesil; Kadidoi, Esma; 0000-0002-3243-7843; 0000-0002-1832-9336; 0000-0001-7823-7620; W-7908-2019; AAJ-7279-2020; ABA-4291-2020
    Introduction: Polypharmacy has become a common health problem as populations age. We aimed to determine the prevalence of chronic and cumulative polypharmacy in the geriatric population using primary healthcare services in Turkey. Materials and Methods: The electronic prescriptions ordered by family physicians across Turkey for geriatric patients (>= 6.5 years) in the Prescription Information System during 2018 were studied. Chronic polypharmacy criteria were proportion of patients who were given prescriptions containing >= 5 drugs four or more times during a year. Cumulative polypharmacy was defined as proportion of patients who were prescribed >= 5 drugs with different ATC4 codes in a month or in each quarter of the year. Results: Turkey's total population is 82 million; 7,186,204 are aged 65 and over, constituting 8.8% of the total. Of this geriatric population, 6,104,798 (85.0%) had at least one prescription in 2018. Each geriatric patient had 6.4 prescriptions, with each prescription containing an average of 2.9 drugs with different fourth-level Anatomical Therapeutic Chemical codes. Each drug was prescribed in 2.7 boxes on average. Of these prescribed patients, 14.3% received prescriptions containing >= 5 drugs four or more times during 2018. The percentage of patients who received at least one prescription per month containing >= 5 drugs ranged between 16.4% and 20.7%. The most commonly prescribed drugs were acetylsalicylic acid, diclofenac, paracetamol, and pantoprazole. Conclusion: Polypharmacy is a critical health problem among geriatric population in Turkey as in other industrialized countries. Educating physicians as well as the public is essential to overcome polypharmacy.