Browsing by Author "Kus, Canan"

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    Benzamide and Benzamidine Compounds as New Inhibitors of Urokinase-type Plasminogen Activators
    (2018) Kus, Canan; Ozer, Ezgi; Korkmaz, Yesim; Yurtcu, Erkan; Dagalp, Rukiye; 0000-0001-6141-6788; 0000-0003-4930-8164; 0000-0002-7335-8578; 30112993; AAG-1459-2020; AAA-2998-2021; W-1812-2017
    Background & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b] pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05). Conclusion: uPAR levels obtaining from 4b and 7d administration were similar to 5-FU for both cell lines colorectal (Colo205, CCL-222) and hepatocellular (HepG2, CCL-23) carcinoma cells (p<0.05).