Browsing by Author "Kucukoduk, Ali"

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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model
(2019) Kucukoduk, Ali; Helvacıoglu, Fatma; Haberal, Nihan; Dagdeviren, Atilla; Bacanli, Didem; Yilmaz, Gursel; Akkoyun, Imren; 0000-0001-8990-8282; 30851776; P-2877-2014
Objective: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR). Design: C57BL/6J mouse model. Methods: Two negative control groups (n = 6 each; one of which received IV sterile dimethyl sulfoxide [DMSO]) of C57BL/6J-type mice were exposed to room air. The HIR groups included 36 C57BL/6J-type mice exposed to 75% +/- 2% oxygen from postnatal day (PD) 7 to PD 12. On PD 12, these mice were randomized into 6 groups (n = 6 each): 2 HIR control groups (one of which received IV-DMSO), 2 IV-AST groups (10 and 100 mu g/mL), and 2 IP-AST groups (0.5 and 5 mg/kg). We measured ND by counting neovascular tufts in cross sections and examined histological, ultrastructural changes via light and electron microscopy. Apoptosis was detected using terminal deoxynucleotidyl transferase-mediated nick end-labeling. Results: No ND was detected in the negative control groups. ND levels were not significantly different between high- and low-dose AST for either means of administration. However, ND levels were significantly lower in the AST groups, regardless of delivery, compared to the control groups. The means of delivery (IP versus IV) also yielded significant differences in ND. The incidence of mitochondrial dysmorphology and apoptosis were lower in groups receiving AST. Conclusions: AST seems to suppress ND and has anti-apoptotic activity in the HIR mouse model.
Atypical Herpetic Corneal Endothelitis:: A Case Report
(2016) Karalezli, Aylin; Kucukoduk, Ali; Bozkurt, Banu
Corneal endotheliitis; frequently caused by viruses, is a disorder in which corneal endothelium is the primary site of the inflammation. We discuss a case of atypical herpetic endotheliitis presented with unilateral diffuse corneal edema with no signs of anterior chamber reaction.
Comparison of refractive outcomes using Scheimpflug Holladay equivalent keratometry or IOLMaster 700 keratometry for IOL power calculation
(2021) Aksoy, Mustafa; Asena, Leyla; Gungor, Sirel Gur; Kucukoduk, Ali; Akman, Ahmet; 0000-0001-8024-4758; 33733281
Purpose This study aims to compare postoperative refractive error results using Pentacam (Oculus Optikgerate GmbH) Holladay equivalent keratometry readings (EKR) or IOLMaster 700 (Carl Zeiss Meditec AG) keratometry (K) values in IOL power calculation. Material and methods This retrospective study included 54 eyes of 31 patients who underwent cataract surgery. Preoperative biometric measurements of all patients were obtained using IOLMaster 700 followed by Pentacam measurements. IOLMaster 700 K measurements on horizontal (K1) and vertical (K2) axes and EKR measurements on 2 mm (EKR2mm), 3 mm (EKR3mm) and 4.5 mm (EKR4.5 mm) corneal zones were recorded. EKR4.5 mm value and IOLMaster 700 K values were used in Holladay-II, SRK/T, Haigis, and Hoffer-Q formulas to calculate predictive refractive error (PRE). Absolute refractive error (ARE) was calculated as the absolute difference between actual postoperative refractive error (APRE) and PRE values. Results Mean age was 72.2 +/- 8.3 (51-87) years and mean IOL power was 21.5 +/- 2.9 D (18-23 D). There was no significant difference between PRE values when IOLMaster 700 K measurements and EKR4.5 mm K measurements were used in Holladay-II, SRK/T, Haigis, and Hoffer-Q formulas (p = 0.571, p = 0.833, p = 0.165, p = 0.347, respectively). There was no significant difference between APRE and ARE values (p = 0.124). According to mean ARE results, the closest estimate was achieved when the IOLMaster 700 K values were used in the Holladay-II formula (p = 0.271). Conclusion IOLMaster 700 K measurement and Pentacam EKR4.5 mm measurements can be used interchangeably. IOLMaster 700 K values yielded the most predictive measurement of the refractive result using the Holladay-II formula.
Non-Contact and Contact Tonometry in Corneal Edema
(2016) Gungor, Sirel Gur; Akman, Ahmet; Kucukoduk, Ali; Asena, Leyla; Simsek, Cem; Yazici, Ayse Canan; https://orcid.org/0000-0001-6178-8362; https://orcid.org/0000-0001-8024-4758; https://orcid.org/0000-0002-6848-203X; https://orcid.org/0000-0001-8003-745X; https://orcid.org/0000-0002-3132-242X; 26583789; AAD-5967-2021; E-5914-2016; N-8970-2018; AAS-6810-2021
Purpose To compare the intraocular pressure (IOP) values by Goldmann applanation tonometry (GAT) and Reichert 7 CR noncontact tonometry (R7CR-NCT) in patients with postsurgical corneal edema and to examine the impact of postoperative corneal edema on these values. Methods Forty-six patients with grade 4 and 5 cataracts were included in this study. Intraocular pressure was measured using GAT and R7CR-NCT before and 1 day after phacoemulsification. Central corneal thickness (CCT) was determined before and after surgery to quantify postsurgical corneal edema. The R7CR-NCT provided a Goldmann-correlated IOP (IOPg) and corneal-compensated IOP (IOPcc). Results The CCT increased significantly 1 day after surgery (the mean preoperative CCT, 543.5 25.4 m; the mean postoperative CCT, 681.5 +/- 19.8 m; p < 0.001), a mean increase of 26.7%. The preoperative R7CR-NCT measurements (the mean IOPcc, 18.8 +/- 5.6 mm Hg; the mean IOPg, 17.8 +/- 4.5 mm Hg) were significantly higher than GAT measurements (the mean GAT-IOP, 16.0 +/- 3.4 mm Hg) (p < 0.001). On postoperative day 1, the R7CR-NCT measurement (the mean IOPcc, 27.0 +/- 9.8 mm Hg; the mean IOPg, 25.1 +/- 8.9 mm Hg) were significantly higher than GAT measurements (the mean GAT-IOP, 18.3 +/- 7.9 mm Hg) (p < 0.001). The difference between postoperative R7CR-NCT and GAT-IOP values were significantly higher than the difference between preoperative R7CR-NCT and GAT-IOP values (p < 0.001 for both IOPcc to GAT-IOP and IOPg to GAT-IOP). The difference between postoperative IOPcc and GAT-IOP was significantly correlated to the change in CCT (r = 0.526, p < 0.001). Similarly, the difference between postoperative IOPg and GAT-IOP was significantly correlated to the change in CCT (r = 0.536, p < 0.001). Conclusions The R7CR-NCT IOP values were high in patients with postsurgical intensive corneal edema. Consequently, the difference between R7CR-NCT IOP and GAT-IOP increased in edematous corneas.
Retinal Nerve Fiber Layer Thicknesses in Three Different Optic Nerve Head Size Groups Measured by Cirrus Spectral Domain Optical Coherence Tomography
(2016) Gungor, Sirel Gur; Akman, Ahmet; Kucukoduk, Ali; Colak, Meric; 27800261
Objectives: To compare the retinal nerve fiber layer (RNFL) thicknesses in three different optic nerve head (ONH) size groups measured by Cirrus spectral domain optical coherence tomography (OCT). Materials and Methods: Between January and March 2013, 253 eyes of 253 healthy subjects were enrolled in this study (mean age: 42.7 perpendicular to 7.4 years [28-62 years]; 121 men and 132 women). The patients were divided into 3 groups according to ONH size: 77 patients in the "small ONH" group (ONH area < 1.63 mm(2)), 90 patients in the " medium ONH" group (ONH area 1.63-1.97 mm(2)), and 86 patients in the "large ONH" group (ONH area > 1.97 mm(2)). Results: There were significant differences in superior (p=0.008), inferior (p=0.004) and average RNFL thickness (p=0.001) between the small, medium and large ONH groups. Positive correlations between ONH size and inferior/ average RNFL thicknesses were significant but very weak (r=0.150, p=0.017 and r=0.157, p=0.013 respectively). Conclusion: RNFL thickness as measured by Cirrus OCT is positively correlated with ONH size and the differences in RNFL thickness were statistically significant between groups. This correlation and difference may be the result of a varying distance between the circular scan and the ONH margin.