Browsing by Author "Koseoglu, Hikmet"

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A Case of Eccrine Porocarcinoma Accompanying Renal Cell Carcinoma
(2021) Mansur, Ayse Tulin; Karsiyakali, Nejdet; Demirci, Gulsen Tukenmez; Koseoglu, Hikmet; Akman, Yavuz; Yildiz, Semsi; 0000-0002-0416-9167; 0000-0002-0709-0331
In this case report, we present the coexistence of eccrine porocarcinoma (EPC) and renal cell carcinoma (RCC) in a 69-year-old male patient whose surgical resection pathology of the skin lesion in the right gluteal region was reported as EPC and concurrent radical nephrectomy pathology of the right renal mass was reported as RCC
A Case of Paratesticular Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma
(2015) Koseoglu, Hikmet; Yorukoglu, Kutsal
A very rare case of paratesticular atypical lipomatous tumor/a case of well-differentiated liposarcoma diagnosed in an elderly patient is presented together with macroscopic surgical photographs and photographs of microscopic pathological sections.
Exosomal IncRNA-p21 levels may help to distinguish prostate cancer from benign disease
(2015) Isin, Mustafa; Uysaler, Ege; Ozgur, Emre; Koseoglu, Hikmet; Sanli, Oner; Yucel, Omer B.; Gezer, Ugur; Dalay, Nejat; 25999983
Exosomes are membranous vesicles containing various biomolecules including IncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 IncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of IncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.
Monopolar and Bipolar Modalities of Transurethral Prostate Resection
(2015) Koseoglu, Hikmet; Akman, Ramazan Yavuz
Benign prostate hyperplasia (BPH) related lower urinary tract symptoms (LUTS) is among the most common diseases in the aging male. Both medical and surgical treatment modalities have been improved strikingly in the last 20 years. Transurethral resection of the prostate (TUR-P) is still the gold standard for the surgical treatment for the prostates with the volume of 30-80 ml. Today, besides monopolar classical TUR-P systems which are still widely used, bipolar TUR-P systems are also being used in the increasing numbers. Results of recent meta-analyses did not determine difference between monopolar and bipolar systems in terms of clinical efficacy, in addition, showed bipolar advantages in terms of bleeding and clot retention. Both monopolar and bipolar systems shall better be used until the results of multi-centered prospective studies which compare both modalities with high number of patients together with controlling surgeon factors.
No Tumor Suppressor Role for LKB1 in Prostate Cancer
(2021) Koseoglu, Hikmet; Celebi, Asuman; Galamiyeva, Gunay; Dalay, Nejat; Ozkardes, Hakan; Buyru, Nur; 34370601
To elucidate the pathogenesis of prostate diseases, following in silico analysis, the LKB1 gene was selected for further investigation. The LKB1 gene has been associated with poor prognosis and is frequently mutated in different types of cancers. In this study, 50 benign prostatic hyperplasia (BPH) and 57 prostate cancer (PCa) tissues, including matched normal tissue for the patients, were analyzed by qRT-PCR and DNA sequencing for LKB1 expression and the mutation profile, respectively. Expression of LKB1 was increased in 60.7% of the PCa tissues compared with noncancerous tissue samples (p <= 0.001). However, LKB1 expression was lower when compared with normal tissues in BPH (p = 0.920). Four coding sequence alterations were detected in BPH. Three silent mutations were located in codons 9, 32, and 275 and a missense mutation was observed in codon 384. Six alterations were identified in the intronic regions of the LKB1 gene in both PCa and BPH. Five mutations were observed in both patient groups. A new alteration in intron 6 was observed in a patient with PCa. The LKB1 gene may be associated with benign transformations rather than the tumors in prostate pathogenesis when its expression and mutation status are considered. However, the mechanism of LKB1 in PCa needs further studies.
Prostate Biopsy in the Elderly: Histologic Findings and Treatment Necessity
(2014) Akman, Ramazan Yavuz; Koseoglu, Hikmet; Oguzulgen, Ahmet Ibrahim; Sen, Erhan; Yaycioglu, Ozgur; 25374232
The aim of this study is to determine results of high prostate specific antigen (PSA) or abnormal digital rectal examination driven prostate biopsies performed in our Department in men aged 75 or more and to show the characteristics of pathology results. The hospital records of the patients who had high PSA or abnormal digital rectal examination driven prostate biopsy in two common university based research hospitals have been reviewed retrospectively. Patients aged 75 years or older at the date of biopsy whose records provided pathology results and full medical history were evaluated for the study. A total of 103 patients were evaluated with a mean age of 79.4 +/- 3.4 years. More than half of the patients (55.1%) were in their seventh decade and the rest were in the eighth decade. Median PSA value was 15.0 (range 2.1-4500) ng/ml. In most of the biopsies (67%), PSA levels were lower than 20 ng/ml. In almost half of the patients (48%), digital rectal examination was abnormal. In 68.9% of the patients, there were at least one or more associated co-morbid diseases. Gleason scores were 7 or higher in 73%, and 8 or higher in 37% of the patients with prostate cancer. Four of the 70 (6%) patients had bone metastases. Castrations were applied to most of the patients with prostate adenocarcinoma (% 79). High percentage of high grade (Gleason 7 or more) prostate adenocarcinoma in the elderly refutes the perception of prostate cancer in this age group as clinically insignificant. Therefore, it is to be kept in mind that prostate cancer in the elderly an be clinically significant and prostate biopsies are to be performed when necessary.