Browsing by Author "Koksal, B. T."

Now showing 1 - 3 of 3

Serum Angiopoietin-1, Angiopoietin-2 and Periostin Levels in Children with Recurrent Bronchiolitis
(2018) Koksal, B. T.; Aydin, Ozdemir B.; Tekindal, M. A.; Ozbek, Yilmaz O.; https://orcid.org/0000-0001-9580-7656; AAF-2109-2021
Serum Vitamin D Levels Decrease in Children with Acute Urticaria
(2016) Ozdemir, B.; Koksal, B. T.; Karakas, N. M.; Ozbek, O. Y.; 0000-0003-2974-9579; 0000-0003-4286-7086; 0000-0001-9580-7656; 27475773; HKW-0623-2023; AAJ-2034-2021; AAX-3831-2020; AAF-2109-2021
Background: Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders. Objective: The aim of this study was to evaluate serum vitamin D levels in acute urticaria. Methods: We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group. Results: There were no significant differences in baseline variables (age, gender, weight) between the groups. Vitamin D deficiency (<20 ng/ml) was significantly higher in patients with acute urticaria than in control patients. Serum 25(OH)D levels were significantly lower in the study group compared to those in the control group (13.1 +/- 4.3 vs 28.2 +/- 7.4 ng/mL, p<0.05). Moreover, we found negative correlation between mean duration of acute urticaria and serum vitamin D levels (p<0.01). Conclusion: This study revealed a significant association of lower serum 25(OH)D concentrations with acute urticaria and an inverse relationship with disease duration. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of acute urticaria and a predictive marker for disease activity in acute urticaria. A potential role of vitamin D in pathogenesis and additive therapy in acute urticaria needs to be examined. (C) 2016 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
Single and Multiple Food Allergies in Infants with Proctocolitis
(2018) Koksal, B. T.; Baris, Z.; Ozcay, F.; Ozbek, O. Yilmaz; 0000-0002-5214-516X; 0000-0001-9580-7656; 28739021; ABG-5684-2020; AAB-4153-2020; AAF-2109-2021
Background: Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined. Objective: This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies. Methods: A total of 132 infants with proctocolitis were evaluated retrospectively. All of the infants were diagnosed by a paediatric allergist and/or a paediatric gastroenterologist according to guidelines. Clinical features of the infants, as well as results of a complete blood count, skin prick test, specific immunoglobulin E, and stool examinations or colonoscopy were recorded. Results: Cow's milk (97.7%) was the most common allergen, followed by egg (22%). Forty-five (34.1%) infants had allergies to more than one food. Infants with multiple food allergies had a higher eosinophil count (613 +/- 631.2 vs. 375 +/- 291.9) and a higher frequency of positive specific IgE and/or positive skin prick test results than that of patients with a single food allergy. Most of the patients whose symptoms persisted after two years of age had multiple food allergies. Conclusions: There is no difference in clinical presentations between infants with single and multiple food allergies. However, infants with multiple food allergies have a high blood total eosinophil count and are more likely to have a positive skin prick test and/or positive specific IgE results. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.