Browsing by Author "Kocyigit, Hikmet"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Effect of platelet-rich plasma on serum and urine biomarkers in patients with knee osteoarthritis
    (2020) Kuculmez, Ozlem; Sirin, Fevziye Burcu; Sarikaya, Nese Olmez; Kocyigit, Hikmet; 0000-0002-8900-0060; AAM-4037-2021
    Background: Biomarkers may reflect changes in cartilage metabolism and could be used in diagnosis and evaluation of treatment response in knee osteoarthritis. The aim of this study is to determine the effect of platelet rich plasma (PRP) injections on serum and urine biomarkers in patients with knee osteoarthritis (OA). Methods: The study included 26 patients who were diagnosed as grade III knee OA according to ACR criteria and Kellgren-Lawrence classification. One cc of PRP was obtained from 20 cc of venous blood after double centrifugations at 400 g for 10 minutes. The patients received 3 injections of PRP at 3-weeks intervals. Serum Procollagen II N-terminal propeptide (PIINP), osteocalcin (OC), cartilage oligomeric matrix protein (COMP) and urine collagen-II telopeptide (U-CTX-II) were examined in all patients before treatment and at 3 and 6 months. Clinical outcome was evaluated using Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire, SF-36 and visual analog scale (VAS) in all patients before injection and at 3 and 6 months follow-up visits. Results: There was no statistically significant difference in cartilage Type II collagen (CII) degradation markers (CTX-II, COMP) and biosynthesis marker of PIINP (P>0.05). Significant increase was determined in serum OC levels (P<0.05) which reflects CII biosynthesis. Statistically significant improvement in all WOMAC parameters (P<0.05) and subscores of SF-36 (P<0.05) was noted. Conclusion: We found significant clinical improvements in knee OA patients treated with PRP injections. Our results suggest that PRP injection does not affect cartilage breakdown but effects CII biosynthesis, which is reflected by increased OC levels. However further studies are needed.
  • No Thumbnail Available
    Item
    Efficacy of Ultrasound Guided Platelet-Rich Plasma in The Repair of Partial and Full-Thickness Supraspinatus Tears
    (2019) Akan, Ozlem; Mete, Berna Dirim; Kocyigit, Hikmet; Bayram, Korhan Baris; Yilmaz, Huriye Erbak; Tosun, Aliye; https://orcid.org/0000-0002-5054-5784; HLG-9611-2023
    Background: Rotator cuff tears [RCT] are one of most common shoulder pain causes. Some patients do not give response to conservative treatments and patients couldn't get sufficient recovery after the surgery. Ultrasound guided platelet-rich plasma [PRP] administration may decreases the RCT sourced pains and improves functional abilities in patients with partial and complete rotator cuff tear. In this control group included study, the effectiveness of PRP treatment on RCT's has been revealed. Methods: In this randomized controlled clinical trial, the study included 90 patients who were randomized to four groups as: partial tear PRP, partial tear control, complete tear PRP and complete tear control. One cc PRP was obtained from 20 cc blood samples of patient, after double centrifuged at 400 g for 10 minutes. Under musculoskeletal ultrasound guidance, the PRP groups were given 3 injections of PRP in the affected shoulder at 3-week intervals. All groups were given a home exercise program 3 times per week. The range of motion, Quick DASH, Shoulder Pain and Disability Index [SPADI], Constant and VAS scores were used for the evaluation of patients at 3, 6 and 9 weeks, and 3, 6 and 12 months for follow-up visits. Results: In all groups, statistically significant improvements were observed in ROM, Quick DASH, SPADI, Constant and VAS scores [P < 0.05] at 12 months. Compared to control groups, more prominent improvements in all these clinical parameters were seen in PRP groups [P < 0.001]. It was also observed that the improvements seen after their first injection in PRP patients had persisted at 12 months. There was no significant difference in their improvements in these clinical parameters between PRP injected patients with partial RC tear and PRP injected patients with complete RC tear. Conclusion: We found significant and sustained improvement in pain and functional outcomes in PRP treated patients with RC tear. Our results suggest that PRP is the powerful treatment option in both patients with partial and complete RC tear and it may be an alternative approach before surgery in patients that do not benefit from conservative treatments.