Browsing by Author "Kiziltan, Erhan"

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An Alternative Low-Cost Solution for Tracking Laboratory Animals
(2020) Kiziltan, Erhan; Aydin, Leyla; 0000-0001-6029-3835; AAD-6090-2021
Objectives: Monitoring animal behavior under various conditions can provide important information on their neuropsychological status, including learning, memory, and cognitive activity. Several commercial tracking systems are available, but they may be too expensive for low-budget projects. This study developed an alternative solution for automated animal tracking in behavioral experiments. Methods: The proposed system was designed to analyze a set of images sampled from a recorded video file in chronological order. The instantaneous location of the animal in each image frame was defined automatically, using a feature-extraction algorithm. Distances traveled were calculated using the coordinates of the successive instantaneous locations. The algorithm was tested using two arenas: the Morris water maze and open field test. The calculated measures were compared with those obtained manually. The internal consistency of the dataset was checked using Cronbach's alpha. The accuracy of the results was evaluated using the paired samples t-test and Pearson correlation, with the level of statistical significance set at p<0.01. Results: A statistical comparison of the distances traveled, which were derived from the coordinates of successive locations, did not differ significantly between the manual and automatic methods (r=0.954 and p=0.792 for the Morris water maze; r=0.996 and p=0.024 for the open field test). Conclusions: These results suggest that the algorithm is reliable and valid for estimating coordinates and may serve as a high-resolution tool for animal behavior experiments. We intend to make this software freely available to interested readers and to open feedback channels for further development.
Cognitive Deterioration Following Strength Training in Adolescents
(2019) Yargic, MP; Aydin, Leyla; Erdagi, Kenan; Kiziltan, Erhan; https://orcid.org/0000-0001-6029-3835; AAD-6090-2021
Detection of Visual-Auditory Reaction Rates in Individuals with Type 2 Diabetes Mellitus
(2023) Bilaloglu, Melisa; Ergun, Ahmet; Altay, Feride P.; Iyidir, Ozlem T.; Kiziltan, Erhan; 0000-0002-9994-9405; 0000-0001-6029-3835; 0000-0001-5305-6807; AAL-7975-2021; AAD-6090-2021; K-7904-2019
AIM:The primary purpose of our study was to understand the damage in the peripheral nerves of patients with diabetes and to determine the change in patients' reaction rates and perceptions by the age groups, duration of diabetes, fasting plasma glucose and HbA1c values, and compare these with those of the healthy individuals. METHODS: This study was carried out at the Baskent University Hospital Endocrinology and Metabolic Diseases Outpatient Clinic. A total of 64 patients diagnosed with type 2 diabetes and 64 healthy controls were included in the study. Finger tapping, visual, and auditory reaction time tests were performed on the subjects, respectively. The subjects' fasting plasma glucose and HbA1c levels, and the duration of their diabetes were recorded. Analyses were per -formed using the SPSS version 25. Differences were considered statistically significant when the p-value is <0.05. RESULTS: It was observed that the participants in the control group between the ages of 18-34 showed a faster reaction in all tests (p=0.01), but the difference in reaction rates in both groups decreased as the age increased. There were positive cor-relations between the duration of type 2 diabetes and the visual and auditory examination results (r= 0.69, p<0.05, r=0.52, p<0.05, respectively). There was also a positive correlation between the HbA1c (%) and the visual (r=0.97, p<0.05) examina-tion results. CONCLUSIONS: As the patients' HbA1c levels and the time spent with type 2 diabetes increased, their reaction rate and per-ception skills decreased. Especially in the early stages of the disease, cognitive decline was observed to be rapid. It is thought that diabetic control is significant.
Determination of Audio-Visual Reaction Times in Individuals with Type 2 Diabetes Mellitus
(2022) Bilaloglu, Melisa; Altay, Feride Pinar; Gul, Eylem; Ergun, Ahmet; Kiziltan, Erhan
Development, Validity, and Reliability of the Auditory and Speech Performance Test for Children
(CANADIAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY AND AUDIOLOGY, 2024-05-02) Hancer, Hale; Kiziltan, Erhan; Tan, Pinar Civak; Gokmen, Dery; Hayme, Serhat; Yilmaz, Suna Tokgoz
Auditory processing and speech processing disorders negatively affect school -aged children. To minimize these negative effects, individuals in the risk group should benefit from the positive contribution of early intervention with a comprehensive evaluation. The aim of this study was to develop the Auditory and Speech Performance Test for Children and analyze its validity and reliability. In the development of the Auditory and Speech Performance Test for Children, discrimination and recognition subtasks were built for both auditory and speech performance. Meaningful and meaningless minimal pairs were used in the subtasks. A silent background was used for auditory performance, and noise stimuli were combined into minimal pairs for speech performance. Audiovisual materials were integrated into the finger-tapping test. The Auditory and Speech Performance Test for Children was administered to 307 children with typical development and to 80 children with specific learning disabilities. The Auditory and Speech Performance Test for Children calculated children's reaction times for pressing speed and accuracy of pressing the correct key. The data were analyzed for content, construct validity, internal consistency, and test -retest reliability. The content validity index value was found to be high (.89-1.0). The Auditory and Speech Performance Test for Children was explained as a two -factor model using exploratory factor analysis (eigenvalue = 1.92, total variance = 66.65%). It was found to be discriminative according to age, groups, subtests, and 27% bottom and top scores (all were significant atp < .001). Internal consistency (.77-.90) and test -retest values (.89-.93) of the Auditory and Speech Performance Test for Children in the total test scores were calculated within reliable values. In conclusion, we developed a valid and reliable screening tool for auditory and speech performance in children.
Distribution of Dynamic Forces on Patient Specific Vascular Model:Application of computational Hemodynamics
(2015) Kiziltan, Erhan
Objective: Recent advances in computerized image processing made the early diagnosis and elective invasive treatment of vascular pathologies possible. However, studies state that the complication rates of elective procedures are higher thatn that the of untreated cases. And, making the decision between protection from life threatening complications and unnecessary interventions is a controversial issue. Therefore, recent studies put emphasis on multidisciplinary motivation,; consequently "computational fluid dynamics" took place in medical simulations. With the aim of setting up hemodynamic forces were discussed in vascular models. Methods: Three dimensional distribution of hmodynamic forces in aneurisam and stenotic models were computed by uisng two different patient specific simulations which were constructed on two different vessel models of "parametric" and "realistic" approaches. Results: The results were consistent with almost all common practical knowledge. Continuity and Bernoulli's laws imply that a fluid moving through a wide vessel must move more quickly when the vessel narrows and the pressure decreases gradually. The relation between vessel geometry and velocity vectors in maintained laminor flow conditions was demonstrated. The impacts of radial forces and vessel wall structure on spatial distribution of the displacement in vessel geometry were also shown. Additionally spatial distribution of the axial force of "wall shear stress" which was recently suggested to be a hightly reliable measure was evaluated. Conclusion: Patient specific simulations that are belived to be the core of the future project of "clinical diagnostic expert systems" will be an important tool; in prescribing patient specific treatment and in the assessment of complications risks.
Do You Model Yourself: Solid Organ Modelling Using Three-dimensional Printing Technology
(2017) Tuleylioglu, Hamit Bora; Kasgoz, Inci Zuhal; Kayikcioglu, Ayca; Seferoglu, Ege; Celik, Taha Ersin; Kiziltan, Erhan; 0000-0001-6029-3835; AAD-6090-2021
Effects of Cognitive Load and State of Vigilance on Sympathetic Skin Response
(2022) Karimi, Nazli; Dolu, Nazan; Kiziltan, Erhan; Sirinoglu, Tugce; Gundogan, Nimet Unay
Evaluating the Effects of Different Cognitive Tasks on Sympathetic Responses: Implementation of a High-Precision, Low-Cost Complementary Method
(2023) Karimi, Nazli; Ozgur, Sezgi Firat; Kiziltan, Erhan
The Impacts of Central Fatigue on the Polyphasic Nature of Tapping Performance
(2018) Kiziltan, Erhan; Aydin, Leyla; Ogus, Ersin; Azizagaoglu, Bahadir; Buyukkaraman, Arda; Doga, Selen; Ertuk, Gizem; Kus, Cansel; 0000-0002-9877-421X; 0000-0001-6029-3835; AAJ-1058-2021; ABC-5392-2020; AAD-6090-2021
Objective: As a non-specific symptom muscle fatigue mostly accompanies neuromuscular diseases and also occurs frequently in healthy individuals. Fatigue phenomenon is considered to be multidimensional symptom. There have been still discussions on the origin whether it depends primarily on the intrinsic properties of muscle itself (peripheral mechanisms) or the nervous system that controls muscle (central mechanisms). This study aimed to investigate the effects of central fatigue on the performance of maximal voluntary repetitive movement and discusses the specificity of finger tapping task test as a simple diagnostic tool for fatigue. Methods: For this purpose, 27 healthy, male, right-handed volunteer performed the 20-s of finger tapping task test for four times. The one was for control and the other three were performed right after induction of three different central fatigue models. Temporal behavior of tapping performances were evaluated based on inter-tap intervals and the statistical comparison were made by regression analysis. Results: The results showed that the partial evaluation of the task in time domain instead of complete test period yielded with statistically significant differences between control and fatigue models (p<0.001) and even in between the fatigue models. Conclusion: Approximately the first 5-s of a finger tapping task consists of both motor learning processes and dynamics of energy consumption from anaerobic sources. However, it reflects dominantly the central components of fatigue. We may conclude that the temporal behavior of tapping performance following the induction of specific fatigue model may help making further discrimination for the origin of fatigue.
Internal Motivation Modulates Voluntary Repetitive Movements: "Ha gayret" Energy
(2017) Kiziltan, Erhan; Aydin, Leyla; Zengin, H. Yagmur; 0000-0001-6029-3835; 0000-0002-9855-2449; AAD-6090-2021; ABC-5392-2020; ABA-3224-2021
Is Central Origin of Muscle Fatigue Distinguished Solely in Finger Tapping Performance?
(2017) Aydin, Leyla; Buyukkaraman, Arda; Kiziltan, Erhan; Dogan, Selen; Ogus, Ersin; Erturk, Gizem; Azizagaoglu, Bahadir; Kus, Cansel; 0000-0001-6029-3835; 0000-0002-9877-421X; ABC-5392-2020; AAD-6090-2021; AAJ-1058-2021
As a non-specific symptom muscle fatigue mostly accompanies neuromuscular diseases and also occurs frequently in healthy individuals. Fatigue phenomenon is considered to be multidimensional symptom. There have been still discussions on the origin whether it depends primarily on the intrinsic properties of muscle itself (peripheral) or the nervous system that controls muscle (central). This study aimed to investigate the effects of central fatigue on finger tapping performance and discusses the specificity of finger tapping task test as a simple diagnostic tool for fatigue. For this purpose, 27 healthy, male, right-handed volunteer performed four 20-s of finger tapping task tests. The one was for control and the other three were followed by three different central fatigue models. Temporal behavior of tapping performances were evaluated based on inter-tap intervals and the statistical comparison were made by regression analysis. The results showed that the partial evaluation of the task instead of complete test period yielded with statistically significant differences between control and fatigue models (p<0.001) and even in between fatigue models. Approximately the first 5-s of a finger tapping task consists of motor learning processes and dynamics of energy consumption from anaerobic sources therefore, reflects the central components of fatigue, dominantly. We may conclude that the temporal behavior of tapping performance following the induction of specific fatigue model may help making further discrimination for the origin of fatigue.
Laboratory Animal Tracking in Behavioral Experiments: An Alternative Low Cost Solution
(2016) Kiziltan, Erhan; Aydin, Leyla; 0000-0001-6029-3835; AAD-6090-2021; ABC-5392-2020
Polyphasic Temporal Behavior of Finger-Tapping Performance: A Measure of Motor Skills and Fatigue
(2016) Aydin, Leyla; Kiziltan, Erhan; Gundogan, Nimet Unay; https://orcid.org/0000-0001-6029-3835; https://orcid.org/0000-0001-7784-9641; 25988674; ABC-5392-2020; AAD-6090-2021; AAK-4338-2021
Successive voluntary motor movement involves a number of physiological mechanisms and may reflect motor skill development and neuromuscular fatigue. In this study, the temporal behavior of finger tapping was investigated in relation to motor skills and fatigue by using a long-term computer-based test. The finger-tapping performances of 29 healthy male volunteers were analyzed using linear and nonlinear regression models established for inter-tapping interval. The results suggest that finger-tapping performance exhibits a polyphasic nature, and has several characteristic time points, which may be directly related to muscle dynamics and energy consumption. In conclusion, we believe that future studies evaluating the polyphasic nature of the maximal voluntary movement will lead to the definition of objective scales that can be used in the follow up of some neuromuscular diseases, as well as, the determination of motor skills, individual ability, and peripheral fatigue through the use of a low cost, easy-to-use computer-based finger-tapping test.
The Role of Finger Tapping Task in the Assessment of Central Fatigue
(2016) Aydin, Leyla; Kiziltan, Erhan; Ogus, Ersin; Azizagaoglu, Bahadir; Buyukkaraman, Arda; Dogan, Selen; Erturk, Gizem; Kus, Cansel; 0000-0002-9877-421X; 0000-0001-6029-3835; ABC-5392-2020; AAJ-1058-2021; AAD-6090-2021
The Use of Computer Based Test Battery for The Assessment of Cognitive Functions in Elite-Level Strength Training
(2019) Yargic, Melda Pelin; Erdagi, Kenan; Aydin, Leyla; Kiziltan, Erhan; https://orcid.org/0000-0001-6029-3835; AAD-6090-2021
The aim of this study was to propose a standard test battery consisting of necessary tools for measuring and comparing the various aspects of cognitive outcomes. The battery was used to determine whether adolescent women performing regular elite-level strength training differed from their sedentary peers in terms of cognition, and also to determine how a single session of strength training affects cognition in highly trained adolescents. Motor functions, ability of sustaining attention and executive functions of 25 elite female weightlifters and 22 sedentary females were evaluated through finger tapping performance, visual reaction time (VRT) and recognition visual reaction time (R-VRT) data. Weightlifters were tested before and after a training session, sedentary controls were tested only during resting. There was a significant increase in mean complex R-VRT of weightlifters after training (p<0.01). In R-VRT tests, rate of false answers increased significantly after training (p<0.05). Mean VRT of weightlifters (during rest) and sedentary peers were not different in any of the tests (p>0.05). Total number of taps and mean inter-tap intervals did not show any difference in the weightlifter group before and after training, also between weightlifters and sedentary controls (p>0.05). Elite level strength training does not improve cognition in adolescence. Adolescent weightlifters' executive functions are deteriorated following a single training session however, this effect is temporary.