Browsing by Author "Keskin, Goksal"

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INTERLEUKIN-27 IN TAKAYASU'S ARTERITIS: SERUM LEVELS AND RELATIONSHIP WITH DISEASE ACTIVITY
(2019) Keskin, Goksal; Inal, Ali; Cerci, Pamir; Olmez, Umit
Investigating the Role of IL-33 in the Pathogenesis of Behcet's Disease
(2017) Cerci, Pamir; Altiner, Seda; Inal, Ali; Kose, Kenan; Keskin, Goksal; Olmez, Umit; 0000-0002-0690-2529; 28412856; J-8056-2012
Objectives: Behcet's disease (BD) is an inflammatory disease, characterized by oral aphthous lesions, recurrent uveitis, skin lesions, and genital ulcerations. Increased release of several cytokines may play a role in the inflammatory stages of BD. IL-33, a member of the IL-1 cytokine superfamily, plays an important role in inflammation. We analyzed serum IL-33 concentration in BD patients to assess its possible role in the pathophysiology of this disease. Methods: The study included 54 BD patients, 31 with active BD and 23 with inactive BD as well as 18 matched healthy controls. Serum IL-33 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results: The mean serum IL-33 levels were 4.84 +/- 2.81 pg/ml in the BD patients (6.16 +/- 2.94 pg/ml in the active stage and 2.86 +/- 0.54 pg/ml in the inactive stage) and 2.88 +/- 0.42 pg/ml in the healthy controls. Serum IL-33 levels were significantly higher in patients with BD compared with the healthy controls (p < 0.01). In active Behcet patients with arthritis the mean serum IL-33 level was higher but this finding was not statistically significant (p = 0.122). Conclusion: IL-33 may play a significant role of in the pathogenesis of BD.
Investigating the Role of IL-33 in the Pathogenesis of Familial Mediterranean Fever
(2016) Keskin, Goksal; Tutluer, Seda; Inal, Ali; Cerci, Pamir; Olmez, Umit; 0000-0002-0690-2529; J-8056-2012
The relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitis
(2019) Kultur, Turgut; Oztas, Dilek; Keskin, Dilek; Keskin, Goksal; Inal, Ali; Kara, Halil; 31893276
Objectives: The aim of this study was to investigate the relationship between serum vitamin D receptor (SVDR) levels and disease activity parameters in patients with ankylosing spondylitis (AS). Patients and methods: Between July 2016 and January 2017, a total of 62 patients (51 males, 11 females; mean age 36.5 +/- 12.8 years; range, 23 to 49 years) with AS and 32 healthy volunteers (25 males, 7 females; mean age 41.57 +/- 13.6 years; range, 26 to 48 years) were included in the study. The SVDR levels were measured using the enzyme-linked immunosorbent assay. Erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) levels were recorded. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were used to assess disease activity. Results: Although there was no significant difference between the patient and control groups (p=0.66), SVDR levels were significantly elevated in patients with active AS (BASDAI score >= 4) (p=0.01). The SVDR levels significantly increased in AS patients with peripheral joint involvement and enthesitis (p=0.01, p=0.05, respectively). The SVDR levels significantly elevated in patients treated with non-steroidal anti-inflammatory drugs, compared to those treated with biological agents and control group (p=0.01, p=0.03, respectively). The SVDR levels were positively correlated with the BASDAI, CRP and ESR in the patient group (p=0.01, r=0.751; p=0.01, r=0.75; p=0.01, r=0.81, respectively). Conclusion: Our study results suggest that serum SVDR levels are associated with the disease activity and clinical parameters in patients with AS. Based on these findings, SVDR level may be used as a marker of disease activity in AS.
Serum Glucocorticoid-Inducible Kinase-1(SGK1) Levels in Patients with Psoriatic Arthritis
(2018) Keskin, Goksal; Inal, Ali; Keskin, Esra Dilek; Olmez, Umit; https://orcid.org/0000-0002-0690-2529; J-8056-2012