Browsing by Author "Karakas, Nazmi Mutlu"

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Congenital Hypothyroidism and Bone Remodeling Cycle
(2017) Karakas, Nazmi Mutlu; Kinik, Sibel Tulgar; Ozdemir, Beril; Sahin, Nursel Muratoglu; Tekindal, M.Agah; Haberal, Aysegul; 0000-0003-4286-7086; 27840329; AAX-3831-2020
Objective: The present study aimed to evaluate the biochemical markers of bone turnover in children with congenital hypothyroidism during the course of treatment as compared to healthy children selected as controls. Methods: The study included 31 children with congenital hypothyroidism and 29 healthy children. In both groups, we evaluated serum procollagen type-1 N-terminal propeptide (PINP) and tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels as bone turnover markers. Results: In both groups, thyroid hormone levels were within normal limits. The levels of vitamin D were significantly higher in the cases with congenital hypothyroidism. Although PINP levels were not found to be different, TRACP 5b levels which are related to osteoclastic activities were significantly higher in the control group. Conclusion: We did not detect an increase in bone resorption in patients with congenital hypothyroidism, despite long-term treatment with LT4. Our results suggest that with effective vitamin D treatment and thyroxin replacement, congenital hypothyroidism is not a deleterious factor for bone turnover.
The importance of attachment in infant and influencing factors
(2019) Karakas, Nazmi Mutlu; Dagli, Figen Sahin; 0000-0003-4286-7086; 31384141; AAX-3831-2020
Attachment is a pattern of interaction and communication established and developed between mother and baby. For the growth of mentally and physically healthy individuals, the mother is expected to create a suitable attachment starting before the birth and to maintain it afterwards. It is also necessary for the baby to establish appropriate and safe attachment towards the mother in a similar manner. There are several factors that affect the attachment. Also, some studies show that children with attachment problems also have problems in their future lives. Healthcare professionals need to be aware of these factors and evaluate the child in terms of healthy parental communication and child development in well-child visits. As a result of these evaluations, multidisciplinary approaches to the mother-child pair can be established and the child's health is protected mentally and physically for healthy generations.
May rotavirus vaccine be affect food allergy prevalence?
(2020) Karakas, Nazmi Mutlu; Arslan, Almina; Atalay, Ece; Ayli, Itir; Bagci, Zeynep Ilayda; Cesaretli, Sude; Koksal, Burcu Tahire; Yilmaz Ozbek, Ozlem; 0000-0002-2388-4158; 0000-0003-4286-7086; 0000-0001-9580-7656; 32530362; AAJ-7580-2021; AAX-3831-2020; AAF-2109-2021
Incidence of food allergy (FA) during nursing period is 6-8% globally and It is reported %5,7 in Turkey. In our study, the aim is to determine whether the prevalence of food allergy (FA) increases in children vaccinated against rotavirus. The files of 681 infants who are still followed-up were retrospectively evaluated. Children who did not come to our clinic for all of their well-child follow-up visits were excluded from the study. Moreover, children diagnosed with allergy before vaccination and children with known gastrointestinal system disease were excluded from the study. The number of patients diagnosed with food allergy after being vaccinated against rotavirus was 12 (1.76%). Three children had a family history of allergy. Of 12 patients who were diagnosed after vaccination, 3 (n:104) were vaccinated with pentavalent vaccine and 9 (n:507) with monovalent vaccine. In the monovalent vaccination group, food allergy was found in 9 children (1.55%), and in the pentavalent vaccination group, food allergy was found in 3 children (2.88%). The difference between the two vaccination groups in terms of food allergy prevalence was not significant (p> .05). Although it is believed that food allergy, and even cow's milk protein allergy (CMPA) prevalence increases in infants vaccinated against rotavirus, in this study, no significant increase was observed in the prevalence of food allergy after rotavirus vaccination. Both types of vaccine had similar rates to each other.
Mother-child attachment patterns in mothers with and without a history of adverse childhood experiences
(2020) Karakas, Nazmi Mutlu; Sari, Burcu Akin; Aksakal, Fatma Nur Baran; Ozdemir, Dilsad Foto; Dagli, Figen Sahin; 0000-0002-9730-7206; 0000-0002-9730-7206; S-3910-2019; A-7296-2013
According to attachment theory, infants establish an attachment bond that gives them confidence and comfort, and the figure of attachment forms a secure basis for the infant. A history of abuse and neglect in the mother can affect her style of attachment to her infant. The aim in the present study is to investigate mother-child attachment patterns in mothers with and without a history of abuse. Of the 94 mothers, 50% had a childhood history of abuse, and of these 47 mothers, 61.7% had experienced physical abuse, 53.19% had experienced emotional abuse, 29.78% had experienced negligence and 6.38% had experienced sexual abuse. There was no statistically significant difference between the groups with and without a history of abuse in this regard. When the attachment patterns of the mothers in the two groups with their own mothers were evaluated, there was a significant difference in terms of their attachment patterns with their fathers. Although no significant relationship was observed between the history of abuse and attachment pattern, mothers with a history of abuse in childhood exhibited an insecure attachment. Education level can be a protective factor in establishing an attachment pattern, while intergenerational interactions can be suggested to affect attachment patterns.
Serum Vitamin D Levels in Children with Recurrent Respiratory Infections and Chronic Cough
(2016) Ozdemir, Beril; Koksal, Burcu Tahire; Karakas, Nazmi Mutlu; Tekindal, Mustafa Agah; Ozbek, Ozlem Yilmaz; 0000-0003-2974-9579; 0000-0003-4286-7086; 0000-0001-9580-7656; 0000-0002-4060-7048; 26821547; AAJ-2034-2021; HKW-0623-2023; AAX-3831-2020; AAF-2109-2021; U-9270-2018
Objectives To evaluate serum vitamin D levels in cases of recurrent respiratory infections and chronic cough and to investigate the effect of vitamin D therapy on recurrence of the diseases. Methods This prospective observational study was performed by comparing serum vitamin D levels in children with recurrent respiratory infections, chronic cough and healthy children. One-hundred-one children with chronic cough, ninety-eight children with recurrent respiratory infections and one-hundred-twenty-four healthy children were enrolled in the study. A structured questionnaire was completed to collect data on demography, diet, duration of breastfeeding, vitamin D supplementation and family history for allergic diseases. In patients with low serum vitamin D levels (<20 ng/ml), vitamin D therapy was administered in addition to conventional treatment for the diseases. Patients were followed up for 6 mo and their complaints were evaluated. Results Mean serum 25( OH) vitamin D level in the recurrent respiratory infections group was 11.97 +/- 4.04 ng/ml, chronic cough group was 13.76 +/- 4.81 ng/ml and control group was 31.91 +/- 18.79 ng/ml. Comparison of serum 25( OH) vitamin D levels between the study groups revealed a statistically significant difference ( p < 0.05). 25( OH) D deficiency in children was associated with increased frequency of recurrent respiratory infections and chronic cough. Conclusions To conclude, administration of supplementary vitamin D may be useful in the treatment and preventation of recurrent respiratory infections and chronic cough.