Browsing by Author "Kara, Filiz"

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    Coating of silver nanoparticles on polyurethane film surface by green chemistry approach and investigation of antibacterial activity against S. epidermidis
    (2022) Kara, Filiz; Aksoy, Eda Ayse; Aksoy, Serpil; Hasirci, Nesrin; 0000-0002-5017-0783; AAC-5455-2020
    Silver nanoparticles with potential antibacterial properties are included in biomaterials for the production of medical devices, which are used for diagnoses or treatment purposes. The aim of the current study was coating the polyurethane (PU) films with silver nanoparticles (AgNPs) due to their antibacterial efficacy. PU films were first modified by chitosan (CH), treated with AgNO3 to let CH chelate with silver ions, and then treated with vitamin-C (vit C) or glucose (Glu) to reduce the adsorbed ions to atomic silver to form AgNPs. The surfaces of the films were examined by ATR-FTIR, XPS, XRD, and SEM. Chemical bond formation between CH and Ag ions and AgNPs were determined by ATR-FTIR. Meanwhile, XPS and SEM analyses proved the presence of reduced metallic silver and nanoparticles on the film surfaces, respectively. According to the SEM analyses, a homogeneous distribution of AgNPs, with sizes 99-214 nm and 37-54 nm, on the film surfaces were obtained depending on Glu or vit C reduction, respectively. The films presented excellent antibacterial performance against Gram positive Staphylococcus epidermidis (S. epidermidis). These results suggested that the mentioned green technology can be easily applied to obtain AgNP coated polymeric surfaces with very high antibacterial efficacy. Although there are some studies dealing with AgNP formation on PU sponges or fibers, to the best of our knowledge, this is the first study showing AgNP formation on the CH conjugated PU films.
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    Sözlü kara analizi yöntemi temelinde salgın durumlarında polimerik biyomalzeme üreten firmaların kalite performanslarının değerlendirilmesi
    (Başkent Üniversitesi Fen Bilimler Enstitüsü, 2022) Sepetci, Sümeyyenur; Kara, Filiz
    Salgın hastalıklar birçok alanı etkileyen kritik ve önemli olaylardır. Salgın süreçlerinde özellikle medikal ürünlerinin üretimi ve tedariği öne çıkmaktadır. Bu çalışmada, Covid-19 sürecinde, medikal ürünlerde kullanılan polimerik biyomalzemenin üretiminde etkilenen kalite performanslarının değerlendirilmesi amaçlanmaktadır. Literatür taraması ve sektör görüşmeleri ile üretimi etkileyen kalite performans kriterleri belirlenmiştir. Belirlenen kriterlerden soru listesi oluşturulmuş ve Ankara’da polimerik biyomalzeme üreticisi olan altı firmaya yöneltilmiştir. Alınan cevaplara, Entropi, ABC analizi ve ZAPROS metodu uygulanmıştır. Çalışma sonucu, firmaların üretim sürecindeki kalite performanslarındaki değişiklikleri içermektedir.Pandemics are critical and important events that affect many areas. In the pandemics processes, especially the production and supply of medical products come to the fore. In this study, it is aimed to evaluate the quality performances affected in the production of polymeric biomaterials used in medical products during the Covid-19 process. Quality performance criteria affecting production were determined through literature review and sector interviews. A list of questions was created from the determined criteria and directed to six companies that are polymeric biomaterial producers in Ankara. Entropy, ABC analysis and ZAPROS method were applied to the answers received. The result of the study includes the changes in the quality performances of the companies in the production process.