Browsing by Author "Jaradat, Maha"

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    Cystatin C-based Formula is Superior to MDRD, Cockcroft-Gault and Nankivell Formulae in Estimating the Glomerular Filtration Rate in Renal Allografts
    (Başkent Üniversitesi, 2009-12) Hejaili, Fayez; Sayyari, Abdulla A. Al; Tamimi, Waleed; Qutb, Ammar; Syed, Ghulam; Tamim, Hani M.; Jondeby, Mohammad Al; Jaradat, Maha; Ghamdi, Ghormullah Al; Qurashi, Salem Al; Flaiw, Ahmed
    Objectives: There are conflicting reports on the reliability of the various glomerular filtration rate formula in renal allografts, to assess the performance of various glomerular filtration rate formula in estimating renal function of renal allografts. Materials and Methods: Glomerular filtration rate was measured using an isotope Tc99m DTPA in 97 renal transplant patients and estimated using modification of diet in renal disease, Cockroft-Gault formula, Nankivell, and a cystatin C-based formula. The overall performance of these formula was evaluated by calculating bias, accuracy and precision. Results: Mean age was 39.8 years (± 12.7), body mass index was 26.9 (± 6.3) and serum creatinine was 114.5 µmol/L (± 39.3). The mean measured glomerular filtration rate was 58.1 mL/min (± 25.6). The bias with modification of diet in renal disease was 7.7 (P = .03), with Cockroft-Gault formula it was 3.2 (P = .3), with Nankivell it was 10.3 (P = .0002), and with cystatin C it was 0.31 (P = .9) The precisions (r) for modification of diet in renal disease, Cockroft-Gault formula, Nankivell, and cystatin C were 0.26 (P = .01), 0.26 (P = .01), 0.42 (P = .0001), and 0.60 (P < .0001), respectively. We also investigated the impact of sex, age, body mass index, and glomerular filtration rate on the performance of these 4 formula. Conclusion: The best correlation, highest precision, accuracy, and least bias were seen when using cystatin C. The largest bias was seen when using Nankivell and modification of diet in renal disease formula.
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    Effect of Fasting for Ramadan on Kidney Graft Function During the Hottest Month of the Year (August) in Riyadh, Saudi Arabia
    (Başkent Üniversitesi, 2012-12) Qurashi, Salem; Sayyari, Abulla Al; Jaradat, Maha; Tamimi, Abdulrahman
    Objectives: To assess the effect of fasting Ramadan during the hottest month of the year in Riyadh, Saudi Arabia. Materials and Methods: This prospective cohort study was performed at the King Fahd National Guard Hospital in Riyadh, Saudi Arabia. We used the Modification of Diet in Renal Disease formula to estimate the glomerular filtration rate in renal transplant patients who fasted and did not fast before and after Ramadan. Results: There were 43 fasters and 37 nonfasters of comparable ages, with fasters having longer posttransplant times compared with nonfasters (P = .0001). The 2 groups had similar mean estimated glomerular filtration rates before Ramadan: 75.6 ± 29.2 and 65.9 ± 25.9 mL/min (P = .1) and similar mean estimated glomerular filtration rates 6 months after Ramadan: 77.2 ± 29.7 and 64.1 ± 29 mL/min (P = .21). Mean changes in the estimated glomerular filtration rate were similar in the 2 groups: -1.5 ± 10.9 and -2.8 ± 19.3 (P = .7) as was the percentage change (-0.2.2 ± 13.4 and 1.8 ± 15.9; P = .4). In the fasting group, serum creatinine and estimated glomerular filtration rate were similar before and 6 months after Ramadan: 105.1 ± 55 and 105.14 ± 61 µmol/L (P = 1.0) and 75.6 ± 29 and 72.2 ± 29.7 mL/min (P = .36). No significant changes were observed in the nonfasting group. No significant differences were detected regarding fasting in the estimated glomerular filtration rate before and 6 months after Ramadan in the 3 groups with the low, moderate, and high glomerular filtration rates at baseline. Conclusions: Fasting for Ramadan in August does not adversely affect graft function at a mean follow-up of 7.6 ± 1.3 months.