Browsing by Author "Isik-Ulusoy, Selen"

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Evaluation of affective temperament and anxiety-depression levels in fibromyalgia patients: a pilot study
(2019) Isik-Ulusoy, Selen; 0000-0003-2550-8989; 30994852
Objective: Fibromyalgia (FM) patients have higher rates of depression and anxiety disorders than healthy controls. Affective temperament features are subclinical manifestations of mood disorders. Our aim was to evaluate the affective temperaments of FM patients and investigate their association with depression and anxiety levels and clinical findings. Methods: This cross-sectional study included FM patients and healthy controls. The Hospital Anxiety and Depression Scale (HADS) was used to determine patient anxiety and depression levels, and the Temperament Scale of Memphis, Pisa and San Diego, self-administered version was applied to assess affective temperaments in all subjects. Disease severity was assessed in FM patients with the Fibromyalgia Criteria and Severity Scales and the Fibromyalgia Impact Questionnaire (FIQ). Differences between groups were evaluated using Student's t-tests. Correlations among parameters were performed. Results: This study involved 38 patients with FM (30 female) and 30 healthy controls (25 female). Depressive, anxious and cyclothymic temperaments were significantly higher in FM patients than healthy controls. Statistically significant positive correlations were found between HADS depression score and all temperaments except hyperthymic, as well as between HADS anxiety score and cyclothymic and anxious temperaments. HADS depression and anxiety scores were correlated with symptom severity. We found a higher risk of depression and anxiety among FM patients with higher FIQ scores. Conclusion: This study is the first to evaluate affective temperament features of FM patients. Evaluating temperamental traits in FM patients may help clinicians determine which patients are at risk for depression and anxiety disorders.
Evaluation of dry eye disease in newly diagnosed anxiety and depression patients using anterior segment optical coherence tomography
(2019) Ulusoy, Mahmut Oguz; Isik-Ulusoy, Selen; Kivanc, Sertac Argun; 31417939
Background We aimed to evaluate dry eye diseases (DED) in patients with newly diagnosed depression and anxiety patients. Methods Forty newly diagnosed depression, 35 anxiety patients, and 37 controls without any history of taking psychiatric drugs (or before the beginning of psychiatric medication) and topical ophthalmic drop use, were included in the study. All depression and anxiety diagnoses were performed by an experienced psychiatrist. Beck depression and anxiety tests were used to measure disease severity. Tear film break up time (TBUT), Schirmer's test, Oxford scores and ocular surface disease index (OSDI) were admiinistered to participants. Anterior segment optical coherence tomography was used to measure tear meniscus heights (TMH), tear meniscus depths (TMD) and tear meniscus areas (TMA). Results In anxiety and depression groups, Schirmer's test (mm) (7.24 +/- 6.02, 6.58 +/- 4.9 and 18.79 +/- 4.9 respectively, p < 0.05) and TBUT (s) (5.62 +/- 3.1, 5.6 +/- 3.5 and 13.37 +/- 1.7 respectively, p < 0.05) were significantly lower than control group. In addition, OSDI and Oxford scores were significantly higher than controls. OSDI scores were 28.01 +/- 19, 30.43 +/- 18.49, 14.38 +/- 8.14 respectively (p = 0.002) and Oxford scores were 1.9 +/- 0.7, 2.1 +/- 0.6 and 0.7 +/- 0.4 respectively (p = 0.001). TMD, TMH and TMA values were significantly lower in anxiety and depression groups compared with control groups. Correlations between disease inventory scores and dry eye tests were detected. Conclusions This study showed a relation between DED and newly diagnosed anxiety and depression patients with no history of psychiatric drug use. The presence of correlation between dry eye tests and disease inventory scores strengthens this association. This is an important knowledge that need to be evaluated in these patients before starting psychiatric medication.
Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis
(2020) Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Isik-Ulusoy, Selen; 32048550
Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS). Methods: A total of 20 patients with relapsing remitting multiple sclerosis (RRMS) and 24 healthy controls were recruited in this study. All participants' superficial and deeper retinal and peripapillary layers were evaluated using OCTA after a total ophthalmologic examination. Results: In the superficial plexus, the whole image (49.53 +/- 3.9% and 51.83 +/- 2.1%, p = 0.009), superior hemisphere (49.44 +/- 4.11% and 51.63 +/- 2.3%, p = 0.018), inferior hemisphere (49.75 +/- 3.9% and 52.03 +/- 2.2%, p = 0.012), parafoveal (51.87 +/- 3.9% and 53.08 +/- 3.46%, p = 0.048) and perifoveal (50.41 +/- 3.86% and 52.76 +/- 2.1%, p = 0.007) vascular densities were statistically significant lesser in patients with RRMS than in controls. In the optic disc OCTA parameters, the vessel density of the inferior (50.15 +/- 6.99% and 53.04 +/- 3.63% p = 0.043) and temporal sector (48.09 +/- 5.47% and 50.85 +/- 5.24%, p = 0.045) were statistically significantly lesser in patients with RRMS than in controls. Conclusion: The reductions in vessel density of the retinal or peripapillary area of patients with RRMS shown in this study should be investigated further to determine whether it is a secondary lesion to optic neuritis (ON) or a primary vasculopathic condition of MS.