Browsing by Author "Ipekci, Tumay"

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Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. Letter
(2021) Coner, Ali; Ipekci, Tumay; 33835864
Changes in Expressions of ADAM9, 10, and 17 As Well as Alpha-Secretase Activity in Renal Cell Carcinoma
(2017) Erin, Nuray; Ipekci, Tumay; Akkaya, Bahar; Ozbudak, Irem Hicran; Baykara, Mehmet; https://orcid.org/0000-0002-2755-0526; https://orcid.org/0000-0001-6687-1587; 27692848; AAB-2986-2020; C-4815-2016
Background: ADAM9, 10, and 17 are a class of disintegrins and metallproteinases with oc-secretase activity. There are conflicting results regarding the role(s) of ADAM9, 10, and 17 in carcinogenesis, and only a few studies have examined their levels and cellular localization in renal cell carcinoma (RCC). Studies examining changes in oc-secretase activity in RCC compared to enzymatic activity of the uninvolved kidney are lacking. Method: A cross-sectional study was conducted in 56 patients undergoing radical nephrectomy after the diagnosis of RCC. alpha-Secretase activity was determined using flourogenic substrate in freshly frozen tumor tissues as well as similarly treated tissues from the neighboring kidney. Immunohistochemical analyses of ADAM9, 10, and 17 were also performed. Results: alpha-Secretase activity decreased markedly in all types of RCC as compared to neighboring uninvolved kidney tissue having 5 to 10 times higher levels of oc-secretase activity. Although type-dependent variations were observed, tumoral expressions of ADAMs, except for ADAM17, were lower in the tumors compared to that of neighboring tissues, but the changes in oc-secretase activity were greater. In RCC tissue, ADAM9 expressions were localized in nuclear and cytoplasmic compartments, whereas ADAM10 and 17 were present predominately in the cytoplasm potentially explaining the markedly decreased enzyme activity. Membranous localization of ADAMs was noted in uninvolved kidney tissue. Conclusions: The loss of alpha-secretase activity observed here in conjunction with previous findings argue against tumorigenic effects of ADAM9, 10, and 17 supporting that increased nuclear and cytoplasmic expression may be an attempt to compensate for loss of function. (C) 2017 Elsevier Inc. All rights reserved.
Clinical and Bacteriological Efficacy of Amikacin in The Treatment of Lower Urinary Tract Infection Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli or Klebsiella Pneumoniae
(2014) Ipekci, Tumay; Seyman, Derya; Berk, Hande; Celik, Orcun; https://orcid.org/0000-0002-2755-0526; 25179392; AAB-2986-2020
Urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria have become a growing problem limiting therapeutic options. The aim of this study was to investigate the clinical and microbiological efficacy of amikacin treatment in adult patients with lower UTIs due to ESBL-producing Escherichia coli (Ec) or Klebsiella pneumonia (Kp). We conducted a retrospective study of 36 outpatients aged >18 years with dysuria or problems with frequency or urgency in passing urine; pyuria and a positive urine culture (10(5) cfu/ml) for ESBL producing Ec or Kp which is also resistant to nitrofurantoin, fosfomycin, quinolones and trimethoprim/sulfamethoxazole, between January 2013 and February 2014. Patients received intramuscular amikacin 15 mg/kg/day for 10 days. Clinical success was defined as disappearance of symptoms. Bacteriological success was defined as sterile control urine cultures. 58.3% of patients were female. Age range was 18-89 years. All of the patients had at least one complicating factor. 77.8% of the isolates were E. coli. Clinical success rate was 97.2%. Overall bacteriological success rates were 91.7% on the 3 day of treatment, 97.1% at the end of the treatment and 94.1% on the 7-10 days after treatment. After 28-32 days following the treatment, reinfection was found in 12% whereas relapse was not determined. Nephrotoxicity was developed in one patient. The clinicians should keep in mind that amikacin treatment is an efficient and safe alternative treatment option before the carbapenem treatment especially in patients with lower UTIs caused by ESBL-producing Ec or Kp that are resistant to all oral antibiotics. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Comparison of Glomerular Filtration Rate Measurements with Two Plasma and Single Plasma Sample Methods in Renal Transplant Cases with Stable Renal Graft Functions
(2015) Oner, Ali Ozan; Aydin, Funda; Ipekci, Tumay; Sipahi, Murat; Suleymanlar, Gultekin; Gungor, Firat; 0000-0002-2755-0526; 25643901; AAB-2986-2020
This study was planned to determine the efficacies of single plasma sample methods (SPSMs) in indicating glomerular filtration rate (GFR) by taking two plasma sample method (TPSM) as reference in the determination of the GFR in cases with clinically stable renal transplantation. Ninety-six renal transplantation cases (33 female, 63 male; age interval 18-67, mean age 37.46 +/- A 11.81 years) progressing stably clinically and as laboratory, with minimum 6 months after transplantation were included in the study. The GFR values of the cases were measured with SPSM and TPSM. It is observed that all SPSMs have a strong correlation with TPSM. Highest correlation was observed between Groth&Aasted SPSM and TPSM GFR (intraclass correlation coefficient: 0.965). In the analyses performed by using the Bland-Altman analysis, GFR values calculated by all SPSMs were concordant to the TPSM which is the gold standard method in 95 % confidence interval (average +/- A 1.96 standard deviation) and were within the clinically acceptable limits. The narrowest concordance interval was obtained between Groth&Aasted Tc-99 m DTPA SPSM and Tc-99 m DTPA TPSM..Besides, we have obtained the minimum bias and precision value by the Groth&Aasted method. As a result; we can see that all the SPSMs give reliable results in measuring GFR in cases with renal transplantation; besides, we suggest Groth&Aasted method as the first option.
Continuous positive airway pressure therapy is associated with improvement in overactive bladder symptoms in women with obstructive sleep apnea syndrome
(2016) Ipekci, Tumay; Cetintas, Gulgun; Celik, Orcun; Ekin, Rahmi Gokhan; Sarac, Sema; Tunckiran, Ahmet; Ilbey, Yusuf Ozlem; 27123331
Introduction To evaluate the impact of continuous positive airway pressure (CPAP) therapy on overactive bladder (OAB) symptoms in women with obstructive sleep apnea syndrome (OSAS). Material and methods One-hundred and fifty women underwent an overnight polysomnography study between May 2014 and September 2014. Their voiding symptoms were evaluated using the OAB symptom score (OABSS) and International Consultation on Incontinence Questionnaire Short-Form at OSAS diagnosis and approximately 3-months after CPAP therapy. OSAS severity was assessed according to the apnea-hypopnea-index. Results We evaluated 140 women and 111 of them (79.3%) reported symptoms consistent with OAB. There were no statistically significant differences between OSAS severity with a prevalence of OAB (p = 0.92). The prevalence of urinary incontinence (UI) was 35.7% (n = 50) and 39.6% (n = 44) in all patients and patients with OAB, respectively. There were no statistically significant differences between UI with OAB (p = 0.58). Baseline OABSS is comparable between OSAS severity (p = 0.143). After 3-months CPAP therapy, OABSS and ICIQ-SF sum scores were significantly decreased in patients with severe and moderate OSAS (p < 0.01), however, change of OABSS sum score was insignificant in patients with mild OSAS (p = 0.44). Conclusions CPAP therapy improves the OAB, OABSS and ICIQ-SF scores in women with severe and moderate OSAS. OSAS-induced OAB may be alleviated following CPAP therapy.
Diagnosis and treatment in primary bladder small cell carcinoma: Literature review
(2016) Celik, Orcun; Ekin, Gokhan; Ipekci, Tumay; Budak, Salih; Ilbey, Yusuf Ozlem; 27072176
Small cell bladder carcinoma is a rare and frequently fatal disease. It can be distinguished from classical urothelial carcinoma microscopically and immunohistochemically. Small cell bladder carcinoma has histologically similar properties with other small cell carcinomas in other organs. It has a worse prognosis when compared to urothelial bladder cancer. Multimodal treatments are recommended although there is no widely accepted consensus regarding to the treatment algorithm because of its rarity. In this review, clinical properties and diagnosis of small cell bladder carcinoma, its histopathological and immunohistochemical properties and treatment modalities are examined.
Efficacy of Silodosin in the Treatment of Distal Ureteral Stones 4 to 10 Mm in Diameter
(2015) Yuksel, Mustafa; Yilmaz, Serdar; Tokgoz, Husnu; Yalcinkaya, Soner; Bas, Serkan; Ipekci, Tumay; Yildiz, Ali; Ates, Nihat; Savas, Murat; 0000-0002-3068-4699; 0000-0002-2755-0526; 0000-0003-0293-9989; 26770537; AAD-5570-2019; AAB-2986-2020; GWC-8116-2022
Purpose: Few studies have investigated the efficacy of silodosin, a recently introduced selective alpha 1-A adrenoceptor antagonist, in medical expulsive therapy (MET) for ureteral calculi. The results of these studies, which all evaluated the efficacy of 8 mg/day, indicate that silodosin is a potential treatment for ureteral calculi. This study investigated the efficacy of 4 mg/day of silodosin for MET of distal ureteral stones 4 to 10 mm in diameter. Material and Method: After 70 patients had been randomized into 2 groups of 35 patients each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for pain relief but only the experimental group to take 4 mg/day of silodosin. After 21 days, the groups were compared regarding the stone expulsion rate and duration, number of renalcolicepisodes, and analgesicdosage. Results: The median expulsion rates were 71.4% and 91.4% in groups 1 and 2, respectively, and the difference between them was significant (P= 0.031). The median expulsion durations were 12.91 +/- 6.14 and 8.03 +/- 4.99 days, respectively, and the difference between them was significant (P< 0.001). No significant differences were found regarding the median number of renal colic episodes or median analgesic dosage. While no patients in group 1 experienced side effects, 5 patients (14%) in group 2 experienced retrograde ejaculation. Conclusion: These results indicate that 4 mg/day of silodos in facilitates the expulsion of distal ureteral stones 4 to 10 mm in diameter but does not significantly reduce the number of renal colic episodes or analgesic dosage.
An Extremely Rare Cause of Hematuria: Adamantinoma like Neuroectodermal Tumor of Bladder
(2016) Yilmaz, Serdar; Ipekci, Tumay; Akin, Yigit; https://orcid.org/0000-0002-2755-0526; AAB-2986-2020
Primary primitive neuroectodermal tumour (PNET) is a rare entity and have severe malign potential. However, PNET is derived from central nervous system, it can rarely occur in another soft tissue. Herein, we present an extremely rare cause of hematuria in an 83-year-old man, who was diagnosed as adamantinoma like PNET, in bladder. After transurethral surgical treatment, there was no recurrence, in short-term clinical follow-up. According to our best knowledge, he was the oldest patient who had PNET in bladder, in published literature.
An Extremely Rare Kidney Tumor: Primary Intraparenchymal Squamous Cell Carcinoma
(2017) Ipekci, Tumay; Yuksel, Mustafa; Yildiz, Ali; Inal, Gulsah; Ipekci, Oncel; 0000-0002-2755-0526; AAB-2986-2020
Primary squamous cell carcinoma of the renal parenchyma is a rare entity and only 4 cases have been reported in the literature. A 73-year-old female patient presented to our clinic with the complaint of right flank pain. On radiologic evaluation, a 6x5x4 cm hypodense mass showing heterogeneous contrast enhancement was observed in the upper pole of the right kidney. An uneventful laparoscopic radical nephrectomy was performed. Final pathologic diagnosis was squamous cell carcinoma. No pathological involvement was observed on postoperative positron emission tomography/ computed tomography. Our patient is still alive and she has not received any adjuvant treatment.
Goserelin Treatment and Blood Loss Associated with Transurethral Resection of the Prostate
(2015) Ipekci, Tumay; Unal, Betul; Hoscan, Mustafa Burak
Holmium laser enucleation of the prostate: surgical, functional, and quality-of-life outcomes upon extended follow-up
(2016) Alkar, Ilter; Ozveri, Hakan; Akin, Yigit; Ipekci, Tumay; Alican, Yusuf; 27256184
Objectives: To evaluate the long-term surgical, functional, and quality-of-life (QoL) outcomes after Holmium laser enucleation of the prostate (HoLEP) in patients with symptomatic benign prostatic hyperplasia (BPH). Materials and Methods: We retrospectively reviewed recorded data on patients who underwent HoLEP between June 2002 and February 2005. Ninety-six patients were enrolled. Demographic, perioperative, and postoperative data were recorded. On follow-up, International Prostate Symptom Scores (IPSSs), prostate-specific antigen (PSA) levels, QoL scores, peak uroflowmetric data (Q(max) values), and post-voiding residual urine volumes (PVR volumes), were recorded. Complications were scored using the Clavien system. Statistical significance was set at p<0.05. Results: The mean follow-up time was 41.8 +/- 34.6 months and the mean patient age 73.2 +/- 8.7 years. The mean prostate volume was 74.6 +/- 34.3mL. Significant improvements in Q(max) values, QoL, and IPSSs and decreases in PSA levels and PVR volumes were noted during follow-up (all p values=0.001). The most common complication was a requirement for re-catheterisation because of urinary retention. Two patients had concomitant bladder tumours that did not invade the muscles. Eight patients (8.3%) required re-operations; three had residual adenoma, three urethral strictures, and two residual prostate tissue in the bladder. Stress incontinence occurred in one patient (1%). All complications were of Clavien Grade 3a. We noted no Clavien 3b, 4, or 5 complications during follow-up. Conclusions: HoLEP improved IPSSs, Q(max) values, PVR volumes, and QoL and was associated with a low complication rate, during extended follow-up. Thus, HoLEP can be a viable option to transurethral resection of the prostate.
Iatrogenic Urethral Defect Repairment
(2015) Ipekci, Tumay; Hoscan, Mustafa Burak
The impact of Technetium-99m dimercapto-succinic acid scintigraphy on DNA damage and oxidative stress in children
(2021) Varol, Selcuk; Oktem, Faruk; Kocyigit, Abdurrahim; Demir, Aysegul Dogan; Karatas, Ersin; Aydin, Mehmet; Goknar, Nilufer; Ipekci, Tumay; 34487588
Background Technetium-99m-dimercapto succinic acid (Tc-99m DMSA) scintigraphy is a commonly used imaging modality in children with urological abnormalities. The radiopharmaceuticals, which have the effects of ionising radiation, are used in this method. This study aimed to investigate the impact of the Tc-99m DMSA scan on renal oxidative stress and mononuclear leukocyte (MNL) DNA damage. Methods Children, who were followed up by paediatric nephrology at Bezmialem Vakif University and underwent Tc-99m DMSA scintigraphy between April 2015 and January 2016 with the indication of detection of renal scars, were included in this study. The exclusion criteria were nephrolithiasis, history of premature birth and recent urinary tract infection 3 months prior to scintigraphy or antibiotic use in the last 1 month. 3 mL heparinised blood samples were obtained just before, immediately after and 1 week after the scintigraphy. MNL DNA damage, total antioxidant status (TAS) and total oxidant status (TOS) were measured in the blood samples. The oxidative stress index (OSI) was calculated. Spot urine samples were obtained from each patient before and within 3 days after performing the scintigraphy. TAS/Creatinine (TAS/Cr), TOS/Creatinine (TOS/Cr) and N-acetyl-glucosaminidase/creatinine (NAG/Cr) levels were measured in the urine samples. Results Twenty-seven children were evaluated. The values between TAS, TOS and OSI levels in serum samples at baseline, immediately after and 1 week after the scintigraphy (P = .105, P = .913, and P = .721, respectively) showed no statistically significant difference. The levels of TAS/Cr, TOS/Cr, NAG/Cr ratios and OSI, which were evaluated from urine samples before and within 3 days after the scintigraphy scan were also similar (P = .391, P = .543, P = .819 and P = .179, respectively). The levels of DNA damage only increased following scintigraphy scan and decreased a week later (P < .05). Conclusions The effect of Tc-99m DMSA scintigraphy is insufficient to create oxidative damage, but it can cause DNA damage via the direct impact of ionising radiation which can be repaired again in a short time.
Is Preoperative Neutrophil Lymphocyte Ratio a Reliable Prognostic Parameter for Localized Prostate Cancer?
(2017) Ipekci, Tumay; Tunckiran, Ahmet; Yuksel, Mustafa; Ucar, Murat; Kozacioglu, Zafer; Akman, Ramazan Yavuz; 0000-0001-7303-7064; 0000-0002-2755-0526; V-6440-2019; AAB-2986-2020; AAD-3028-2020
Objective: In spite of all efforts, prostate cancer is still the 2nd highest cause of cancer-related deaths in men. For this reason new developments are needed in diagnosis, treatment and follow-up of prostate cancer. Neutrophil/lymphocyte (N/L) ratio is a cheap and effective parameter used for research into many solid tumors; but there are not enough studies on the reliability of this parameter in prostate cancer. In this study we researched the efficacy of N/L ratio in localized prostate cancer. Materials and Methods: Between March 9, 2012 and April 23, 2017, the data of 140 patients who underwent radical prostatectomy with localized prostate cancer were screened retrospectively. The patients' ages, preoperative prostate specific antigen (PSA) and N/L ratio, pathologic stage, pathologic Gleason score, tumor volume, lymph node involvement, surgical margin positivity and presence or absence of 3rd month biochemical recurrence were noted. The correlations between N/L ratio with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence were investigated. Results: The mean age of patients was 63.0 +/- 5.9 years, mean PSA value was 10.8 +/- 8.5 ng/mL and mean N/L ratio was 2.5 +/- 1.9. There was no correlation found between N/L ratio and PSA, pathologic stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity and biochemical recurrence (p>0.05). Conclusion: In our study investigating 140 patients with localized prostate cancer, we did not identify any correlation between N/L ratio and PSA, surgical stage and Gleason score, surgical margin positivity, and 3rd month biochemical recurrence. When the literature is investigated, it appears that N/L ratio is effective for metastatic prostate cancer. To provide a more accurate judgment of the role of N/L ratio in localized prostate cancer, there is a need for new studies with broader patient series.
Penile traction therapy for Peyronie's disease-what's the evidence?
(2016) Usta, Mustafa Faruk; Ipekci, Tumay; 27298777
Penile traction therapy (PTT) is a new therapeutic option for men with Peyronie's disease (PD). However, it has a long history of use in other fields of medicine including bone, skin, skeletal muscle, and Dupuytren's. Mechanotransduction, or gradual expansion of tissue by traction, leads to the formation of new collagen tissue by cellular proliferation. As a molecular result, continuous extension of the fibrous plaque causes significant increases in collagenase and metalloproteinases, and, ultimately, to fibrous plaque softening and extension. This hypothetical knowledge has been supported by recent well designed experimental studies. Furthermore, several clinical papers have provided promising results on the use of PTT in PD patients. It has been shown in some series that the use of PTT significantly increases flaccid and stretched penile lengths and results in significant penile curvature improvement when compared to baseline. Furthermore, the use of PTT concomitantly with either verapamil or interferon alpha-2b has also been shown to be an effective therapy. Additionally, the beneficial effect of PTT on penile length before or after penile surgery in men with corporal fibrosis has been described. Finally, as a minimally invasive alternative treatment option to penile augmentation surgery in men with dysmorphophobia, PTT use has shown promising results by several experts. Studies have shown that PTT provides an acceptable, minimally invasive method that can produce effective and durable lengthening of the penis in men complaining of a small/short penis. There are, however, several criticisms related to the designs of the reported studies, such as small sample size and selection bias. Well-designed studies with larger numbers of patients and longer follow-up periods are, however, needed to establish the true benefits of PTT.
Predictors of Pain During Cystoscopy
(2015) Ipekci, Tumay; Akin, Yiğit; Hoscan, Mustafa Burak
Publication Rates and Citation Analysis of Oral and Poster Presentations at the First Congress of the Society of Urological Surgery in Turkiye
(2018) Ipekci, Tumay; Yuksel, Mustafa; Karamık, Kaan; Anil, Hakan; Tunckiran, Ahmet; 0000-0002-2755-0526; 0000-0001-7303-7064; AAB-2986-2020; V-6440-2019
Objective: Publications of congress presentations (oral/poster) contribute to the literature by creating new information. In this study, we examined the publication rate of poster and oral presentations at the 1st Congress of the Society of Urological Surgery in Turkiye held in 2012. Materials and Methods: We investigated the congress booklet belonging to the 1st Congress of the Society of Urological Surgery in Turkiye held in 3-7 October 2012. We investigated the publication rates of 176 poster and 103 oral presentations under the headings of uro-oncology, andrology, pediatric urology, endourology, transplantation, continence and other by searching the PubMed and Science Citation Index Expanded (SCI-E) databases. Results: Of the 176 poster and 103 oral presentations, 79 (28.3%) were subsequently published. The publication rate in journals included in the SCI-E was 24.3%. While 33% of oral presentations were published, 25.5% of poster presentations became publications and this difference was not found to be statistically significant (p= 0.48). The mean duration from presentation to publication was 21.1 months. Conclusion: The publication rate of presentations at the 1st Congress of the Society of Urological Surgery in Turkiye was higher than in most national congresses in different disciplines, but lower than many international congresses in the field of urology. Future studies investigating congress data from several consecutive years will provide clearer results.
Publication rates of dissertations written in medical faculties of Turkey in the field of urology between the years 2008, and 2011, and citation analysis: A cross-sectional study
(2018) Ipekci, Tumay; Tunckiran, Ahmet; Yuksel, Mustafa; 29799403; V-6440-2019
Objective: In our country, preparing dissertation is essential for the research assistants in order to complete their expertise in medicine. It is aimed to produce hypothesis for researchers via writing their dissertations, to collect data for the hypothesis established, to make the analysis and interpretation of these data, and to gain the ability for the comparison of the findings obtained with the literature. In this study, we want to investigate the publication rates and citations of urology dissertations that are written at the university hospitals in our country between 2008 and 2011. Material and methods: Urology dissertations that are written at the university hospitals between 2008 and 2011 were reviewed by entering the website of Board of Higher Education Dissertation between 23-27 March 2017 and 229 dissertations were reported. The publication rates of these dissertations were analysed. Results: Hundred and fourteen of 229 dissertations (49.7%) analysed were published. Of these publications, 75 (32.7%) in Science Citation Index Expanded, 24 (10.4%) in international, 15 (6.5%) are published in national indexed peer-reviewed journals. While the publication rate of 81 dissertations written in universities located in 3 metropolitan cities (Istanbul, Ankara, and Izmir) of Turkey was 50.6%, the publication rate of 148 dissertations written in remaining universities was 49.3%; and no statistically significant difference was found between the two groups (p=0.96). Conclusion: Preparing dissertation is a challenging process that requires considerable effort and time. At the end of this process, it is necessary to publish the dissertation in order to have it reach more people and to contribute to the literature. Even though publication rate of dissertations written in urology at university hospitals in Turkey was at acceptable level, there have still been problems required to solve.
Relationship Between Vesicoureteral Reflux and Bladder Compliance
(2015) Ipekci, Tumay; Celik, Orcun; Hoscan, Mustafa Burak
Retroperitoneal paraganglioma presenting as right-sided varicocele: case report
(2016) Ates, Nihat; Yuksel, Mustafa; Yilmaz, Serdar; Habibi, Mani; Ipekci, Tumay; 0000-0002-2755-0526; 26997533; AAB-2986-2020
Varicocele, the most important identifiable pathological cause of male infertility, is rarely observed on the right side. In isolated cases of right-sided varicocele, the presence of retroperitoneal masses compressing the inferior vena cava should be considered by further investigation. The retroperitoneal masses that are detected tend to grow rapidly due to their location and may be very large at the time of diagnosis. Soft tissue sarcomas are the most common cause of retroperitoneal masses, while paragangliomas are rare causes. Retroperitoneal paragangliomas should be diagnosed via detection of symptoms caused by hormonal activity, observation of the compression effect of the mass, or incidentally during imaging studies. SIMILAR CASES PUBLISHED: This study presents the first case of retroperitoneal paraganglioma in a 41-year old man as isolated right-sided varicocele that has been described in the published reports.