Browsing by Author "Inal, A."

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    Investigating The Role of Il-33 in The Pathogenesis of Behcet's Disease
    (2016) Keskin, G.; Tutluer, S.; Cerci, P.; Kose, K.; Olmez, U.; Inal, A.; https://orcid.org/0000-0002-0690-2529; J-8056-2012
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    Investigating the Role of Il-33 in the Pathogenesis of Behcet's Diseast
    (2016) Keskin, G.; Inal, A.; Tutluer, S.; Cerci, P.; Kose, K.; Olmez, U.; 0000-0002-0690-2529; J-8056-2012
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    Ligasure® Versus Clamp Tie Technique For Thyroid Surgery; Decreased Operative Time Versus Increased Inflammatory Effect: A Prospective Randomized Study
    (2014) Bircan, H. Y.; Inal, A.; Ozcelik, U.; Koc, B.; Demirag, A.; Moray, G.; Kemik, O.; https://orcid.org/0000-0002-0690-2529; https://orcid.org/0000-0003-1073-2494; https://orcid.org/0000-0003-2498-7287; 25027338; R-6394-2019; J-8056-2012; AAG-8651-2021; AAE-1041-2021
    OBJECTIVE: The aim of this study was to compare the LigaSure (R) Small Jaw Instrument (LSJI) with the conventional clamp-and-tie (CT) technique in thyroid surgery regarding complication rates (hematoma, hypocalcemia and recurrent nerve palsy), the duration of the operative procedure, and systemic and local inflammatory effects. PATIENTS AND METHODS: Fifty-four consecutive patients were randomized prospectively into two groups, a Conventional Clamp-Tie (CT) group and a LigaSure (R) Vessel Sealing System (LVSS) Group. Pre- and postoperative blood plasma samples were taken to measure the tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), calcium, parathormon, CRP levels and WBC, as well as the lymphocyte subset (CD3, CD4, CD8, CD16/56, CD19) counts. The drain fluid samples were collected after the removal of the drains to measure the levels of IL-6 and TNF-alpha. RESULTS: Both groups showed significant changes regarding peripheral blood CD3+, CD4+, and CD8+ T cell levels (p < 0.05). In the LVSS group, the level of CD16+56+ NK cells showed a significant decrease compared with the CT group (p < 0.05). The IL-6 and TNF-alpha levels in the drainage fluid were significantly higher in the LVSS group. CONCLUSIONS: We demonstrated that LSJI can decrease operative time. Although the systemic inflammatory effect of LSJI remains inconclusive, the local inflammatory effect was significant, which could cause early and late postoperative problems.
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    Serum Angiostatin Levels in Patients with Behcet's Disease: Does Angiogenesis Play A Role in The Pathogenesis of Behcet's Disease?
    (2014) Keskin, D.; Keskin, G.; Inal, A.; Ozisik, L.; https://orcid.org/0000-0002-0690-2529; 25012748; J-8056-2012
    Angiogenesis plays an important role in the pathogenesis of inflammatory diseases, but the possible role of angiogenesis in Behcet's disease (BD) has not yet been studied. The aim of this study was to determine angiostatin levels in patients with BD and the role of angiogenesis in the pathogenesis of the disease. Thirty-seven patients with BD (mean age: 28.6 +/- 5.4 years, mean disease duration: 9.3 +/- 3.7 years) and 18 healthy controls were enrolled to the study. Twenty-four patients were in active and 13 patients were in inactive stage of the disease. The mean serum angiostatin level of patients with BD was 113.9 +/- 653.2 and 60.7 +/- 20.1 ng/ml in healthy controls. The mean serum angiostatin level was 142.7 +/- 43.1 ng/ml in active and 86.9 +/- 15.5 ng/ml in inactive patients with BD. Serum angiostatin levels were significantly high in patients with BD compared with healthy controls (P<0.001) and it was significantly high in active patients compared with inactive patients with BD (P<0.001). In inactive patients with BD, serum angiostatin concentrations were found to be higher compared with healthy controls (P<0.01). In active BD patients, the mean serum angiostatin level was correlated with the deep vein thrombosis (r=0.482, P=0.05), uveitis (r=0.582, P=0.01), and arthritis (r=0.492, P=0.05). According to these results; elevated serum angiostatin levels in patients with BD suggest the possible role of angiogenesis in the pathogenesis of the disease and its high levels in inactive Behcet's patients is related with the continuous activation of the disease even in the subclinical period.
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    Serum Glucocorticoid-Inducible Kinase-1(SGK-1) Levels in Patients with Ankylosing Spondylitis
    (2018) Keskin, G.; Inal, A.; Olmez, U.; https://orcid.org/0000-0002-0690-2529; J-8056-2012