Browsing by Author "Haberal, Erdem"

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    Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment
    (2020) Alpdemir, Sukran; Vural, Tayfun; Kara, Goknur; Bayram, Cem; Haberal, Erdem; Denkbas, Emir Baki; 0000-0003-2788-550X; 33010138; ABC-8833-2020
    This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated in alginate microspheres together with an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesised and characterised by dynamic light scattering, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. Then, alginate-SPIONs microspheres were developed, and further characterised by electron spin resonance spectrometer and vibrating sample magnetometer. Besides the magnetic properties of SPIONs, alginate microspheres with SPIONs were also found to have magnetic properties. The potential use of microspheres in hyperthermia treatment was then investigated and an increase of about 4 degrees C in the environment was found out. Drug release studies and cytotoxicity tests were performed after sorafenib was encapsulated into the magnetic microspheres. According to release studies, sorafenib has been released from microspheres for 8 h. Cytotoxicity tests showed that alginate-SPION-sorafenib microspheres were highly effective against cancerous cells and promising for cancer therapy.
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    A Novel Portable Nanotechnology Approach for Targeted Cancer Therapy
    (2018) Bunyatova, Ulviye; Kocum, Cengiz; Haberal, Erdem; Asadullayev, Alaskar; Salamov, Gulbala; 0000-0003-2788-550X; ABC-8833-2020
    Several health-related problems can be monitored, treated and minimized with the use of technological equipment and treatment methods. The development of new synthesis methods and designing nanostructured biosensing colloidal polymeric bioorganic nanomaterials and metal using cheap and environmentally friendly methods remains a challenge to the scientific community. This study is focused on the presentation a new approaches to targeted treatment with a novel portable sensing system. We have found that aqueous blend of intercalated polysaccharides nanocomposites with a reactive functionalizing copolymer and silver nanoparticules (AgNP-s) are sensitive towards a visible light source-white light emitted diode (wLED). The presented system and ideas can be used as an integrated pathways for targeted cancer therapy, biosensors, and drug delivery systems. AgNP-s, having unique sizes in the range between 2 -6 nm have been obtained by the influence of harmless wLED treatment during extremely short time around 10-12 minutes. wLED based portable wire-device is an effective route to obtain bio-nanocomposition with anticancer and drug delivery potential as a pathway of targeted cancer therapy. Moreover, after applying multifunctional biocomposition on the tumor area this effective, eco-friendly, low cost and harmless for human health treatment takes only 10-12 minutes.