Browsing by Author "Haberal, A."

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Analysis of Bcl-2, Pten, P53 and Ki-67 Expressions in Endometrial Cancer Arising from Endometrial Polyp: Preliminary Results
(2017) Atasoy, L.; Kuscu, U. E.; Akilli, H.; Haberal, A.; Ayhan, A.; 0000-0002-0992-6980; 0000-0002-1486-7209; AEY-5060-2022; AAI-8792-2021; AAI-9331-2021; AAJ-5802-2021
Extended Surgery in Epithelial Ovarian Cancer Do Not Significantly Delay the Adjuvant Chemotherapy
(2016) Gunakan, E.; Kucukyildiz, I.; Akilli, H.; Dursun, P.; Haberal, A.; Ayhan, A.; 0000-0002-1486-7209; AAI-9331-2021; AAJ-5802-2021
The Prognostic Value of Lymph Node Ratio in Stage IIIC Cervical Cancer Patients Triaged To Primary Treatment By Radical Hysterectomy with Systematic Pelvic And Para-Aortic Lymphadenectomy
(2019) Aslan, K.; Meydanli, M. M.; Oz, M.; Tohma, Y. A.; Haberal, A.; Ayhan, A.; https://orcid.org/0000-0001-9418-4733; https://orcid.org/0000-0002-1486-7209; AAE-6482-2021; AAI-9331-2021; AAJ-5802-2021
Risk for Malignant and Borderline Ovarian Neoplasms Following Basic Preoperative Evaluation by Ultrasonography, Ca125 Level and Age
(2014) Karadag, Burak; Kocak, M.; Kayikcioglu, F.; Ercan, F.; Dilbaz, B.; Kose, M.F.; Haberal, A.; 25339052
Objective: To verify the basic preoperative evaluation in the discrimination between benign and malignant adnexal masses in our clinical practice. Materials and Methods: Data were collected on the records of 636 women with adnexal masses who had undergone surgery either by open or endoscopic approaches. Those with obvious signs of malignancy, any history of cancer, emergency surgeries without basic evaluation were excluded. The preoperative features by age, ultrasound and serum Ca125 level were compared with final histopathological diagnosis at the four departments of the institution. These are the general gynecology (Group 1:exploratory laparotomy), the gynecologic endoscopy (Group 2: laparoscopy and adnexectomy), the gynecological oncology (Group 3:staging laparotomy) and the gynecologic endocrinology and infertility (Group 4: laparoscopy and cystectomy). Results: There were simple and complex cyst rates of 22.3% and 77.2%, respectively. There were 86.3% benign, 4.1% (n:20) borderline ovarian tumor (BOT) and 6.4% (n:48) malignant lesions. There were 3 BOT and 9 ovarian cancers in Group 1 and one BOT and two ovarian cancer in the Group 2. During the surgery, 15 BOT (75%) and 37 ovarian cancer (77%) were detected in the Group 3, only one BOT was encountered in the Group 4. The risk of rate of unsuspected borderline or focally invasive ovarian cancer significantly increased by age, size, complex morphology and Ca125 (95% CI, OR=2.72, OR=6.60, OR=6.66 and OR=4.69, respectively). Conclusions: Basic preoperative evaluation by comprehensive ultrasound imaging combined with age and Ca125 level has proved highly accurate for prediction of unexpected malignancies. Neither novel markers nor new imaging techniques provide better information that allow clinicians to assess the feasibility of the planned surgery; consequently, the risk of inadvertent cyst rupture during laparoscopy may be significantly decreased in selected cases.
Surgical management and outcomes of metastatic tumors to the ovaries
(2019) Rahatli, S.; Akilli, H.; Haberal, N.; Altundag, O.; Haberal, A.; Ayhan, A.
Purpose of Investigation: Gynecologic and non-gynecologic tumors occasionally metastasize to the ovaries. Aim of this study was to describe the clinicopathologic characteristics and survival outcomes of patients with metastatic tumors to the ovaries. Materials and Methods: Between 2007-2017, 859 operations were performed in this center with initial diagnosis of ovarian mass. Seventy-five patients who had metastatic tumor to the ovaries in pathological examination were included the study. Results: Median overall survival of all patients was 26 +/- 5.9 months, three-year survival was 62%, and five-year survival was 37%. Patients who developed metachronous metastasis had better survival than patients who had synchronous metastasis (p = 0.05). Bilateral ovarian involvement was related with poor survival compared with unilateral involvement. Chemotherapy had beneficial effect on overall survival. Median survival in extensive surgery group was 30.9 months and it was better than minimal surgery group with 15.6 months, however it was not statistically significant (p= 0.973). Conclusion: The prognosis of the metastatic tumors to the ovaries is poor but achieving a complete resection and optimal debulking surgery may improve survival in some histologic subgroups.