Browsing by Author "Guvercin, Ayse Canan Yazici"

Now showing 1 - 3 of 3

Attitudes of Turkish university employees and their relatives towards whole body and organ donation
(2020) Oktem, Hale; Pelin, Can; Kurkcuoglu, Ayla; Yildirim, Rifat Vedat; Guvercin, Ayse Canan Yazici; 31676348
Background: Dissection of human anatomic specimens still keeps its importance in medical curriculum. Experiences of medical students in the anatomy laboratory and the time they spent there makes them feel as doctors at the beginning of their education and helps them to get used to the notion of death. Unfortunately, the number of human body donors available for medical research and education as well as organ transplantation is limited. Obtaining human anatomic specimens continues being a great problem especially in middle-east countries. Religious factors, socioeconomic status, education, marital status or age are probably the main factors those effect body donations. The aim of the present study is to evaluate the attitudes of Turkish university employees and their relatives towards whole body donation and organ donation. Methods: A total of 780 questionnaires taken from the participants were evaluated. All the participants were academic and administrative staff from four different universities based in Ankara, Eskisehir, Istanbul and Adana and their relatives. Participants were between the ages of 18-85. All the subjects were provided a questionnaire composed of 38 questions. Findings: 26.2% of the individuals declared that they could donate their body for medical education while 73.8% of them did not. In contrast, 69.1% of the participants were willing for being organ donors. Of the ones who had accepted to donate their organs, 64.5% refused to donate their bodies. Conclusion: The results of this study indicate that not only whole body donation, but also organ donation continue being a problem in Turkey. (C) 2019 Elsevier GmbH. All rights reserved.
Effects of Pesticides on Testes at Ultrastructural and Hormonal Levels
(2023) Unlukal, Nejat; Karabay, Gulten; Dagdeviren, Attila; Bayraktar, Nilufer; Guvercin, Ayse Canan Yazici; Tekindal, Mustafa Agah; 0000-0002-8107-4882
Aim: Endocrine disruptors damage the functions of hormones in the body by imitating or blocking them. They and their metabolites change hormone levels and functions in the body. Pesticides constitute a significant group of endocrine disruptors. It is known that Profenofos, and 4-chloro-2-methylphenoxyacetic acid (MCPA) have negative effects on male genital system. However, studies about the effect on ultrastructural size are limited. Therefore, it is intended to compare the effect of MCPA and Profenofos on the ultrastructural level of the testes. Material and Methods: There were three groups in the study (control, Profenofos, MCPA), each of which included ten fourteen-week-old male rats. Electron microscopy and biochemical investigation were performed on the excluded tissues of the testes. Results: In histopathologic investigations, spermatogenesis was healthy in the control group. Structural degenerations were observed on spermatogenic cells and Sertoli cells in the profenofos group. The gaps among spermatogenetic cells, cellular degeneration (i.e. structural damage) in the MCPA group was more obvious than in the Profenofos group. Considering the biochemical results, a significant decrease in testosterone level was observed in the animals receiving both profonefos and MCPA. Discussion: Profenofos and MCPA prevent the healthy continuation of spermatogenesis and therefore may cause infertility.
Uncoupling protein gene UCP1-3826A/G, UCP2 Ins/Del and UCP3-55C/T polymorphisms in obese Turkish children
(2020) Verdi, Hasibe; Kinik, Sibel Tulgar; Cebi, H. Pinar Baysan; Yalcin, Yaprak Yilmaz; Guvercin, Ayse Canan Yazici; Aydin, Beril; Tutunc, Neslihan Bascil; Atac, F. Belgin; 0000-0002-9141-9987; 0000-0002-9337-9106; 0000-0002-1816-3903; 33372430; AAH-2620-2021; ABB-4078-2020; ABG-5027-2020
Background. Mitochondrial uncoupling proteins (UCP) 1, 2 and 3 are members of the anion carrier protein family located in the inner mitochondrial membrane. There are various controversial reports on UCP genotypes and obesity in adults and children. This study aims to investigate the link between mostly studied UCP polymorphisms (UCP1-3826A/G, UCP2 Insertion/Deletion ans/Del) polymorphism of exon 8, and UCP3-55C/T Polymorphisms) and obesity in Turkish children. Furthermore, the relationships of UCP polymorphisms are also analyzed within the scope of metabolic parameters of obese children. Methods. Molecular screening of the UCP2, UCP2, and UCP3 gene polymorphisms was carried out in 189 children aged 6 to 18 years, 102 of who had exogenous obesity (54 girls) and 87 of whom were healthy controls (48 girls). In the obese group, fasting lipids, glucose and insulin levels were measured. In 60 obese children, an oral glucose tolerance test (OGTT) was performed with 0, 30, 60, 90 and 120 minutes of sampling for plasma glucose and insulin levels. Results. The frequency of UCP polymorphisms was similar in obese and non-obese children. In obese children, fasting lipids, glucose and insulin levels were not different among the UCP1, 2 and 3 genotypes. While no relationship was found between the UCP1 and 3 genotypes and glucose/insulin levels during OGTT, carriers of the Insertion allele with UCP2 Ins/Del polymorphism had significantly higher 30-minute insulin levels (p=0.018). Conclusions. Polymorphisms of the UCP1-3826A/G, UCP2 Ins/Del, and UCP3-55C/T are not associated with obesity and related pathologies in Turkish children. However, the presence of the Ins allele of the UCP2 gene has been found to have an unfavorable influence on early insulin excursion after glucose loading.