Browsing by Author "Gursu, Hazim A."

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Hypomagnesemia in Pediatric Heart Transplant Patients Treated with Tacrolimus
(2018) Erdogan, Ilkay; Gursu, Hazim A.; Varan, Birgul; Ozkan, Murat; Sezgin, Atilla; 0000-0001-6887-3033; 0000-0002-0707-2678; 0000-0002-6719-8563; 27364480; ABB-2220-2021; AHI-4502-2022; ABB-1767-2021
Objectives: We aimed to investigate the frequency of hypomagnesemia and urinary magnesium excretion in pediatric heart transplant recipients. Materials and Methods: In this study, 22 pediatric patients who underwent heart transplanted at a single center between March 2014 and April 2015 and who were treated with oral tacrolimus were analyzed prospectively. Serum magnesium, creatinine, and tacrolimus levels and total amount of urinary magnesium excretion were measured. Serum tacrolimus levels were measured 12 hours after the last dose of tacrolimus. Results: Our patient group included 11 boys (50%) and 11 girls (50%) with a mean age of 16.72 +/- 4.78 years. Serum tacrolimus levels were in the therapeutic range, with a mean of 1.48 +/- 0.13 ng/mL (range, 1.2-1.69 ng/mL), mean fractional magnesium excretion was 8.59 +/- 5.9% (range, 3%-22%), and 24-hour urinary magnesium excretion was 90.2 +/- 62.95 mg/d. Hypermagnesuria was assessed in 80% of patients. We found 24-hour urinary magnesium excretion to be higher than normal in 27% of patients. There was no association between serum tacrolimus levels and serum magnesium levels or urinary magnesium excretion. Conclusions: Serum magnesium levels should be periodically measured in pediatric heart transplant patients treated with tacrolimus.
Transposition of The Great Arteries and Cor Triatriatum: A Rare Combination
(2014) Gursu, Hazim A.; Varan, Birgul; Erdogan, Ilkay; Oktay, Ayla; https://orcid.org/0000-0002-0707-2678; https://orcid.org/0000-0002-6719-8563; https://orcid.org/0000-0001-6887-3033; 24018011; AHI-4502-2022; ABB-1767-2021; AAJ-2305-2021
In this case report, we present a 5-month-old girl diagnosed with a unique combination of transposition of the great arteries and cor triatriatum sinistra. A 1-day-old female patient presented to our hospital with cyanosis since the early neonatal period. We confirmed transposition of the great arteries by echocardiography. The patient underwent arterial switch operation on day 8 and was discharged on day 35. After 5 months of the operation, the patient had a lower respiratory tract infection and was unable to gain weight. Echocardiography revealed mild neopulmonary regurgitation, minimal neoaortic regurgitation, and pulmonary arterial hypertension. In addition, a fibrous membrane was also seen dividing the left atrium. The patient was diagnosed with cor triatriatum and underwent successful resection of the membrane.
Use of Oral Budesonide in The Management of Protein-Losing Enteropathy Due to Restrictive Cardiomyopathy
(2014) Gursu, Hazim A.; Varan, Birgul; Erdogan, Ilkay; https://orcid.org/0000-0002-0707-2678; https://orcid.org/0000-0002-6719-8563; https://orcid.org/0000-0001-6887-3033; 24029379; AHI-4502-2022; ABB-1767-2021; ABB-2220-2021
A 7-year-old male patient who had abdominal swelling and eyelid oedema was diagnosed with restrictive cardiomyopathy. His serum albumin level was 2.3 g/dl. Protein-losing enteropathy due to restrictive cardiomyopathy was diagnosed and oral budesonide was started. His serum albumin level began to rise and ascites and peripheric oedema disappeared. The patient underwent a successful cardiac transplantation and budesonide was stopped. After the heart transplantation, the albumin level decreased to 2.3 g/dl, and therefore it was restarted. When the serum albumin level increased, the budesonide dose was tapered and stopped in 1 month. Budesonide may be an effective drug in patients with protein-losing enteropathy due to heart failure.