Browsing by Author "Gundogan, Nimet Unay"

Now showing 1 - 9 of 9

Anticonvulsant Efficacy of Melatonin in an Experimental Model of Hyperthermic Febrile Seizures
(2015) Aydin, Leyla; Gundogan, Nimet Unay; Yazici, Canan; 0000-0002-3132-242X; 0000-0001-7784-9641; 26600370; AAS-6810-2021; ABC-5392-2020; AAK-4338-2021
Introduction: The anticonvulsant effects of melatonin (MT) have been demonstrated in several different experimental seizure models. Thus, the present study aimed to determine the anticonvulsant efficacy of MT, the optimum time for its administration prior to the induction of a seizure, and its effective dose in a rat model of hyperthermic febrile seizures (FSs). Methods: The present study included 72 male Sprague-Dawley rat pups divided into eight groups. The seizures were induced by keeping the rats in 45 degrees C water and the experiments were performed in two steps. In the first step, the control group was given a vehicle injection and the study groups were given a MT injection (150 mg/kg, intraperitoneal [i.p.]) at either 5, 10, or 15 min prior to the induction of the seizure to determine the anticonvulsant effects of MT and its optimum time of administration. In the second step, a vehicle injection and three different doses of MT (80, 100, and 150 mg/kg, i.p.) were administered 15 min prior to the induction of the seizure to determine the dose at which anticonvulsant effects could be achieved. The anticonvulsant effects were assessed based on the latency of the FSs. Results: In the first-step experiments, the FS latency of the control group was 143.4 +/- 15.3 s and the latencies of the groups given melatonin at either 5, 10, or 15 min prior to the seizure were 174.2 +/- 28.9, 177.4 +/- 21.0, and 193.7 +/- 17.6 s, respectively. Compared with the control group, the latencies for each of the study groups were significantly longer (p < 0.001), with the longest latency observed in the group given melatonin 15 min before the seizure. In the second-step experiments, the FS latencies of the groups that were given 80,100, and 150 mg/kg of MT 15 min before the seizure were 238.7 +/- 4.0, 240.0 +/- 0.0, and 193.7 +/- 17.6 s, respectively. These latencies were significantly longer than those of the control group (172.3 +/- 30.3 s, p < 0.001). Conclusion: The present study demonstrated that MT exerts anticonvulsant effects in a rat model of hyperthermic FSs and achieved its optimum efficacy at a dose of 80 mg/kg when administered 15 min prior to the induction of a seizure. (C) 2015 Elsevier B.V. All rights reserved.
Comparing the Short-term Effect of Drinking Caffeinated Coffee on Hand Skill Rate Performance Ability Due to its Hotness, Smelling and Caffeine Ingredient
(2016) Gundogan, Nimet Unay; Ilhan, A. Sebnem; Ogus, Ersin; Olsen, Anil Cenk; Gurcan, Buse; Ozer, Dogancan; Koru, Mine; Durak, Nazenin; Ugur, Duygu; 0000-0002-9877-421X; 0000-0001-7784-9641; AAJ-1058-2021; AAK-4338-2021
Comperation between Classic Annett Peg Moving Test with Computer Adopted Digital Annett Peg Moving Test
(2015) Gundogan, Nimet Unay; Yazici, Ayse Canan; 0000-0002-3132-242X; 0000-0001-7784-9641; AAS-6810-2021; AAK-4338-2021
Effect of age on the Relationship between Blood Pressure and Erythrocyte Indexes
(2015) Koctekin, Belkis Salman; Kurtoglu, Aysegul Ugur; Kurtoglu, Erdal; Gundogan, Nimet Unay; 0000-0001-7784-9641; AAK-4338-2021
Effects of Cognitive Load and State of Vigilance on Sympathetic Skin Response
(2022) Karimi, Nazli; Dolu, Nazan; Kiziltan, Erhan; Sirinoglu, Tugce; Gundogan, Nimet Unay
An Examination of the Relationship Between ABO Blood Groups and Hematological Parameters
(2017) Koctekin, Belkis; Kurtoglu, Aysegul; Tekindal, Agah; Kurtoglu, Erdal; Gundogan, Nimet Unay; 0000-0001-7784-9641; GVU-6849-2022; AAD-2048-2019; AAK-4338-2021
Examining Color Discrimination Ability and Depth Perception Relationship with Farnsworth Munsell 100 Hue Test, TNO Test and Titmus Test
(2017) Koctekin, Belkis; Coban, Deniz Turgut; Unal, Ayse Cengiz; Ozen, Mehmet; Tekindal, Agah; Altintas, Aysegul Kocak; Gundogan, Nimet Unay; https://orcid.org/0000-0001-7784-9641; AAK-4338-2021
Investigation of relationship between colour discrimination ability and stereoscopic acuity using Farnsworth Munsell 100 hue test and stereo tests
(2020) Koctekin, Belkis; Coban, Deniz Turgut; Ozen, Mehmet; Tekindal, Mustafa Agah; Unal, Ayse Cengiz; Altintas, Ayse Gul Kocak; Gundogan, Nimet Unay; 31712007
Objective: To evaluate the effect of colour discrimination ability on the stereoscopic acuity by comparing individuals having congenital colour vision deficiency (CCVD) with healthy individuals. Design: A comparative study. Participants: The study included 53 binocular males, of whom 26 (mean age, 36.04 +/- 9.30 years) were in the healthy group and 27 (mean age, 33.04 +/- 9.81 years) were in the CCVD group. Methods: The following tests were used: the Ishihara pseudo-isochromatic plate test for detecting CCVD, the Farnsworth Munsell 100 (FM100) hue test for colour discrimination ability, the TNO and Titmus stereo tests for stereoscopic acuity. Results: In the CCVD group, 20 males were deutan and 7 males were protan. According to the FM100 hue test, total error score (TES), blue/yellow (b/y) local error score (LES), and red/green LES were significantly lower in the healthy group (30.23 +/- 18.78, 15.15 +/- 10.38, and 13.88 +/- 11.93, respectively) than in the CCVD group (133.59 +/- 67.45, 41.15 +/- 22.03, and 89.15 +/- 52.16, respectively) (p < 0.01 for each). The stereo test scores revealed significantly higher stereoscopic acuity in the healthy group (43.85 +/- 33.92 arcsec for the TNO test and 40.00 +/- 0.00 arcsec for the Titmus test) than in the CCVD group (93.33 +/- 90.51 arcsec for TNO stereo test and 52.96 +/- 24.62 arcsec for the Titmus test) (p < 0.05 for each). The TNO test score was significantly and positively correlated with the TES (r = 0.390, p = 0.049) and b/y LES (r = 0.490, p = 0.011) in the healthy group. Conclusions: Colour discrimination ability affected stereoscopic acuity. Moreover, stereoscopic acuity increased with increasing colour discrimination ability, which could be originated from the b/y colour region.
Polyphasic Temporal Behavior of Finger-Tapping Performance: A Measure of Motor Skills and Fatigue
(2016) Aydin, Leyla; Kiziltan, Erhan; Gundogan, Nimet Unay; https://orcid.org/0000-0001-6029-3835; https://orcid.org/0000-0001-7784-9641; 25988674; ABC-5392-2020; AAD-6090-2021; AAK-4338-2021
Successive voluntary motor movement involves a number of physiological mechanisms and may reflect motor skill development and neuromuscular fatigue. In this study, the temporal behavior of finger tapping was investigated in relation to motor skills and fatigue by using a long-term computer-based test. The finger-tapping performances of 29 healthy male volunteers were analyzed using linear and nonlinear regression models established for inter-tapping interval. The results suggest that finger-tapping performance exhibits a polyphasic nature, and has several characteristic time points, which may be directly related to muscle dynamics and energy consumption. In conclusion, we believe that future studies evaluating the polyphasic nature of the maximal voluntary movement will lead to the definition of objective scales that can be used in the follow up of some neuromuscular diseases, as well as, the determination of motor skills, individual ability, and peripheral fatigue through the use of a low cost, easy-to-use computer-based finger-tapping test.