Browsing by Author "Gulec, Ayse Tulin"

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Comparison of 10 versus 20 sessions tap water iontophoresis efficacy in the treatment of palmoplantar hyperhidrosis
(2022) Vural, Ayse Tuncer; Ozcan, Deren; Gulec, Ayse Tulin; https://orcid.org/0000-0001-8770-5721; 34982502; AAQ-4123-2021
Background Tap water iontophoresis (TWI) is an effective treatment option for palmoplantar hyperhidrosis (HH). However, the optimal number and frequency of TWI sessions to control profuse sweating are unclear. Objective To compare the efficacy of 10 and 20 sessions of TWI in patients with palmoplantar HH and determine the adequate number of sessions to achieve a favorable clinical response. Methods Eighty patients treated with TWI for palmoplantar HH were included. The alteration in sweating intensity considering the mean value of gravimetric measurement and mean visual analog scale (VAS) scores after the 10th and 20th session of TWI were calculated. The difference between performing 10 and 20 sessions of TWI in providing improvement of HH was analyzed. We also conducted a telephone-based inquiry to determine the patients' outcome. Results The reduction in sweating intensity was significant both after the 10th (p < 0.001) and 20th (p < 0.001) sessions when compared with the basal level considering gravimetry and VAS. When the mean sweating intensity after the 10th and 20th sessions were compared, no difference was observed gravimetrically (p = 0.03); the difference between the mean score of VAS after the 10th and 20th sessions (p < 0.001) was significant. Eleven and nine patients not considering a maintenance or an alternative treatment had lower and same sweating intensity as compared with the baseline, respectively. Conclusion Ten TWI sessions within two weeks for managing palmoplantar HH are adequate to achieve a clinical response. However, the patients are more satisfied when they receive 20 sessions instead of 10 sessions of TWI.
Dermatoscopy Of Nodular/Plaque-Type Primary Cutaneous T- And B-Cell Lymphomas: A Retrospective Comparative Study With Pseudolymphomas And Tumoral/Inflammatory Mimickers By The International Dermoscopy Society
(2022) Errichetti, Enzo; Geller, Shamir; Zalaudek, Iris; Longo, Caterina; Kyrgidis, Athanassios; Akay, Bengu Nisa; Piccolo, Vincenzo; Myskowski, Patricia; Vitiello, Paola; Russo, Teresa; Argenziano, Giuseppe; Slawinska, Martyna; Sokolowska-Wojdylo, Malgorzata; Sobjanek, Michal; Toncic, Ruzica Jurakic; Rados, Jaka; Drvar, Daniela Ledic; Ceovic, Romana; Kaminska-Winciorek, Grazyna; Lanssens, Sven; Gulec, Ayse Tulin; Lobato-Berezo, Alejandro; Damiani, Giovanni; Maione, Vincenzo; Calzavara-Pinton, Piergiacomo; Sotiriou, Elena; Stinco, Giuseppe; Apalla, Zoe; Lallas, Aimilios; 34695527
Background: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available. Objective: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes. Methods: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Standardized assessments of the dermatoscopic images and comparative analyses were performed. Results: A total of 261 lesions were included (121 PCLs and 140 controls). Orange structureless areas were the strongest PCL dermatoscopic predictor on multivariate analysis compared with tumors and non infiltrative inflammatory dermatoses. On the other hand, a positive association was found between PCLs and either unfocused linear vessels with branches or focal white structureless areas compared with infiltrative inflammatory dermatoses, whereas white lines were predictive of PCLs over pseudolymphomas. Differences in the vascular pattern were also seen between B-and T-cell PCLs and among B-cell PCL subtypes. Limitations: Retrospective design and the lack of a dermatoscopic-pathologic correlation analysis. Conclusion: Nodular/plaque-type PCLs display dermatoscopic clues, which may partially vary according to histologic subtype and whose diagnostic relevance depends on the considered clinical differential diagnoses. ( J Am Acad Dermatol 2022;86:774-81.)
Kaposi Sarcoma in the Era of Rapamycin Remains a Therapeutic Challenge in Organ Transplant Recipients
(2018) Vural, Ayse Tuncer; Togral, Arzu Karatas; Gulec, Ayse Tulin; Haberal, Mehmet; 0000-0001-8770-5721; 0000-0002-3462-7632; 29527986; AAQ-4123-2021; AAJ-8097-2021
Solid-organ transplant recipients are at higher risk of developing Kaposi sarcoma, which is a multicentric vascular neoplasm of lymphatic endothelium-derived cells. Reducing doses of immunosuppressive drugs and switching from calcineurin inhibitors to the mammalian target of rapamycin inhibitor rapamycin have been suggested as an effective first-line treatment modality in most patients. Herein, we report a 64-year-old renal transplant recipient who developed multiple cutaneous and visceral Kaposi sarcoma lesions 2 months after transplant. The patient showed no improvement, with progression of the disease until month 15 of the suggested therapy of rapamycin.
Kaposi's Sarcoma Beneath A Cutaneous Horn
(2014) Yavuzekinci, Umran; Ozcan, Deren; Gulec, Ayse Tulin; https://orcid.org/0000-0002-7450-6886; 23331071; AAQ-6649-2021