Browsing by Author "Gokcan, Hale"

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    Fractalkine receptor polymorphism may not be associated with the development and clinical course of ulcerative colitis
    (2015) Gokcan, Hale; Yurtcu, Erkan; Selcuk, Haldun; Sahin, Feride I.; 26042517
    Fractalkine (CX3C), a chemokine expressed by epithelial cells within normal and inflamed colorectal mucosa, induces leukocyte adhesion and migration via fractalkine receptor. The aim of this study was to investigate two single nucleotide polymorphisms of the fractalkine receptor gene as a risk factor both for the development and clinical findings of ulcerative colitis. In this study, si patients with ulcerative colitis (UC) and 8o controls were recruited. Genotypes of fractalkine receptorc.743G>A (V249I) and c.839C>T (T280M) polymorphisms were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.Genotype distribution and allele frequencies of V249I and T280M were not statistically significantly different between UC and control groups (p>0.05). No statistically significant relationship was found between fractalkine receptor polymorphisms and clinical findings of UC. We observed no significant difference in fractalldne receptor polymorphism between patients and control group and no genotype-phenotype relation. Therefore, we concluded that fractalkine receptor polymorphisms may not contribute to the molecular pathogenesis of UC.
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    The Nutritional Risk Screening 2002 Tool For Detecting Malnutrition Risk in Hospitalised Patients: Perspective From A Developing Country
    (2014) Gokcan, Hale; Selcuk, Haldun; Tore, Emin; Gulseren, Pinar; Cambaz, Hatice; Saritas, Seniz; Ocal, Ruhsen; Basaran, Ozgur; Yilmaz, Ugur; Akin, Ebru; https://orcid.org/0000-0001-5663-0683; https://orcid.org/0000-0002-8445-6413; 25599788; AAR-8893-2020; AAJ-6976-2021; V-3553-2017
    Background/Aims: To verify the validity of the Nutritional Risk Screening (NRS) 2002 test in a Turkish population. Materials and Methods: We prospectively investigated 2566 patients at a tertiary referral hospital. Nutritional status was screened using NRS 2002, and the length of the stay (LOS) was the main outcome measure. Hospital stays >10 days were accepted as prolonged LOS. NRS scores >= 3 were accepted as indicating risk for malnutrition. Statistical analyses were performed to determine the independent risk factors for malnutrition risk and prolonged LOS. Results: The mean age of patients was 56.6 +/- 16.9 years. According to the NRS 2002, 964 patients (37.6%) were without risk, 1320 (51.4%) warranted surveillance and 282 (11%) were at high risk for malnutrition. Malnutrition rate was the highest in the intensive care unit (22.01%). Prolonged LOS was seen in 24.4% of patients. Intensive care unit stay [odds ratio (OR): 0.585; confidence interval (CI): 1.45-2.22; p<0.001] and an NRS score >= 3 (OR: 0.88; CI: 1.87-3.13; p<0.001) were independent risk factors for prolonged LOS. Conclusion: Improving healthcare outcomes while avoiding preventable healthcare costs is an important goal of healthcare provision in developing countries. NRS 2002 was predictive of LOS, and thus, of patient prognosis. Further community-based studies are warranted to assess the impact of NRS 2002 on reducing healthcare costs.
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    Predictors of Survival in Hepatocellular Carcinoma Patients
    (2015) Gokcan, Hale; Savas, Nurten; Oztuna, Derya; Moray, Gokhan; Boyvat, Fatih; Haberal, Mehmet; 0000-0003-2498-7287; 0000-0002-3462-7632; 26438974; AAE-1041-2021; AAJ-8097-2021; F-4230-2011
    Background: Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide, with an incidence equal to the death rate. Material/Methods: We aimed to detect the prognostic factors for HCC patients. We retrospectively analyzed 12 years data of 115 patients who have biopsy-proven HCC. Clinical and demographic characteristics of patients with treatment modalities, survival rates, and prognostic factors were analyzed. Results: There were 93 male patients, and the mean age was 63.5 +/- 11.8 years. Most patients had cirrhosis due to hepatitis virus infection. Median follow-up time was 17 months (1 month-9.5 years) after the diagnosis of HCC. The nodule was single in 43 (37.4%) patients, there were 2-3 nodules in 30 (26.1%), and >3 or diffuse nodules in 42 (36.5%) patients. Distribution of treatment modalities was as follows: 23 (20%) patients had liver transplantation, 15 (13%) had HCC resection, 12 patients (10.4%) had radiofrequency ablation (RFA), 26 patients (22.6%) had transarterial chemoembolization (TACE), 2 (1.7%) had alcohol ablation, and 37 patients (32.2%) had no treatment. Tumor sizes of 9 patients (39.1%) in the transplanted group exceeded the Milan criteria. Mean survival was 72 +/- 6.9, 78.8 +/- 12.5, 19.5 +/- 2.8, 20.6 +/- 4.2, 16.0 +/- 5.9 months in those that received transplantation, resection, RFA, TACE, and no treatment, respectively (p<0.001). Survival was significantly poorer in patients >63 years old (p=0.001), with serum albumin level <= 3.4 g/dL (p=0.01), and with diffuse HCC (p<0.001). Conclusions: Survival was significantly better in patients who underwent liver transplantation or surgical resection. Tumor number, age, and serum albumin level were the most important prognostic factors related to overall survival.
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    Preliminary Results Of The Effectiveness And Safety Of Tenofovir Alefenamide Fumarate Prophylaxis In HBV-Infected Individuals, Who Received Chemo/Immunosuppressive Therapy
    (2022) Gunduz, Feyza; Durak, Serdar; Unsal, Yasemin; Demir, Mehmet; Ellik, Zeynep Melekoglu; Yildirim, Abdullah Emre; Mehdiyev, Shahin; Adanir, Haydar; Demirtas, Coskun Ozer; Ucbilek, Enver; Balaban, Yasemin; Koc, Elif Sitre; Etik, Digdem Ozer; Gokcen, Pinar; Ari, Derya; Gokcan, Hale; Yapali, Suna; Ekmen, Nergis; Arslan, Mehmet; Kayhan, Meral Akdogan; Ozdil, Kamil; Sezgin, Orhan; Boyacioglu, Sedat; Simsek, Halis; Tozun, Nurdan; Dincer, Dinc; Idilman, Ramazan
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    Real Life Efficacy And Tolerability Of Tenofovir Alafenamde Fumarate In Liver Transplant Recipients: A Multicenter Study
    (2022) Gokcan, Hale; Yapali, Suna; Harputluoglu, Murat; Ellik, Zeynep Melekog. Lu; Gokcen, Pinar; Adanir, Haydar; Cosar, Arif Mansur; Durak, Serdar; Ari, Derya; Mehdiyev, Shahin; Koc, Elif Sitre; Guzelbulut, Fatih; Alkim, Huseyin; Ekmen, Nergis; Yildirim, Abdullah Emre; Unsal, Yasemin; Teker, Tufan; Etik, Digdem Ozer; Vatansever, Sezgin; Balaban, Hatice Yasemin; Ozdil, Kamil; Arslan, Mehmet; Kayhan, Meral Akdogan; Gunduz, Feyza; Kiyici, Murat; Boyacioglu, Sedat; Simsek, Halis; Tozun, Nurdan; Dincer, Dinc; Idilman, Ramazan