Browsing by Author "Erdem, Saban Remzi"

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Assessment of Mental Workload and Academic Motivation in Medical Students
(2016) Atalay, Kumru Didem; Can, Gulin Feryal; Erdem, Saban Remzi; Muderrisoglu, Ibrahim Haldun; https://orcid.org/0000-0002-7537-2170; 27183939; AAJ-2370-2021
Objectives: To investigate the level of correlation and direction of linearity between academic motivation and subjective workload. Method: The study was conducted at Baskent University School of Medicine, Ankara, Turkey, from December 2013 to February 2014, and comprised Phase 5 Phase 6 medical students. Subjective workload level was determined by using National Aeronautics and Space Administration Task Load Index scale that was adapted to Turkish. Academic motivation values were obtained with the help of Academic Motivation Scale university form. SPSS 17 was used for statistical analysis. Results: Of the total 105 subjects, 65(62%) students were in Phase 5 and 40(38%) were in Phase 6. Of the Phase 5 students, 18(27.7%) were boys and 47(72.3%) were girls, while of the Phase 6 students, 16(40%) were boys and 24(60%) were girls. There were significant differences in Phase 5 and Phase 6 students for mental effort (p= 0.00) and physical effort (p= 0.00). The highest correlation in Phase 5 was between mental effort and intrinsic motivation (r= 0.343). For Phase 6, highest correlation was between effort and amotivation (r= -0.375). Conclusion: Subjective workload affected academic motivation in medical students.
Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats
(2022) Emre-Aydingoz, Selda; Lux, Karl Michael; Efe, Oguzhan Ekin; Topcu, Deniz Ilhan; Erdem, Saban Remzi; 0000-0001-7823-7620; 0000-0002-3243-7843; 0000-0002-1219-6368; 35993621; ABA-4291-2020; W-7908-2019; E-3717-2019
The effect of rosuvastatin (Ros) on cognitive function and anxiety-like behaviour in ovariectomized rats were evaluated. Eighteen female Wistar rats (218-310g, 6-8 months old) were allocated into sham (n = 6), ovariectomy (Ovx, n = 6) or Ovx + Ros (up to eighth week n = 6, then n = 4) groups. Ros was administered at 20 mg/kg/day by oral gavage for 12 weeks. Behavioural tests were performed at 4, 8 and 12 weeks following Ovx. At 12weeks, Ovx group had significantly longer escape latency than the sham group at the first day of the four-day training period of the Morris Water Maze test (p < .01). In the Elevated Plus Maze test, Ovx group spent significantly more time in the closed arms than the sham group (p < .01), and this anxiety-like behavioural effect of Ovx was prevented by 12-weeks Ros treatment (p < .05). In conclusion, Ros prevents memory deficit and anxiety-like behaviour in the ovariectomized rats, a model for human surgical menopause.
Effects of Platelet-Rich Fibrin Membrane on Sciatic Nerve Regeneration
(2018) Bayram, Burak; Akdeniz, Sidika Sinem; Diker, Nurettin; Helvacioglu, Fatma; Erdem, Saban Remzi; 0000-0002-7825-1083; 0000-0002-6026-0045; 0000-0002-7537-2170; 29381631; AAS-4519-2020; AAH-8887-2021; AAJ-2370-2021
Alternative treatment approaches to improve the regeneration capacity of damaged peripheral nerves are currently under investigation. The objective of the present study was to evaluate the effects of platelet-rich fibrin (PRF) membrane after sciatic nerve crush injury in rabbits by histomorphometric and electromyographic analysis. The left sciatic nerves of 20 male Vienna rabbits were clamped for 30seconds to induce crush injuries. Animals were randomly divided into 2 groups: PRF and control. For each animal in the PRF group, a PRF membrane was wrapped around the injured part of the sciatic nerve to form a tube. No additional treatment was performed in the control group. After a 12-week healing period, tissue samples from the injured nerve region were harvested and the g-ratio of axons, axon density, and impulse transmission changes were evaluated. Analysis revealed that axon density differences were not statistically significant between groups (P=0.139). The rate of nerve fibers with optimum g-ratio was significantly lower in the PRF group than in the control group (P=0.02). Conduction velocity differences between groups were not statistically significant. Although PRF application has previously shown positive regeneration effects on maxillofacial tissues, local PRF membrane application in tube form did not show any histomorphometric or functional improvement in peripheral nerve crush injury recovery.
The Protective Effect of Metformin Against the Noise-Induced Hearing Loss
(2018) Kesici, Gulin Gokcen; Ocal, Fatma Ceyda Akin; Gurgen, Seren Gulsen; Erdem, Saban Remzi; Ogus, Ersin; Erbek, Hatice Seyra; Ozluoglu, Levent Naci; 0000-0003-0409-6225; 0000-0002-7537-2170; 0000-0002-9877-421X; 0000-0002-2150-0237; 30306316; AAT-2326-2021; AAJ-2370-2021; AAJ-1058-2021; AAI-8020-2021
ObjectiveTo test the protective effect of metformin against noise-induced hearing loss.Methods24 rats were included in the study. The first group was exposed to noise only, the second group took metformin, the third group was exposed to noise and took metformin, and the fourth group was neither exposed to noise nor took metformin as control group. After measurement of baseline DPOAE and ABR of rats, the metformin group and the metformin+noise group received 300mg/kg/day metformin via gavage for 10days. On the 11th day, group 1 and group 3 were exposured to white noise at 105dB SPL for 15h. After noise exposure, DPOAE and ABR measurements of all rats were repeated on days 1st, 7th, and 21st. At the end of the study, all animals were sacrificed and cochlear tissues were separated for immunohistochemical assessments.ResultsABR threshold values and DPAOE measurements of groups 1 and 3 were deteriorated on the 1st day after noise, while deterioration in group 1 continued on 7th and 21st days, but normalized on 7th day in group 3. After immune staining, a significant immunoreaction was observed in the noise group, while the reaction in the noise+metformin group was close to the control group.ConclusionMetformin has a protective effect on noise-induced hearing loss in rats. As a conclusion, it is determined that metformin protects from permanent threshold shift in rats. It can be considered a good alternative for protecting noise-induced hearing loss.