Browsing by Author "Emre, Sinan"

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Are optic discs with large physiological cups really healthy?
(2017) Ulusoy, Mahmut Oguz; Emre, Sinan; 28254119; T-5643-2019
Evaluation of the acute effect of haemodialysis on retina and optic nerve with optical coherence tomography
(2016) Emre, Sinan; Ozturkeri, Anil; Ulusoy, Mahmut Oguz; Cankurtaran, Cem; 28003781; T-5643-2019
Purpose: The primary objective of haemodialysis (HD) was to correct the composition and volume of body fluids. The aim of this study was to evaluate the acute effect of HD on mean arterial pressure changes and on retina and optic nerve with optical coherence tomography (OCT). Methods: Fifty-three eyes of 28 patients were enrolled in this study. The patients' retinal and RNFL thicknesses were measured by OCT and mean arterial pressure alterations were recorded before and immediately after HD session. Results: The results show that while there was a reduction at central foveal thickness and ganglion cell layer thickness, central sub-field and RNFL thickness were increased with HD session. But none of them were statistically significant (p = 0.320, p = 0.792, p = 0.744, p = 0.390). The mean arterial pressure of the patients decreased significantly (p < 0.05) but it was not correlated with retinal and RNFL values. Conclusion: The changes in retinal and RNFL findings were not significant. But these alterations may effect the long term follow-up of the patients with retinal and optic nerve disease. Therefore it is important to pay attention HD session time for these patients' measurements.
Impact of Valsalva Maneuver on Central Choroid, Central Macula, and Disk Fiber Layer Thickness Among High Myopic and Hyperopic Patients
(2017) Kurultay Ersan, Isil; Emre, Sinan; 0000-0001-5616-4256; 27445069; AAL-4632-2021; T-5643-2019
Purpose: To evaluate the alterations in mean central choroidal, central macular, and disk retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) during Valsalva maneuver among patients with high refractive errors. Methods: A total of 60 high myopic (>=-6.0 D) and 50 high hyperopic (>= + 3.0 D) eyes of 58 patients aged 1965 years with visual acuity of 20/20 and without any ophthalmologic or systemic diseases were evaluated by OCT before and after the Valsalva maneuver. The choroidal thickness was measured with enhanced depth imaging OCT method. Central macular thickness, disk RNFL thickness, and axial length were also assessed. Results: Mean choroidal thickness increased significantly from 275.0 +/- 27.2 mu m at rest to 279.8 +/- 31.6 mu m after Valsalva maneuver in high myopic patients, and from 308.2 +/- 27.3 mu m to 313.6 +/- 28.5 mu m in high hyperopic patients (p<0.01 for each). A significant negative correlation of the choroidal thickness was noted with axial length (r = -0.509, p<0.01) and age (r = -0.224, p = 0.01) in the overall study population. Mean central macular thickness was 242.9 +/- 44.4 mu m and 254.0 +/- 22.8 mu m, while mean disk RNFL thickness was 81.6 +/- 12.4 mu m and 98.4 +/- 13.3 mu m in high myopic and hyperopic patients, respectively. Valsalva maneuver was not associated with significant change in central macular or disk RNFL thickness. Conclusions: Significant association of Valsalva maneuver with an increase in choroidal thickness was noted among patients with high degree of myopia and hyperopia. Our findings emphasize the likelihood of increase in choroidal volume due to venous distension to be responsible for the increase observed in choroidal thickness after Valsalva maneuver.
Importance of Optical Coherence Tomography Angiography in Differential Diagnosis of NMOSD and RRMS
(2019) Tiftikcioglu, B. Irem; Emre, Sinan; Idiman, Fethi; Idiman, Egemen
Investigation of Corneal Biomechanics at Moderate to High Refractive Errors
(2018) Inceoglu, Nehir; Emre, Sinan; Ulusoy, Mahmut Oguz; 28540493; T-5643-2019
Corneal hysteresis (CH) and corneal resistance factor (CRF) are corneal biomechanical parameters which were measured by ocular response analyzer (ORA). Aim of this study was to define the CH and CRF in high myopic and hyperopic patients and compare the results with emmetropic control group. A total of 193 eyes of 100 healthy volunteers were included. Study groups were high myopic patients (n = 27) with spherical refractive errors (SRE) of greater than -5.00D, high hyperopic patients (n = 20) with SRE of greater than +3.00D and controls (n = 53) with SRE between +/- 1.00D. All subjects underwent IOP and corneal biomechanical evaluation with the ORA. Also Goldmann applanation tonometry (GAT), central corneal thickness (CCT), corneal curvature and axial length measurements were taken. Mean age of groups was 30.7 +/- 6.9, 29.1 +/- 7.7, 28.9 +/- 5.6 years (p > 0.05). Among study groups except CRF and CCT, all parameters were significantly different between study groups. CH was lowest in the high myopic group and highest in the high hyperopia. In all groups, there were significant correlations between CH and CRF, CCT, SRE, SE (spherical equivalent), AL (axial length) and between CRF and CCT. GAT and IOPg (Goldmann-correlated intraocular pressure) measurements were significantly correlated with CCT (p < 0.05). One of the major findings was as the CH approaches 11.2 mmHg, IOPcc (corneal-compensated intraocular pressure) and IOPg get close to each other. The results revealed that CRF is not affected by refractive errors and IOPcc is not affected by any other ocular parameter. The difference between IOPcc and IOPg was greatest in myopic group, and IOP (intraocular pressure) measurement in these patients deserves high suspicion.
Optical Coherence Tomography Angiography (OCTA) In Differential Diagnosis Of Aquaporin-4 Antibody Seronegative NMOSD And Multiple Sclerosis
(2022) Tiftikcioglu, Bedile Irem; Emre, Sinan; Idiman, Fethi; Idiman, Egemen; 35030370
Backround: Optic neuritis(ON) is a common feature of both relapsing-remitting multiple sclerosis(RRMS) and neuromyelitis optica spectrum disorders(NMOSD). It is crucial to early differentiate these two diseases, as they differ in pathophysiology and treatment.& nbsp;Objective: To compare NMOSD and RRMS patients using optical coherence tomography(OCT) and OCT angiography(OCTA) to assess retinal microvascular network differences.& nbsp;Methods: Fourteen RRMS (28 eyes) and 9 NMOSD patients(18 eyes), and 11 controls were enrolled. Seropositivity for aquaporin-4 antibody (anti-AQP4 Abs) was 44.4%. Peripapillary and macular retinal nerve fiber layer (RNFL) thickness, superficial peripapillary and macular vessel density(VD), area, perimeter and circularity of foveal avascular zone(FAZ) were analyzed.& nbsp;Results: OCTA showed reduction in peripapillary and macular VD and FAZ size in NMOSD+ON compared to RRMS+ON and controls (p = 0.001, p < 0.001 and p = 0.010, p < 0.001 respectively). Peripapillary VD was similar in RRMS +ON and controls. Peripapillary VD in monophasic seronegative NMOSD+ON eyes was significantly lower than monophasic RRMS+ON eyes (p = 0.030), which was no different from controls. FAZ area was smaller in unaffected eyes in NMOSD than RRMS and controls.& nbsp;Conclusions: Both OCT and OCTA revealed considerable differences between RRMS and NMOSD patients, providing promising results in favor of clinical utility of OCTA in differential diagnosis of ON, particularly in antiAQP4 antibody negative patients. OCTA might be a useful biomarker in differentiating NMOSD from MS.
Optical coherence tomography angiography findings in Behcet patients
(2019) Emre, Sinan; Guven-Yilmaz, Suzan; Ulusoy, Mahmut Oguz; Ates, Halil; 30710254
PurposeRetinal vasculitis and vein occlusions are common causes of serious visual loss in Behcet's disease. We aimed to evaluate the optical coherence tomography angiography (OCTA) findings of Behcet uveitis (BU) patients.MethodsWe evaluated 32 eyes of 16 patients with BU and 30 eyes of 15 healthy controls. Superficial capillary plexus (SCP) and deeper capillary plexuses (DCP) were evaluated using OCTA RTVue XR AVANTI.ResultsOn SCP, nonperfusion/hypoperfusion areas (NPA) were seen in 10 eyes, perifoveal capillary arcade disruption (PCAD) was seen in 10 eyes, capillary network disorganization (CND) was seen in 7 eyes and intraretinal cystoid spaces (ICS) were seen in 2 eyes. On DCP, NPA were seen in 13 eyes, PCAD was seen in 11 eyes, CND was seen in 7 eyes and ICS were seen in 4 eyes.ConclusionWe showed that DCP were affected more than SCP in these patients. In addition, capillary vessel density of BU group was significantly lower than control group.