Browsing by Author "Duffas, Jean Pierre"

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    Tamoxifen Therapy in Kidney-Transplant Patients Presenting With Severe Encapsulating Peritoneal Sclerosis After Treatment for Acute Humoral Rejection
    (Başkent Üniversitesi, 2009-09) Mohamed, Abdellatif Ould; Rostaing, Lionel; Duffas, Jean Pierre; Esposito, Laure; Nogier, Marie-Béatrice; Kamar, Nassim
    Objectives: Encapsulating peritoneal sclerosis is a rare but serious complication in patients undergoing peritoneal dialysis. Its mortality rate is approximately 30%, despite treatment with total parenteral nutrition, surgery, tamoxifen, or immunosuppressants. Materials and Methods: Of 991 kidney transplants performed at our institution over 9 years, 50 patients were treated for chronic peritoneal dialysis at the time of transplant. Results: Two cases of encapsulating, peritoneal sclerosis occurred in patients receiving pretransplant peritoneal dialysis. Both had received intensive posttransplant treatment for acute humoral rejection. Encapsulating peritoneal sclerosis occurred at 3 months and 4 months after the transplant. Both presented with intestinal pain and gut obstruction. They were given total parenteral nutrition plus tamoxifen (20 mg/d) for 3 months. Outcomes were favorable for 1, though there was no improvement for the second patient, who was then also given sirolimus. He died later from multiorgan failure secondary to digestive-related sepsis, and encapsulating, peritoneal, sclerosis-related symptoms. Conclusions: When encapsulating, peritoneal sclerosis occurs after kidney transplant, tamoxifen therapy could be implemented.