Browsing by Author "Doruk, Pinar"

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    Autosomal Dominant Osteopetrosis Type II
    (2015) Ozkan, Aslihan Kusvuran; Doruk, Pinar; Adam, Mehmet; Celik, Zerrin Yilmaz; Leblebici, Berrin; 0000-0002-3528-3712; 0000-0002-6241-268X; 0000-0001-9158-220X; 24898439; AAA-8043-2021; AAM-3220-2021; A-1229-2015; ABD-2882-2021
    Osteopetrosis is a rare genetic disorder caused by osteoclast failure. Dominant negative mutations of the ClCN7 gene cause the so-called, autosomal dominant osteopetrosis type II, which represents the most frequent and heterogeneous form of osteopetrosis, ranging from asymptomatic to intermediate-severe, thus suggesting additional genetic and environmental determinants affecting penetrance. Here, we present a case a 46 year-old woman complained low back pain for 15 years. The patient lacked any history of direct trauma and her pain was radiating to her left leg, increasing with physical activity, she had no pain at nights. The patient was diagnosed with autosomal dominant osteopetrosis on the basis of the presence of typical radiological appearance. Were present a case report of osteopetrosis type II (an autosomal dominantly inherited disease) as a cause for low back pain without any familial penetrance of the disease.
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    Fibromyalgia Syndrome in Turkish Hemodialysis Patients
    (2016) Leblebici, Berrin; Ozelsancak, Ruya; Yilmaz, Emine Ece; Doruk, Pinar; https://orcid.org/0000-0002-6241-268X; https://orcid.org/0000-0002-0788-8319; https://orcid.org/0000-0002-8602-6038; https://orcid.org/0000-0002-3528-3712; 26198740; AAM-3220-2021; AAD-5716-2021; AAA-8043-2021
    The aim of our study was to evaluate the frequency of fibromyalgia syndrome (FMS) in hemodialysis (HD) patients and to assess whether this syndrome is associated with gender, age, duration of HD, or various laboratory parameters. This study was composed of 221 chronic HD patients (99 females and 122 males), and we recorded each participant's age, gender, causes of kidney failure, HD duration, education level, and symptoms related to FMS, which was diagnosed according to the 2010 American College of Rheumatology criteria. We documented the laboratory parameters for all patients. In addition, patients with FMS filled out the Fibromyalgia Impact Questionnaire. Twenty-two patients met the diagnostic criteria for FMS (9%), and there were no statistically significant differences related to age, gender, or HD duration between FMS and non-FMS groups (P>0.05). In addition, the education levels were lower in patients diagnosed with FMS (P<0.05), and there were statistically significant differences related to sleep disturbance, fatigue, and cognitive symptoms between the two groups (P<0.05) as well. However, their laboratory parameters were similar (P>0.05). There was a higher prevalence of FMS in HD patients than in the general population. Sleep disturbances, fatigue, education level, and cognitive symptoms were associated with FMS, but there was no correlation between the laboratory parameters and this condition.