Browsing by Author "Demirci, Bahar Gurlek"
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Item Ambulatory Blood Pressure Measurement As A Prognostic Tool in Renal Transplant Recipients(2016) Tutal, Emre; Sezer, Siren; Bal, Zeynep; Demirci, Bahar Gurlek; Moray, Gokhan; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAZ-5795-2021; AAE-1041-2021; AAJ-8554-2021; AAJ-8097-2021Item The Association Between Beta2-Microglobulin Levels, Inflammation and Nutritional Status in Chronic Hemodialysis and Kidney Transplant Patients(2017) Tutal, Emre; Demirci, Bahar Gurlek; UyaniK, Saliha; Ekenci, Damla; Sezer, SirenItem The Associations Between Sodium Intake and Kidney Damage with Echocardiographic Parameters in Renal Transplant Recipients(2017) Tutal, Emre; Demirci, Bahar Gurlek; Sezer, Siren; Uyanik, Saliha; Ozdemir, Ozlem; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAJ-8554-2021; AAJ-8097-2021Item The Associations Between Sodium Intake and Kidney Damage with Echocardiographic Parameters in Renal Transplant Recipients(2017) Tutal, Emre; Demirci, Bahar Gurlek; Sezer, Siren; Uyanik, Saliha; Ozdemir, Ozlem; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAJ-8554-2021; AAJ-8097-2021Item Bone Loss Is Associated with Graft Dysfunction at the Time of First Year of Kidney Transplantation: A Cross-Sectional Study(2014) Sezer, Siren; Demirci, Bahar Gurlek; Tutal, Emre; Guliyev, Orhan; Sayin, Cihat Burak; Acar, Fatma Nurhan Ozdemir; Haberal, Mehmet; https://orcid.org/0000-0002-7326-8388; https://orcid.org/0000-0001-8287-6572; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-3462-7632; J-3707-2015; AAK-1697-2021; AAJ-8097-2021Item Dietary Fiber Intake: Its Relation With Glycation End Products and Arterial Stiffness in End-Stage Renal Disease Patients(2019) Demirci, Bahar Gurlek; Tutal, Emre; Eminsoy, Irem O.; Kulah, Eyup; Sezer, Siren; 30314838; AAB-3881-2021Objective: We aimed to analyze the relationship between the effect of total dietary fiber intake on C-reactive protein (CRP) and on oxidative stress parameters such as serum advanced glycation end products (AGEs), superoxide dysmutase (SOD), malondialdehyde, and arterial stiffness by pulse wave velocity (PWv) in maintanace hemodialysis (MHD) patients. Methods: Among 650 MHD patients, 128 were selected according to inclusion criteria. The dietary survey was performed with a 3-day dietary history. Dietary fiber level was adjusted for total energy intake by the residual method. Patients were stratified by quartiles of adjusted dietary fiber (ADF) level as group 1 (n = 32) (ADF: <8.86 g/day), group 2 (n = 35) (ADF: 8.86-12.50 g/day), group 3 (n = 31) (ADF: 12.51-15.90 g/day), and group 4 (n = 30) (ADF: >= 15.91 g/day). Monthly assessed biochemical parameters including serum hemoglobin, albumin, CRP, calcium, phosphorus, and lipid profile levels were recorded. Serum AGEs, SOD, and malondialdehyde levels were determined by ELISA method. The PWv was determined from pressure tracing over carotid and femoral arteries. Results: Patients in group 3 and 4 had significantly lower CRP and AGE than those in group 1 and 2. Mean serum SOD level and PWv were significantly higher in group 4. In regression analysis, ADF intake was the unique predictor for both AGE (r(2) = 0.164, P = 0.017) and CRP levels (r(2) = 0.238, P = 0.01). Conclusion: Present data show that dietary fiber intake is independently correlated with inflammation and oxidative stress. In addition, decreased fiber intake results in impaired arterial stiffness. Thus, adequate fiber intake could prevent cardiovascular events and inflammatory processes in patients undergoing MHD. (C) 2018 by the National Kidney Foundation, Inc. All rights reserved.Item Fgf-23, Ngal and Endostatin: The Predictors of Allograft Function and Arterial Stiffness in Renal Transplant Recipients(2017) Sezer, Siren; Demirci, Bahar Gurlek; Uyanik, Saliha; Erdogan, Meltem Kaynar; Tutal, Emre; Ozdemir, Ozlem; Orazbayev, Gani; Haberal, Mehmet; https://orcid.org/0000-0002-3462-7632; AAJ-8097-2021Item FGF23, NGAL, and Endostatin: the Predictors of Allograft Function in Renal Transplant Recipients(2018) Demirci, Bahar Gurlek; Sezer, Siren; Yildirim, Saliha Uyanik; Erdogan, Meltem Kaynar; Tutal, Emre; Ozdemir, Ozlem; Orazbayev, Gani; Haberal, Mehmet; 0000-0002-3462-7632; 29528011; AAJ-8097-2021Objectives: Increased circulating levels of fibroblast growth factor 23, neutrophil gelatinase-associated lipocalin, and endostatin are independent risk factors for cardiovascular disease. Here, we evaluated correlations among these parameters and graft dysfunction and their relation with arterial stiffness. Materials and Methods: This prospective study included 73 maintenance kidney transplant patients with stable allograft function who had received the transplant at least 36 months previously. We calculated the estimated glomerular filtration rate (eGFR). Pulse-wave velocity was determined. Serum levels of fibroblast growth factor 23, neutrophil gelatinase-associated lipocalin, and endostatin were measured by enzyme-linked immunosorbent assay. Results: Demographic characteristics and pulse-wave velocity values were similar in groups 1 and 2 (GFR < 60 and > 60 mL/min, respectively). Mean levels of fibroblast growth factor 23 (P = .036), neutrophil gelatinase-associated lipocalin (P = .018), and endostatin were significantly higher in group 1. Fibroblast growth factor 23 was negatively correlated with eGFR (r = -0.267, P = .023) and positively correlated with neutrophil gelatinase-associated lipocalin (r = 0.258, P = .036) and endostatin (r = 0.321, P = .006). Serum endostatin levels were positively correlated with pulse-wave velocity (r = 0.276, P = .019). In linear regression analysis, eGFR was detected as the unique predictor of neutrophil gelatinase-associated lipocalin (P = .001). In addition, each 1 mL/min decrease in eGFR resulted in a 0.281 pg/mL increase in fibroblast growth factor 23 (P = .023) and a 0.04 ng/mL increase in neutrophil gelatinase-associated lipocalin (P = .007); each 1 cm/s increase in pulse-wave velocity resulted in a 3648.7 U/L increase of endostatin (P = .019). Conclusions: All 3 parameters were associated with loss of graft function in kidney transplant recipients. Moreover, endostatin can be used as an independent predictor for cardiovascular morbidity in this population.Item Hand Grip Strength Is Associated with Serum Testosterone and Albumin Levels in Male Kidney Transplant Recipients(2017) Sezer, Siren; Demirci, Bahar Gurlek; Tutal, Emre; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAJ-8554-2021; AAJ-8097-2021Item Hand-Grip Strength Is Associated With Serum Testosterone and Albumin Levels in Male Kidney Transplant Recipients(2018) Demirci, Bahar Gurlek; Sezer, Siren; Tutal, Emre; Colak, Turan; Uyanik, Saliha; Haberal, Mehmet; 0000-0002-8372-7840; 0000-0002-3462-7632; 29527997; AAJ-8554-2021; AAJ-8097-2021Objectives: In kidney transplant recipients, reduced muscle mass and hand-grip strength are associated with impaired nutritional status. Serum testosterone is highly associated with muscle strength in the general population. Here, we aimed to determine the associations among serum testosterone, hand-grip strength, and nutritional and inflammatory parameters, as well as graft function. Materials and Methods: Our study included 144 stable male kidney transplant recipients from our renal transplant outpatient clinic. All patients were evaluated for clinical parameters (age, duration of hemodialysis, and posttransplant time), biochemical parameters (calcium, phosphorus, parathyroid hormone, C-reactive protein, albumin, creatinine), and serum testosterone levels. Body composition was analyzed with the bioimpedance spectroscopy analysis technique using a body composition monitor that estimates body mass index and percent fat. Hand-grip strength was analyzed by using a dynamometer (ProHealthcareProducts.com, Park City, UT, USA). We calculated estimated glomerular filtration rate using the Modification of Diet in Renal Disease-4 equation. Results: Demographic characteristics, duration of dialysis before transplant, biochemical parameters, and estimated glomerular filtration rates were similar among study patients. Mean (standard deviation) serum testosterone was 588.0 (55.5) ng/dL, mean body mass index was 26.8 (0.6) kg/m(2), and mean hand-grip strength was 42.2 (1.7) mm(2). Serum testosterone levels were positively correlated with hand-grip strength (r = 0.445; P = .033) and serum albumin (r = 0.399; P = .05) and negatively correlated with serum C-reactive protein (r = -0.454;P= .05) and age. In linear multiple regression analysis, serum albumin (P= .033) and testosterone levels (P = .038) were shown to be predictors of hand-grip strength. However, we could not show a significant correlation between graft function and testosterone. Conclusions: Serum testosterone level is correlated with hand-grip strength and C-reactive protein and albumin levels, which may indicate that testosterone affects nutritional status and inflammation in male renal transplant recipients.Item Hyperproteinuria As A Cardiovasculary Risk Factor in Renal Transplant Recipients(2014) Guliyev, Orhan; Uyar, Mehtap Erkmen; Sezer, Siren; Bal, Zeynep; Colak, Turan; Demirci, Bahar Gurlek; Acar, Nurhan Ozdemir; Haberal, Mehmet; https://orcid.org/0000-0002-7326-8388; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; JYQ-2550-2024; AAZ-5795-2021; AAJ-8554-2021; AAJ-8097-2021Item Low 25-Hydroxy Vitamin D, High Fibroblast Growth Factor 23 and Arterial Stiffness in Hemodialysis Patients with Chronic Kidney Disease: "The Chicken or Egg Phenomenon"(2014) Bal, Zeynep; Uyar, Mehtap Erkmen; Gokustun, Dilek; Demirci, Bahar Gurlek; Tutal, Emre; Sezer, Siren; https://orcid.org/0000-0002-7326-8388; AAZ-5795-2021; JYQ-2550-2024Item Morning Blood Pressure Surge In Renal Transplant Recipients: Its Relation To Graft Function And Arterial Stiffness(2022) Demirci, Bahar Gurlek; Afsar, Baris; Tutal, Emre; Colak, Turan; 35704743Background: When the blood pressure rises before awakening in the morning, it is called as morning blood pressure pulse (MBPS). MBPS is considered to be an independent risk factor for cardiovascular disease. The aim of this study was to investigate the associations between MBPS, graft function, arterial stiffness and echocardiographic indices in renal transplant recipients. Methods: Among 600 renal transplant recipients, 122 patients who had a history of hypertension and were taking at least one anti hypertensive medication were enrolled in the study. Arterial stiffness was measured by carotid-femoral pulse wave velocity (PWv), and echocardiographic indices were assessed. 24 h ambulatory blood pressure was monitored for all patients. MBPS was calculated by subtracting morning systolic blood pressure from minimal asleep systolic blood pressure. Results: Mean morning, day time and asleep systolic blood pressure values were 171.2 +/- 23.9, 137.9 +/- 18.1, and 131.7 +/- 18.9, respectively. Nondipper hypertension status was observed in 93 patients. Mean MBPS was 35.6 +/- 19.5 mm Hg, means PWv was 6.5 +/- 2.0 m/s. Patients with MBPS >= 35 mm Hg, had significantly lower eGFR and higher proteinuria, PWv. higher left atrium volume and LVMI. In regression analysis, day time systolic blood pressure, asleep systolic blood pressure, morning blood pressure surge, nondipper status and left ventricular mass index were detected as the predictors of graft function. Conclusions: Increased morning blood pressure surge is associated with graft dysfunction, increased arterial stiffness and LVMI that contribute to cardiovascular mortality and morbidity in renal transplant recipients.Item Myostatin Induced Muscle Atrophy and Its Relation with Igf1 Signaling in Renal Transplant Recipients(2018) Kal, Oznur; Demirci, Bahar Gurlek; Uyanik, Saliha; Orazbayev, Gani; Tutal, Emre; Sezer, Siren; https://orcid.org/0000-0002-7751-4961; AAJ-7586-2021Item Obesity and Loss of Kidney Function: Two Complications to Face for Older Living Kidney Donors(2017) Kaya, Demet Firat; Sayin, Burak; Saglam, Hatice; Demirci, Bahar Gurlek; Colak, Turan; https://orcid.org/0000-0001-8287-6572; https://orcid.org/0000-0002-8372-7840; 28260454; J-3707-2015; AAJ-8554-2021Objectives: Although living kidney donors have a minimal lifetime risk of developing end-stage renal disease, long-term complications and physiologic and psychologic sequelae resulting from donation remain unclear because of lack of optimum follow-up after transplant. Here, we evaluated renal function, complications, and physical and mental performance of living kidney donors. Materials and Methods: We evaluated 147 patients who donated living kidneys between 1981 and 2012 at Baskent University Hospital. We collected data on donor age, sex, body mass index, smoking status, hypertension before and after nephrectomy, proteinuria, estimated glomerular filtration rate according to the Modification of Diet in Renal Disease formula, and duration after donation. All donors answered the Medical Outcomes Study short-form general health survey; results were evaluated according to answers to 11 questions totaling 22 points. Results: Body mass index of donors showed that 31 (21.1%) were in normal range, 66 (44.9%) had mild obesity (body mass index of 26-30 kg/m(2)), and 30 (34%) had moderate to high obesity (body mass index > 30 kg/m(2)). Results from the general health survey showed that 117 donors (80%) had no loss, 13 (9%) had mild loss, 12 (8%) had moderate loss, and 5 (3%) had high loss of ability. When we compared estimated glomerular filtration rates according to donor age, donors who were 18 to 34 years had a mean estimated glomerular filtration rate of 113.5 +/- 40, donors 35 to 49 years had a mean rate of 95.01 +/- 23.4, donors 50 to 64 years had a mean rate of 87.43 +/- 25.4, and donors older than 65 years had a mean rate of 63.76 +/- 11.35 mL/min/1.73 m(2), revealing a statistically significant loss of kidney function with aging (P = .001). Conclusions: Careful evaluation of kidney donors before and after donation is essential for the most common risk factors, such as obesity, and for loss of kidney function, especially in older donors.Item Outcomes of Nutritional Support Modalities in Maintenance Hemodialysis Patients(2016) Demirci, Bahar Gurlek; Bal, Zeynep; Erkmen, Mehtap; Sezer, Siren; AAZ-5795-2021Item Oxidative Stress in Maintenance Hemodialysis Patients(2014) Uyar, Mehtap Erkmen; Bal, Zeynep; Bayraktar, Nilufer; Demirci, Bahar Gurlek; Sayin, Burak; Sezer, Siren; https://orcid.org/0000-0002-7886-3688; https://orcid.org/0000-0001-8287-6572; https://orcid.org/0000-0002-7326-8388; IAO-2608-2023; AAZ-5795-2021; Y-8758-2018; J-3707-2015; JYQ-2550-2024Item Positive Incomes of Nutritional Support Modalities in Terms of Inflammation and Cardiovascular Status(2016) Demirci, Bahar Gurlek; Tutal, Emre; Bal, Zeynep; Sezer, Siren; AAZ-5795-2021Item QUALITY OF SLEEP, QUALITY OF LIFE AND FATIGUE: ARE THEY RELATED WITH SERUMVITAMIN D LEVEL?(2015) Demirci, Bahar Gurlek; Sayin, Cihat Burak; Tutal, Emre; Bal, Zeynep; Sezer, SirenItem Relationship Between Malnutrition Inflammation Score, Overhydration and Arterial Stiffness in Hemodialysis Patients(2016) Bal, Zeynep; Tutal, Emre; Ozelsancak, Ruya; Genctoy, Gultekin; Demirci, Bahar Gurlek; Sezer, Siren; https://orcid.org/0000-0002-0788-8319; https://orcid.org/0000-0002-5145-2280; AAZ-5795-2021; AAD-5716-2021; AAJ-5551-2021