Browsing by Author "Demir, Ali"

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Comparison of Low and High Grade Glioma Maps
(2015) Cotur, Yasin; Ozkan, Mehmed; Demir, Ali; Turnaoglu, Hale; Agildere, Ahmet M.; Alkan, Ozlem; Ulug, Aziz M.; 0000-0002-0781-0036; 0000-0003-4223-7017; AAK-8242-2021; AAB-5802-2020
It is crucial to detect the locations of brain tumors for the diagnosis. The aim of this study was the generation and comparison of the high and low-grade probabilistic brain tumor maps to present the tumor observance frequencies in the brain tissue. T1-weighted, pre-operated data from 162 brain tumor patients are examined during the study. Although most of high-grade tumors are located around the superior and right lateral regions of sub-ventricular zone, low-grade gliomas are mostly observed in the posterior part of the sub-ventricular zone. Moreover, since all types of tumors are gathered close to the sub-ventricular zone, our results support the theory proposing that there is a relation between gliomas and sub-ventricular zone, which is the origin of glial cells.
Comparison of the Canadian CT head rule and the new orleans criteria in patients with minor head injury
(2014) Kavalci, Cemil; Aksel, Gokhan; Salt, Omer; Yilmaz, M. Serkan; Demir, Ali; Kavalci, Gulsum; Ozel, Betul Akbuga; Altinbilek, Ertugrul; Durdu, Tamer; Yel, Cihat; Durukan, Polat; Isik, Bahattin
Aim: The aim of the study was to compare the New Orleans Criteria and the New Orleans Criteria according to their diagnostic performance in patients with mild head injury. Methods: The study was designed and conducted prospectively after obtaining ethics committee approval. Data was collected prospectively for patients presenting to the ED with Minor Head Injury. After clinical assessment, a standard CT scan of the head was performed in patients having at least one of the risk factors stated in one of the two clinical decision rules. Patients with positive traumatic head injury according to BT results defined as Group 1 and those who had no intracranial injury defined as Group 2. Statistical analysis was performed with SPSS 11.00 for Windows. ROC analyze was performed to determine the effectiveness of detecting intracranial injury with both decision rules. p < 0.05 was considered statistically significant. Results: 175 patients enrolled the study. Male to female ratio was 1.5. The mean age of the patients was 45 +/- 21,3 in group 1 and 49 +/- 20,6 in group 2. The most common mechanism of trauma was falling. The sensitivity and specificity of CCHR were respectively 76.4% and 41.7%, whereas sensitivity and specificity of NOC were 88.2% and 6.9%. Conclusion: The CCHR has higher specificity, PPV and NPV for important clinical outcomes than does the NOC.
Evaluation of The Effect of Lipid Emulsıon Therapy on The Rat Model in Organophosphate Intoxication and Tissue Pathologies
(2014) Celikel, Elif; Arslan, Engin Deniz; Yilmaz, Fevzi; Turhan, Turan; Unal, Muge Tecder; Turhan, Turan; Turhan, Nesrin; Kavalci, Cemil; Karakilic, M. Evvah; Altunkaynak, Hande Ozge; Unal, Muge Tecder; Demir, Ali; AAH-5151-2020
Introduction and objective: Organophosphates are frequently used for agricultural spraying in an uncontrolled manner in our country. Humans are usually inadvertently exposed to these chemicals via respiratory, transdermal, or tranconjunctival routes whereas they may also be used for suicidal purposes: Having a high morbidity and mortality, this intoxication causes a high emergency department admission rate (1). Previous studies on lipid therapy in cardiac arrest associated with intoxication of lipophilic agents such as antidepressants, anticonvulsants, antihypertensives, and local anesthetics have reported a 55% increase in survival with these therapies (2). We also studied lipid emulsion therapy (LET) in poisoning with organophosphates that are lipophilic. Materials and method: This study used 30 male Wistar-albino rats of 12 months of age weighting 288 to 428 gr. The animals were randomly grouped into 5 groups: Group 1 Was the control group; Group 2 organophosphate+serum physiologic (SF) group; Group 3 organophosphate+LET group; Group 4 arganophosphate + Atropin(A)+ Pralidoxime (PAM) group; and Group 5 organophosphate+LET+A+PAM group. After an 8-hour clinical observation period the rats were sacrificed and Wad pseudocholitiesterase, cholesterol; and triglyceride levels were studied. Renal, hepatic, splenic, and cerebral tissues were sampled to be examined under light microscope. Results : There were significant differences between the groups with respect to cholesterol, triglyceride, but not pseudocholine-sterase level Dizziness was the first observed clinical symptom, followed by hindleg paralysis, foreleg paralysis, and general paralysis. After general paralysis salivation was usually observed together with gasping breathing. Rats with the above clinical course were sacrificed. The clinical picture progressed rapidly after foreleg paralysis. The toxic clinical course was observed in 100% of rats in Group 2 (organophosphate + SF) and Group 3 (Organophosphate +LET) and its mortality rate was high. No significant difference was observed between both groups with respect to time to symptom onset. This may be interpreted as that LET treatment alone was not effective. Conclusion: In the present study we did not observe any beneficial effect of LE treatment alone on mortality of organophosphate intoxication. According to our results, however, it may be beneficial when used in conjunction to Classical therapy. Considering its relatively low side effect profile and pros and cons, we believe that it can be used as a supportive therapy in organophosphate poisoning.
Routinely Evaluated Clinical Assays and Laboratory Tests [Real Test] And Fibrosis Stages of Chronic Hepatitis B and C
(2014) Bugdaci, Mehmet Sait; Korkmaz, Huseyin; Demir, Ali; Biyik, Murat; Temel, Tuncer; Gokturk, Huseyin Savas; Ozakyol, Aysegul; Hatemi, Ibrahim; Baysal, Birol; Karaca, Cetin; Senturk, Hakan; 25417616
Background/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45 +/- 13/years [emale/male (F/M)=47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52 +/- 10.3/years [F/M=61/39%]. When the cut-off value of the REAL TEST formula"[(age x pT x AST)/(PLT/1000)]/100" in patients with hepatitis B was determined to be >= 1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)=0.852, 95% CI: 0.82-0.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be >= 1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC: 0.95, 95% CI: 0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.
The value of Serum BNP for diagnosis of intracranial injury in minor head trauma
(2014) Demir, Ali; Kavalci, Cemil; Yilmaz, Muhittin Serkan; Yilmaz, Fevzi; Durdu, Tamer; Ceyhan, Mehmet Ali; Alagoz, Fatih; Yel, Cihat
Objective: Head injury is the main cause of death among individuals younger than 45 years old. Cranial Computerized tomography (CT) is commonly used for diagnosis of head injury. Brain Natriuretic Peptide (BNP) is a peptide originally isolated from brain ventricles. The main aim of this study is to investigate BNP as an indicator of head injury among patients presenting to emergency department (ED) with minor head trauma. Methods: This was a prospective study conducted at the emergency department of the Numune Training and Research Hospital. A total of 162 patients who presented to the ED with minor head injury were enrolled. The patients were categorized into 2 groups as the cranial CT-negative and positive groups. The normality of the data was tested using One Sample Kolmogorov Smirnov test. Mann-Whitney U test was used to compare 2 independent groups while the Kruskal-Wallis test was utilized for comparison of more than 2 groups. A p-value of <0.05 was considered to be significant. Results: Ninety-six (59.3%) patients were male and 66 (40.7%) were female. The cranial CT-negative group had a median BNP level of 14.5 pg/ml while the cranial CT-positive group had a median BNP level of 13 pg/ml. There was no statistically significant difference between these two groups for serum BNP levels (p > 0.05). Conclusion: This study suggested that serum BNP level wasn't used in defined of intracranial injury.