Browsing by Author "Delyon, Julie"

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    Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study
    (2019) Delyon, Julie; Rabate, Clementine; Euvrard, Sylvie; Harwood, Catherine A.; Proby, Charlotte; Gulec, Tulin; Seckin, Deniz; Del Marmol, Veronique; Bouwes-Bavinck, Jan Nico; Ferrandiz-Pulido, Carla; Ocampo, Maria Andrea; Barete, Stephane; Legendre, Christophe; Frances, Camille; Porcher, Raphael; Lebbe, Celeste; 30902727
    Background: Systemic therapeutic management of post-transplant Kaposi sarcoma (KS) is mainly based on 3 axes: reduction of immunosuppression, conversion to mammalian target of rapamycin (mTOR) inhibitors, chemotherapy, or a combination of these. Objective: To obtain an overview of clinical strategies about the current treatment of KS. Methods: We conducted a multicenter retrospective cohort study including 145 solid organ transplant recipients diagnosed with KS between 1985 and 2011 to collect data regarding first-line treatment and response at 6 months. Results: Overall, 95%, 28%, and 16% of patients had reduction of immunosuppression, conversion to mTOR inhibitor, and chemotherapy, respectively. Patients treated with chemotherapy or mTOR inhibitor conversion were more likely to have visceral KS. At 6 months, 83% of patients had response, including 40% complete responses. Limitations: The retrospective design of the study. Conclusion: Currently available therapeutic options seem to be effective to control KS in most patients. Tapering down the immunosuppressive regimen remains the cornerstone of KS management.