Browsing by Author "Delibas, Ali"

Now showing 1 - 5 of 5

Could Plasma Based Therapies Still Be Considered in Selected Cases with Atypical Hemolytic Uremic Syndrome?
(2021) Ozlu, Sare Gulfem; Gulhan, Bora; Aydog, Ozlem; Atayar, Emine; Delibas, Ali; Parmaksiz, Gonul; Ozdogan, Elif Bahat; Comak, Elif; Tasdemir, Mehmet; Acar, Banu; Ozcakar, Zeynep Birsin; Topaloglu, Rezan; Soylemezoglu, Oguz; Ozaltin, Fatih; 35023648
Background. Atypical hemolytic uremic syndrome (aHUS) occurs due to defective regulation of the alternative complement pathway (ACP) on vascular endothelial cells. Plasma based therapy (PT) was the mainstay of the treatment for aHUS for many years until the introduction of therapies targeting blockage of the complement system. The aim of this study was to evaluate patients with aHUS who had been treated with plasma based therapies alone. Methods. The outcomes of seven genetically confirmed aHUS patients (2 girls, 5 males) were evaluated by means of clinical presentation, response to plasma therapy, course of the disease during the follow-up period and last status. Results. The median age of the patients at admission was 6.7 years (IQR 0.7-7.8). Three patients received plasma exchange therapy and the other four patients were treated with plasma infusions. One patient was lost to follow-up after one year; the median duration of follow-up for other patients was 3.7 years (IQR 2.7-6.5). During the follow up, two patients from our historical records when complement blocking therapies had not been in clinical use yet in Turkey, underwent kidney transplantation. One transplant patient experienced an acute rejection episode without graft loss. The remaining five patients had a glomerular filtration rate of more than 90 ml/min./1.73 m(2) at the last visit. Conclusion. Although we had a relatively small patient population, our findings indicate that PT might still be considered in selected patients particularly in countries where complement blocking therapies are difficult to reach due to their unavailability or costs that are not covered by the health care systems.
Education Status of Pediatric Dialysis Patients in Turkey
(2018) Delibas, Ali; Ekim, Mesiha; Yildirim, Zeynep Yuruk; Dusunsel, Ruhan; Kara, Ashhan; Noyan, Aytul; Bayazit, Aysun Karabay; Conkar, Secil; Yazicioglu, Burcu Ozer; Serdaroglu, Erkin; Aksoy, Gulsah Kaya; Akinci, Nurver; Yilmaz, Dilek; Bek, Kenan; Ertan, Pelin; Gurgoze, Metin Kaya; Kabasakal, Caner; Doven, Serra Surmeli; Turkkan, Ozde Nisa; Gunay, Neslihan; Parmaksiz, Gonul; Melek, Engin; Erdogan, Semra; Ezgu, Sevcan Azime Bakkaloglu; Sever, Lale; https://orcid.org/0000-0003-2373-1837; AAD-5713-2021; AAM-2935-2021
Evaluation of non-infectious complications of peritoneal dialysis in children: a multicenter study
(2020) Aksoy, Gulsah Kaya; Ekim, Mesiha; Bakkaloglu, Sevcan A.; Coskun, Seda; Delibas, Ali; Conkar, Secil; Yilmaz, Dilek; Kara, Aslihan; Saygili, Seha K.; Buyukkaragoz, Bahar; Yildirim, Zeynep Y.; Comak, Elif; Gurgoze, Metin K.; Sever, Lale; Noyan, Aytul; Bayazit, Aysun K.; Dusunsel, Ruhan; 32728843; AAD-5713-2021
Background Peritoneal dialysis (PD) is the most common kidney replacement therapy in children. Complications associated with PD affect treatment success and sustainability. The aim of this study was to investigate the frequency of PD-related noninfectious complications and the predisposing factors. Methods Retrospective data from 11 centers in Turkey between 1998 and 2018 was collected. Non-infectious complications of peritoneal dialysis (NICPD), except metabolic ones, in pediatric patients with regular follow-up of at least 3 months were evaluated. Results A total of 275 patients were included. The median age at onset of PD and median duration of PD were 9.1 (IQR, 2.5-13.2) and 7.6 (IQR, 2.8-11.9) years, respectively. A total of 159 (57.8%) patients encountered 302 NICPD within the observation period of 862 patient-years. The most common NIPCD was catheter dysfunction (n = 71, 23.5%). At least one catheter revision was performed in 77 patients (28.0%). Longer PD duration and presence of swan neck tunnel were associated with the development of NICPD (OR 1.191; 95% CI 1.079-1.315, p = 0.001 and OR 1.580; 95% CI 0.660-0.883, p = 0.048, respectively). Peritoneal dialysis was discontinued in 145 patients; 46 of whom (16.7%) switched to hemodialysis. The frequency of patients who were transferred to hemodialysis due to NICPD was 15.2%. Conclusions Peritoneal dialysis-related non-infectious complications may lead to discontinuation of therapy. Presence of swan neck tunnel and long duration of PD increased the rate of NICPD. Careful monitoring of patients is necessary to ensure that PD treatment can be maintained safely.
Evaluation Of Patients With Primary Hyperoxaluria Type 1: A Multicenter Study
(2018) Bakkaloglu, Sevcan A.; Buyykkaragoz, Bahar; Saygili, Seha; Comak, Elif; Yildirim, Zeynep Y.; Akinci, Nurver; Bayazit, Aysun Karabay; Tufan, Asli Kavaz; Akman, Sema; Yilmaz, Alev; Dursun, Ismail; Noyan, Aytul; Agbas, Ayse; Serdaroglu, Erkin; Delibas, Ali; Elmaci, Ahmet Midhat; Tasdemir, Mehmet; Sever, Lale; AAD-5713-2021
Transplantation in Fsgs: A Multicentric Study From Turkey
(2018) Koyun, Mustafa; Akman, Sema; Comak, Elif; Bakkaloglu, Sevcan; Parmaksiz, Gonul; Alparslan, Caner; Poyrazoglu, Hakan; Canpolat, Nur; Bayazit, Aysun Karabay; Delibas, Ali; Yildiz, Nurdan; Ozcelik, Gul; Ozdogan, Elif Bahat; https://orcid.org/0000-0003-2373-1837; AAM-2935-2021