Browsing by Author "Colak, Turan"

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Acute Renal Injury in Liver Transplant Patients and Its Effect on Patient Survival
(2014) Kirnap, Mahir; Colak, Turan; Baskin, Esra; Akdur, Aydincan; Moray, Gokhan; Arslan, Gulnaz; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; 24635816; AAH-9198-2019; AAJ-8554-2021; B-5785-2018; AAA-3068-2021; AAE-1041-2021; AAJ-8097-2021
Objectives: Acute renal injury is a common complication in liver transplant patients. Acute kidney injury is due to nephrotoxic drugs used after liver transplant, infections, and hemorrhage. Though it is generally reversible, it has effects on grafts and patients survival. In this retrospective observational study carried out at a single center, the effects of acute renal disease on liver recipient's survival were investigated. Materials and Methods: Liver transplant recipients of live-donor and deceased-donor transplants between January 2002 and May 2013 were included in this study; there were 310 liver transplant patients (mean age, 28 y; age range, 6 mo-62 y; 165 males, 145 females). The acute kidney disease diagnosis and staging was based on the nephrology department evaluation and daily serum creatinine levels. Patients with acute kidney injury before undergoing liver transplant and those undergoing a transplant for the second time were excluded. Kidney functions were evaluated by the nephrology department 1 week, 3 months, and 1 year after the liver transplant. Results: Acute kidney disease rates in these patients were 5%, 8%, and 12%. Four patients developed chronic kidney failure during follow-up. The mortality rate was higher (18%) in acute renal failure patients compared with those that did not have acute renal failure. The mortality rate was 11% in patients without acute renal failure. Conclusions: Acute renal injury is common after liver transplant and has an effect on mortality.
Ambulatory Blood Pressure Measurement As A Prognostic Tool in Renal Transplant Recipients
(2016) Tutal, Emre; Sezer, Siren; Bal, Zeynep; Demirci, Bahar Gurlek; Moray, Gokhan; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAZ-5795-2021; AAE-1041-2021; AAJ-8554-2021; AAJ-8097-2021
ANGIOTENSIN RECEPTOR BLOCKERS PROVIDE BETTER GLOMERULAR FILTRATION RATES THAN ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN KIDNEY TRANSPLANT RECIPIENTS WITH PROTEINURIA
(2020) Etlik, Zeynep Melekoglu; Sayin, Burak; Erdogmus, Siyar; Colak, Turan; Akdur, Aydincan; Haberal, Mehmet A.
The Associations Between Sodium Intake and Kidney Damage with Echocardiographic Parameters in Renal Transplant Recipients
(2017) Tutal, Emre; Demirci, Bahar Gurlek; Sezer, Siren; Uyanik, Saliha; Ozdemir, Ozlem; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAJ-8554-2021; AAJ-8097-2021
The Associations Between Sodium Intake and Kidney Damage with Echocardiographic Parameters in Renal Transplant Recipients
(2017) Tutal, Emre; Demirci, Bahar Gurlek; Sezer, Siren; Uyanik, Saliha; Ozdemir, Ozlem; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAJ-8554-2021; AAJ-8097-2021
Bone Mineral Densitometry and Effecting Factors in Patients with Succesful Renal Transplantation
(2014) Canoz, Mujdat Batur; Yavuz, Demet Dolu; Altunoglu, Alpaslan; Yavuz, Rahman; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-4082-6320; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; ABG-9980-2021; AAJ-8554-2021; AAJ-8097-2021
DO THE BLOOD GROUPS AND HLA TYPES HAVE A ROLE IN END STAGE CHRONIC RENAL FAILURE PATHOGENESIS? A COMPARATIVE RETROSPECTIVE SINGLE-CENTER STUDY
(2020) Musabak, Ugur; Turgut, Didem; Sayin, Cihad Burak; Colak, Turan; Karakaya, Emre; Haberal, Mehmet A.
Early Conversion to mTOR Inhibitors Prevents Kidney Function Better Than Late Conversion
(2018) Atay, Gokhan; Sayin, Burak; Colak, Turan; Acar, Nurhan Ozdemir; Sezer, Siren; Haberal, Mehmet; 0000-0001-8287-6572; 0000-0002-8372-7840; 0000-0002-3462-7632; J-3707-2015; AAJ-8554-2021; AAJ-8097-2021
Effects of Renal Transplantation and Hemodialysis on Patient's General Health Perception and Oral Health-Related Quality of Life: A Single-Center Cross-Sectional Study
(2020) Oduncuoglu, Bahar Fusun; Alaaddinoglu, Emine Elif; Colak, Turan; Akdur, Aydincan; Haberal, Mehmet; 0000-0002-8726-3369; 0000-0002-8372-7840; 0000-0002-3462-7632; 0000-0003-0647-9481; 32113695; AAA-3068-2021; AAJ-8554-2021; AAJ-8097-2021; AAQ-4792-2020
Background. Patients with end-stage renal disease have a lower quality of life compared to the general population. Oral health-related quality of life (OHRQoL) is of particular interest as good oral health could influence general health. This study aimed to compare dental and periodontal health status, OHRQoL, and general health perception of renal transplant (TX) and hemodialysis patients (HD) with that of healthy controls. Methods. The study included 64 TX, 63 HD, and 61 healthy patients. TX patients were also grouped according to the time elapsed after transplantation and currently use of immunosuppressive agents. The numbers of decayed, missing, and filled teeth were recorded as DMFT, and periodontal health status was evaluated. Patients' general health perceptions and OHRQoL were assessed using Short Form-36, Oral Health Impact Profile-14, and OHRQoL-United Kingdom questionnaires. Results. The HD groups presented significantly higher DMFT scores and periodontal scores than TX and control groups. OHRQoL-United Kingdom total scores of TX and HD groups were lower than controls (P < .05). Oral Health Impact Profile-14 total scores revealed that HD groups' OHRQoL was significantly lower than TX and control groups (P < .05). Perceptions of general health of TX patients were higher than in the HD group. Conclusions. Renal transplantation has shown to increase quality of life and OHRQoL compared to hemodialysis therapy. Neither the immunosuppressive agent nor the time elapsed after transplantation were observed to be significant factors affecting OHRQoL.
EVALUATION OF DENTAL AND PERIODONTAL HEALTH OF RENAL TRANSPLANT AND HEMODIALYSIS PATIENTS
(2020) Oduncuoglu, Bahar; Gulsahi, Ayse; Arhun, Neslihan; Colak, Turan; Haberal, Mehmet A.
Evaluation of Dynapenia and Sarcopenia and Their Associations With Serum Insulin-Like Growth Factor-1 Levels in Renal Transplant Recipients
(2022) Yildirim, Saliha; Colak, Turan; Bayraktar, Nilufer; Sezer, Siren; https://orcid.org/0000-0002-2693-1167; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-7886-3688; https://orcid.org/0000-0002-7326-8388; 34716090; AAJ-8554-2021; Y-8758-2018
Objectives: Dynapenia and sarcopenia are related to increased morbidity and mortality in the general population. Chronic kidney disease (CKD) causes sarcopenia and dynapenia with different mechanisms. The aim of this study is to compare the muscle parameters in renal transplant recipients to CKD patients and patients without kidney disease and assess their associations with serum insulin-like growth factor-1 (IGF-1) levels. Method: In total, 120 renal transplant recipients (mean age: 40.4 +/- 10.5 years), 60 CKD patients (mean age: 41.9 +/- 11.4 years), and 60 control subjects with normal kidney function (mean age: 38.8 +/- 9.9 years) were enrolled. Body mass index, hand grip strength, bioelectrical impedance analysis, 6-minute walking test, and serum IGF-1 level were measured and compared between groups. Muscle parameters were evaluated according to The Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project criteria. Results: IGF-1 levels were highest in the renal transplantation group and lowest in the control group (P = .029). In total, 12.5% of patients in the renal transplantation group (13.3% overweight, 20% obese), 11.6% in the CKD group, and 1.6% in the control group had dynapenia (P = .015). In addition, 8.3% of patients in the CKD group, 3.3% in the renal transplantation group (50% overweight), and none of the patients in the control group had sarcopenia (P = .054). In multivariate analyses, muscle strength was associated with IGF-1 levels in renal transplant recipients (beta = 2.314, t = 3.456, P = .001). Conclusions: Serum IGF-1 is closely associated with muscle strength in renal transplant recipients. The negative effects of CKD on muscle system cannot be completely resolved with renal transplantation. Sarcopenic obesity and dynapenic obesity need special attention and therefore body mass index cannot be used as the only parameter to evaluate frailty in renal transplant recipients. (C) 2021 by the National Kidney Foundation, Inc. All rights reserved.
Hand Grip Strength Is Associated with Serum Testosterone and Albumin Levels in Male Kidney Transplant Recipients
(2017) Sezer, Siren; Demirci, Bahar Gurlek; Tutal, Emre; Colak, Turan; Haberal, Mehmet; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; AAJ-8554-2021; AAJ-8097-2021
Hand-Grip Strength Is Associated With Serum Testosterone and Albumin Levels in Male Kidney Transplant Recipients
(2018) Demirci, Bahar Gurlek; Sezer, Siren; Tutal, Emre; Colak, Turan; Uyanik, Saliha; Haberal, Mehmet; 0000-0002-8372-7840; 0000-0002-3462-7632; 29527997; AAJ-8554-2021; AAJ-8097-2021
Objectives: In kidney transplant recipients, reduced muscle mass and hand-grip strength are associated with impaired nutritional status. Serum testosterone is highly associated with muscle strength in the general population. Here, we aimed to determine the associations among serum testosterone, hand-grip strength, and nutritional and inflammatory parameters, as well as graft function. Materials and Methods: Our study included 144 stable male kidney transplant recipients from our renal transplant outpatient clinic. All patients were evaluated for clinical parameters (age, duration of hemodialysis, and posttransplant time), biochemical parameters (calcium, phosphorus, parathyroid hormone, C-reactive protein, albumin, creatinine), and serum testosterone levels. Body composition was analyzed with the bioimpedance spectroscopy analysis technique using a body composition monitor that estimates body mass index and percent fat. Hand-grip strength was analyzed by using a dynamometer (ProHealthcareProducts.com, Park City, UT, USA). We calculated estimated glomerular filtration rate using the Modification of Diet in Renal Disease-4 equation. Results: Demographic characteristics, duration of dialysis before transplant, biochemical parameters, and estimated glomerular filtration rates were similar among study patients. Mean (standard deviation) serum testosterone was 588.0 (55.5) ng/dL, mean body mass index was 26.8 (0.6) kg/m(2), and mean hand-grip strength was 42.2 (1.7) mm(2). Serum testosterone levels were positively correlated with hand-grip strength (r = 0.445; P = .033) and serum albumin (r = 0.399; P = .05) and negatively correlated with serum C-reactive protein (r = -0.454;P= .05) and age. In linear multiple regression analysis, serum albumin (P= .033) and testosterone levels (P = .038) were shown to be predictors of hand-grip strength. However, we could not show a significant correlation between graft function and testosterone. Conclusions: Serum testosterone level is correlated with hand-grip strength and C-reactive protein and albumin levels, which may indicate that testosterone affects nutritional status and inflammation in male renal transplant recipients.
HOW CALCINEURIN INHIBITOR DOSAGE AND BLOOD TROUGH LEVELS AFFECT KIDNEY ALLOGRAFT SURVIVAL?
(2020) Turgut, Didem; Celebi, Zeynep Kendi; Ozdemir, B. Handan; Colak, Turan; Soy, Ebru H. Ayvazoglu; Haberal, Mehmet A.
Hyperproteinuria As A Cardiovasculary Risk Factor in Renal Transplant Recipients
(2014) Guliyev, Orhan; Uyar, Mehtap Erkmen; Sezer, Siren; Bal, Zeynep; Colak, Turan; Demirci, Bahar Gurlek; Acar, Nurhan Ozdemir; Haberal, Mehmet; https://orcid.org/0000-0002-7326-8388; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; JYQ-2550-2024; AAZ-5795-2021; AAJ-8554-2021; AAJ-8097-2021
Is Hyperuricemia Related to Morning Blood Pressure Surge and Non-Dipper Hypertension
(2015) Gurlekdemirci, Bahar; Sezer, Siren; Sayin, Burak; Erkmenuyar, Mehtap; Colak, Turan; Haberal, Mehmet; 0000-0002-8372-7840; 0000-0002-3462-7632; 0000-0001-8287-6572; AAJ-8554-2021; AAJ-8097-2021; IAO-2608-2023; J-3707-2015
Long-Term Results of Kidney Transplantation in Patients with Familial Mediterranean Fever
(2023) Bitik, Berivan; Hatipoglu, Bugra; Sayin, Burak; Kanbur, Aysenur Yalcintas; Bursa, Nurbanu; Oygur, Cagdas Sahap; Ozdemir, Handan; Colak, Turan; Haberal, Mehmet; Yucel, Ahmet Eftal; 0000-0001-5803-915X; 0000-0002-7528-3557; 0000-0002-3462-7632; 0000-0002-0168-2993; 36544375; AAI-9195-2021; X-8540-2019; AAJ-8097-2021
IntroductionLong-term kidney transplantation (KT) results in patients with familial Mediterranean fever (FMF)-related amyloidosis are not well studied. This study reviewed the long-term survival outcomes of FMF patients who underwent KT. MethodsWe compared the outcomes of 31 patients who underwent (KT) for biopsy-proven amyloidosis secondary to FMF with 31 control patients (five with diabetes mellitus and 26 with nondiabetic kidney disease) undergoing KT between 1994 and 2021 at Baskent University Hospital. All data were recorded retrospectively from patients' files. Results: The median age (quartile deviationQD) at the time of KT in the FMF and control group were 31 (6.7) and 33 (11), respectively. The median follow-up period (QD) after KT was 108 (57) months in the FMF and 132 (72) months in the control group. In the FMF group, graft and patient survivals were 71% and 84% at 5 years and 45% and 48% at 10 years, respectively. In the control group, graft and patient survivals were 79% and 100% at 5 years and 63% and 71% at 10 years, respectively. Patient survival in the FMF group at 5 years was significantly lower than in the control group (p = .045). There was no statistically significant difference between the FMF and control groups in terms of graft and patient survival, and serum creatinine levels at 10 years. All patients were given triple immunosuppressive treatment with cyclosporine, mycophenolate mofetil, and prednisolone. Three patients received anakinra and one received canakinumab in addition to colchicine treatment. One FMF patient also underwent heart transplantation due to AA amyloidosis. Of the FMF patients, 11 died during follow-up. ConclusionWe have found that the long-term outcome of KT in patients with FMF amyloidosis is numerically worse but not statistically different from the control group. However, short- and long-term complications still need to be resolved.
Morning Blood Pressure Surge In Renal Transplant Recipients: Its Relation To Graft Function And Arterial Stiffness
(2022) Demirci, Bahar Gurlek; Afsar, Baris; Tutal, Emre; Colak, Turan; 35704743
Background: When the blood pressure rises before awakening in the morning, it is called as morning blood pressure pulse (MBPS). MBPS is considered to be an independent risk factor for cardiovascular disease. The aim of this study was to investigate the associations between MBPS, graft function, arterial stiffness and echocardiographic indices in renal transplant recipients. Methods: Among 600 renal transplant recipients, 122 patients who had a history of hypertension and were taking at least one anti hypertensive medication were enrolled in the study. Arterial stiffness was measured by carotid-femoral pulse wave velocity (PWv), and echocardiographic indices were assessed. 24 h ambulatory blood pressure was monitored for all patients. MBPS was calculated by subtracting morning systolic blood pressure from minimal asleep systolic blood pressure. Results: Mean morning, day time and asleep systolic blood pressure values were 171.2 +/- 23.9, 137.9 +/- 18.1, and 131.7 +/- 18.9, respectively. Nondipper hypertension status was observed in 93 patients. Mean MBPS was 35.6 +/- 19.5 mm Hg, means PWv was 6.5 +/- 2.0 m/s. Patients with MBPS >= 35 mm Hg, had significantly lower eGFR and higher proteinuria, PWv. higher left atrium volume and LVMI. In regression analysis, day time systolic blood pressure, asleep systolic blood pressure, morning blood pressure surge, nondipper status and left ventricular mass index were detected as the predictors of graft function. Conclusions: Increased morning blood pressure surge is associated with graft dysfunction, increased arterial stiffness and LVMI that contribute to cardiovascular mortality and morbidity in renal transplant recipients.
The Mutation Identified in TWEAK-Fn14 Pathway May Affect the Clinical Course of IgA Nephropathy/Henoch-Schonlein Purpura Nephritis: A Case Report
(2021) Celebi, Zeynep Kendi; Turgut, Didem; Erdogmus, Siyar; Avsaroglu, Ezgi; Musabak, Haci Ugur; Colak, Turan
The TNF-like weak inducer of apoptosis (TWEAK) gene was first discovered in 1997 and its receptor Fn14 in 2001. TWEAK can be protective or damaging, depending on the status of the tissue. While basal TWEAK and Fn14 concentrations were found to be low in the kidney under normal conditions, TWEAK levels and tissue receptor expression were found to be increased in the presence of an acute injury.We report here the first case with persistent microscopic hematuria since infancy with TWEAK gene mutation, who was diagnosed with IgA Nephropathy/Henoch-Schonlein Purpura Nephritis at the age of 18 during a kidney biopsy. The genetic mutation in this patient may have caused a better course of the disease.
New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipients
(2015) Sezer, Siren; Uyar, Mehtap Erkmen; Tutal, Emre; Bal, Zeynep; Guliyev, Orhan; Colak, Turan; Hasdemir, Efe; Haberal, Mehmet; 25945353
Background. New-onset diabetes after transplantation (NODAT) is associated with decreased graft survival and an increased risk for cardiovascular disease. The objective of this study was to evaluate the risk factors for development of NODAT and its' relationship with arterial stiffness and left ventricular mass index (LVMI) in kidney transplant recipients. Methods. 159 kidney transplant recipients were selected from our transplantation center who underwent renal transplantation between years 2007 and 2010. Results. Among 159 patients, 57 (32.2%) patients were with NODAT who were significantly older than patients without diabetes (P: 0.0001). Patients with NODAT had significantly higher pulse wave velocity (PWv) (P: 0.033) and left ventricular mass index LVMI (P: 0.001) compared to patients without NODAT. Further analysis was done according to LVMI as follows: LVMI > 130 g/m(2) (n: 57) and LVMI <= 130 g/m(2) (n: 102). We observed higher office systolic and diastolic BP, serum trygliceride, glucose, creatinine, age, and HbA1c (P: 0.0001) levels in patients with LVMI > 130 g/m(2). Linear regression analysis revealed that HbA1c was the major determinant of LVMI (P: 0.026, beta: 0.361). Conclusions. HbA1c is the major determinant of LVMI, so strict control of serum glucose levels is essential for preventing cardiovascular disease in patients with NODAT.