Browsing by Author "Cenik, Fuat"

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Evaluation of the Relationship Between Thyroid Functions and Dry Eye Symptoms in Patients with Hashimoto Thyroiditis
(2017) Yalin, Gulsah Y.; Cenik, Fuat; Sayln, Nihat; Celik, Huseyin; Kumbasar, Abdulhaki
Purpose: Dry eye is the most common symptom of thyroid-associated ophthalmopathy in Hashimoto thyroiditis. Ocular surface inflammation, tear hyperosmolarity and overproduction of inflammatory cytokines are responsible for the development of this process. In this study, we aimed to investigate the relationship between thyroid functions and dry eye symptoms in patients with Hashimoto thyroiditis. Materials and Methods: The patients, diagnosed with Hashimoto thyroiditis (n:125), were included in this monocenter cross-sectional study. The study population was divided into three groups: euthyroidism (Group-1, n: 48), subclinical hypothyroidism (Group-2, n: 38) and overt hypothyroidism (Group-3, n: 39). The groups were compared based on the presence of dry eye syndrome, Schirmer tests, OSDI scores of patients with dry eye diagnosis and tear break-up time. The results were analyzed with ANOVA and Spearman's correlation test. Results: No significant difference was found in the frequency of dry eye syndrome between the groups (p = 0.1). There was no difference in the Schirmer scores and tear break-up time measurements (p = 0.6 and 0.2). The severity of OSDI scores was significantly milder in the patients with dry eye diagnosis, in the euthyroid group (p = 0.03). Serum fT3 levels positively correlated with tear break up time measurements (p = 0.004, r = 0.302) and negatively correlated with presence of dry eye syndrome (p = 0.03, r = -0.981). Discussion: Although dry eye symptoms tend to be milder in euthyroid patients, the frequency of dry eye syndrome is similar in patients with Hashimoto thyroiditis, independent of thyroid function status.
Relationship between Thyroid Volume and Baseline Vitamin D Levels in New-Onset Graves Disease
(2018) Yalin, Gulah Yenidunya; Celik, Huseyin; Cenik, Fuat; Yalin, Serkan Feyyaz
Objective: Serum vitamin D is shown to be decreased and associated with higher thyroid volumes in Graves disease (GD). We aimed to investigate the relationship between thyroid volume and baseline serum vitamin D status in newly diagnosed GD patients. Methods: This was a single-center cross-sectional study with a total of 61 new-onset GD patients (n=61, F: 40, M: 21) who were divided into two groups, according to baseline serum vitamin D levels, as Group-1 (vitamin D <20; n: 42) and Group-2 (vitamin D =20; n=19). Thyroid volume (mL) and isthmus measurements (mm) were compared between the two groups. Results: There was an inverse correlation between the baseline serum vitamin D levels and thyroid volume, thyroid receptor autoantibodies (TRAb), free triiodothyronine (fT3), and parathyroid hormone (PTH) levels (p=0.02, r=-0.31; p=0.005, r=-0.36; p=0.04, r=-0.26; p=0.02, r=-0.32, respectively). Thyroid volume was also correlated with serum free thyroxine (fT4), fT3, TRAb, and thyroid peroxidase autoantibodies (TPOAb; p=0.001, r=0.426; p=0.001, r=0.50; p=0.04, r=0.26; p=0.001, r=0.42, respectively). Low vitamin D and high thyroglobulin antibody (TgAb) levels were significantly associated with thyroid volume based on a regression analysis (p=0.03, odds ratio [OR]: 18.7, 95% confidence interval [CI]: 1.34-260.91 and p=0.04, OR: 16.6, 95% CI: 1.07-255.64, respectively). Conclusion: Baseline serum vitamin D levels are inversely related with thyroid volumes, fT3, and TRAb levels in new-onset GD. In addition to several advantages, optimization of vitamin D levels would also be beneficial in the surveillance of these patients. However, larger scale studies are required to make further suggestions.