Browsing by Author "Canpolat, Tuba"

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The Association of Upper Extremity Deep Vein Thrombosis and Homozygosity for the MTHFR 1298A-C Mutation in a Young Women with Membranoproliferative Glomerulonephritis
(2014) Yildiz, Ismail; Torun, Dilek; Ozelsancak, Ruya; Ozkan, Ugur; Canpolat, Tuba; 0000-0002-6267-3695; 0000-0002-0788-8319; AAD-9111-2021; AAD-5716-2021; AAK-8107-2021
Nephrotic syndrome increases the tendency to thromboembolic complications in both adults and children. Changes in the plasma concentrations of many proteins concerned with regulation of clotting and fibrinolytic systems, hyperviscosity, dehydration, corticosteroid and diuretic therapy may also contribute to thromboembolism. In addition, some of the genetic disorders also increase tendency to thromboembolic events. One of these disorders is methylene tetrahydrofolate reductase (MTHFR) A1298C mutation, which may cause hyperhomocysteinemia and thrombotic events when the folate level is low. A 26-year-old female was admitted to hospital with upper extremity deep vein thrombosis and nephrotic range proteinuria. On her renal biopsy, membranoproliferative glomerulonephritis (MPGN) was found. The other causes of thrombosis were excluded and homozygosity for the MTHFR A1298C mutation was determined. The levels of homocysteine and folic acid were normal. We report a first case of MPGN together with homozygosity for MTHFR 1298C mutation in adult nephrotic syndrome, complicated with unusual upper extremity venous thrombosis.
A Case of a Man With Isolated Breast Metastasis From Lung Adenocarcinoma Incidentally Detected by FDG PET/CT
(2016) Erhamamci, Seval; Reyhan, Mehmet; Canpolat, Tuba; Nursal, Gul Nihal; Yapar, Ali Fuat; https://orcid.org/0000-0001-8550-3368; https://orcid.org/0000-0002-5302-4386; https://orcid.org/0000-0003-1715-4180; 26562574; AAJ-5242-2021; AAK-8107-2021; R-3735-2016; AAI-8973-2021
Breast metastases from an extramammary primary tumor are very rare, particularly in men. In this study, we present a case of a 74-year-old man with isolated breast metastasis from lung adenocarcinoma as an incidental finding on PET/CT and diagnosed concomitantly with the primary tumor. Detection of isolated incidental metastatic lesions in the breast on PET/CT imaging has a significant clinical impact on patients with known malignant disease due to change of disease stage, management, and also treatment method.
Clinical and histopathological characteristics and differential diagnosis of chordomas
(2016) Canpolat, Tuba; Bal, Nebil; Cinar, Murat
Purpose: Chordomas are rare malignant bone tumours occuring in the midline of axial skeleton. We aimed to assess these tumors which has been diagnosed in our center in terms of clinical and pathologic characteristics, and differantial diagnosis difficulties. Material and Methods: We retrospectively evaluated cinical and histopathologic characteristics of 10 chordoma patients diagnosed at pathology department of Baskent University Adana Teaching and Resarch Hospital between 2009 and 2014. Results: The patients were consisted of men (n= 9) and women (n= 1) with the age of 61.3 (38-84) years old. The localization of chordomas were the sacrococcygeal region at eight patients (80%), lumbar vertebrae at one patient ( 10%) and clivus at one patient (10%). The mean diameter was 4.68 (2.5-7.5) cm. Histopathologically, majority of cases were "conventional chordoma" while one of them was "chondroid chordoma". Surgical excision was performed for all patients, only one case has recieved radiotherapy, and chemotherapy was given after surgery for one patient. Local recurrence was detected in three patients and distant metastasis (lung) was found in a patient and he died in a short time. Conclusion: Because that chordomas are rare clinical bone tumours which can be treated efficiently by appropriate surgical excision, clinical and histopathological characteristics and differential diagnosis should be well known.
Clinicopathological Evaluation of Childhood Sacrococcygeal Germ Cell Tumors: A Single-Center Experience
(2022) Hasbay, Bermal; Canpolat, Tuba; Aktekin, Elif; Ozkan, Hasan; Kekec, Senay Demir; 35781237
Objective: We aimed to evaluate the cases of sacrococcygeal germ cell tumors diagnosed in our hospital between 2006 and June 2021. Materials and Methods::We evaluated 38 sacrococcygeal germ cell tumors cases in our series in terms of age, sex, clinical complaints, localization, macroscopy, tumor size, histopathological diagnosis, surgical, postoperative complications, treatment, recurrence, and prognosis. Results: The cases ranged from 1 day to 16 years of age; 14 cases were diagnosed with routine ultrasonographic examination during prenatal period while the rest of the cases most frequently presented with complaints of constipation. In terms of localization, 6 cases were type 1, 11 cases were type 2, 6 cases were type 3, and 15 cases were type 4. In the pathological evaluation, 25 cases were mature teratoma, 8 cases were immature teratoma, and 5 cases were pure yolk-sac tumor. In terms of complications, temporary colostomy was performed as a result of rupture during birth in 2 cases, disseminated intravascular coagulation at birth in 1 case, and colon injury in 2 cases. There was a recurrence in 2 of our cases. Thirty-seven of our cases were alive and 1 died. Alpha-fetoprotein level was high in 28 of our cases. Conclusion: In our series, type 4 cases were observed more frequently, contrary to the literature. We recommend to use a routine ultrasonography to patients who come to the clinic with complaints of constipation and inability to urinate and if a mass is detected, asking for alphafetoprotein for further follow-up. Sacrococcygeal germ cell tumors are ultimately a disease that can be successfully treated with multidisciplinary approach, accurate diagnosis in the antenatal and postnatal period, appropriate surgical intervention, and regular follow-up.
Elastofibroma Dorsi Incidentally Detected by 18F-FDG PET/CT Imaging
(2015) Erhamamci, Seval; Reyhan, Mehmet; Nursal, Gul Nihal; Torun, Nese; Yapar, Ali Fuat; Findikcioglu, Alper; Canpolat, Tuba; 0000-0003-1715-4180; 0000-0002-5597-676X; 0000-0002-5302-4386; 0000-0001-8550-3368; 25666569; AAI-8973-2021; AAE-2718-2021; R-3735-2016; AFT-2303-2022; AAK-8107-2021; AAJ-5242-2021
Elastofibroma dorsi (ED) is a rare pseudotumor of the soft tissues that can also show 18F-fluorodeoxyglucose (F-18-FDG) uptake on positron emission tomography combined with computed tomography (PET/CT) imaging. The aim of this retrospectively study was to describe the metabolic characteristics of ED incidentally detected by F-18-FDG PET/CT imaging. Between November 2009 and August 2013 at our institution, 10,350 consecutive PET/CT examinations were retrospectively investigated. In 176 of these patients, ED was recorded as an incidental finding. Fifty-five of 176 patients also had follow-up scans after chemoradiotherapy. A total of 231 scans with ED in 176 patients were identified. To determine the metabolic activity of ED, the maximum standardized uptake value (SUVmax) was calculated semiquantitatively. For measurement size of ED, the longest axis of transaxial CT images was used. Seven of the 176 patients underwent surgery due to suspected metastases and/or invasion of primary malignancy and/or symptoms or incidental during surgery. The prevalence of ED in our series was 1.7 %. The lesions were located in the subscapular region in all patients, except in one case with a lesion in the infrascapular region. A total of 419 ED lesions in 231 scan of 176 patients were evaluated. Mean +/- A SD SUVmax and long axis values for these 419 lesions were 2.31 +/- A 0.61 (range 1.0-4.30) and 56.78 +/- A 17.01 mm (range 19-112 mm), respectively. Of these 176 patients, 141 (80.1 %) had bilateral lesions and 35 (19.9 %) had unilateral lesions. There were statistically significant differences in the SUVmax and long axis values between the right and left side in the bilateral lesions (p = 0.001). No significant differences in the SUVmax and long axis values of the lesion were found between pre- and posttreatment in the patients with follow-up scans. Elastofibroma dorsi located in the scapular region is usually bilateral, asymmetric and with mild or moderate metabolic activity on PET/CT imaging. In addition, the metabolic activity and size of ED remained stable after chemoradiotherapy. Awareness of these metabolic characteristics of ED is important for preventing misinterpretation during F-18-FDG PET/CT studies.
First case of cardiac amyloidosis presenting as right atrial mass
(2019) Acibuca, Aynur; Okar, Sefa; Canpolat, Tuba; Koc, Zafer; Gullu, Hakan; 0000-0003-1413-7393; 0000-0002-3444-8845; 31475954; AAF-2872-2020; ABG-4047-2020
Four-Year Analyses of Renal Graft Biopsies: A Single-Center Pathology Experience
(2017) Canpolat, Tuba; Ozdemir, Binnaz Handan; Torun, Dilek; Caliskan, Kenan; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-6267-3695; https://orcid.org/0000-0002-8767-5021; https://orcid.org/0000-0002-3462-7632; 27099951; AAK-8107-2021; X-8540-2019; AAD-9111-2021; AAJ-7201-2021; AAJ-8097-2021
Objectives: Kidney transplant is the best treatment for patients with end-stage renal disease. Long-term graft survival depends on the protection of renal allograft function. Renal allograft biopsy is the most important method for examining an allograft function. Biopsy provides critical information, enabling diagnosis and grading of pathologic changes, prediction of response to therapy, and long-term graft prognosis. Materials and Methods: We reviewed the medical records of patients who underwent renal transplant from living and deceased donors at Baskent University Adana Teaching and Research Hospital between 2010 and 2014 and who had an indication for biopsy. Clinical characteristics and laboratory results of patients were recorded. Patient biopsy samples were examined according to the Banff 2009 classification. Results: Between 2010 and 2014, there were 175 renal transplants performed at our hospital, with 134 recipients (76.6%) having living-donor and 41 recipients (23.4%) having deceased-donor transplants. Fifty-one patients (29.1%) were children, and 124 patients (70.9%) were adults. We found that there were 123 biopsies made from 75 transplant patients over a 4-year period. When examined according to Banff 2009 criteria, the biopsy samples revealed acute T-cell-mediated rejection alone in 14.1% of the samples, acute antibody-mediated rejection in 4%, and a combination of the 2 rejections in 5.7%. Specific infections were detected in 12 patients. The graft nephrectomy rate was 5.1%. Conclusions: This study investigated biopsy results, their relation with patient clinical status and 4-year survival rates, and our pathology experience and found that rejection and infection rates were similar to the literature. Our future studies with a longer follow-up and a larger sample size will likely provide more accurate information about graft survival and biopsy results.
Multifocal Soft Tissue Langerhans' Cell Histiocytosis Treated with PET-CT Based Conformal Radiotherapy
(2015) Onal, Cem; Oymak, Ezgi; Reyhan, Mehmet; Canpolat, Tuba; Ozyilkan, Ozgur; 0000-0002-2742-9021; 0000-0001-8550-3368; 0000-0001-8825-4918; 26211006; AGG-9214-2022; HOC-5611-2023; D-5195-2014; AAJ-5242-2021; AAD-2817-2021; AAK-8107-2021
Langerhans' cell histiocytosis (LCH) is a proliferative disorder of Langerhans cells, which is seen extremely rarely in adults. Conventional imaging modalities, such as skeletal surveys and bone scans, were accepted to be standard methods for diagnosis; however, 18-fluorodeoxyglucose positron emission tomography (PET-CT) has been increasingly used. We report on a 33-year-old female patient with disseminated LCH treated with radiotherapy and systemic chemotherapy where PET-CT has been used for defining the extent of the disease, RT planning and assessment of treatment response during follow-up. The patient was treated with 24 Gy 3-dimensional conformal radiotherapy (RT), given as 2 Gy a day, 5 days a week. The patient was also treated with systemic prednisolone 20 mg/m(2), concurrently. The chemotherapeutic regimen switched to cytosine-arabinoside with a dose of 100 mg/m(2) subcutaneously daily for 4 days, vincristine 1.5 mg/m(2) given on the 1st day and prednisolone 20 mg/m(2) for 4 cycles. After local RT with adjuvant chemotherapy, the patient was alive for 54 months and remained disease-free at last visit. RT is a treatment choice in multi-system LCH as well as solitary lesions. Low-dose RT is adequate to control large masses of LCH including soft tissue and lymph nodes.
Myofibroblastoma of the Breast
(2015) Aytac, Huseyin Ozgur; Bolat, Filiz Aka; Canpolat, Tuba; Pourbagher, Aysin; 28331720
This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblastoma (MFB). MFB is one of the rare, benign, spindle-like stromal tumors arising from the connective tissue of the breast. MFBs are often confused with fibroadenomas and hamartomas because of their benign characteristic appearance on breast imaging and are diagnosed after excisional biopsies. Their differential diagnosis with malignant neoplasia of the breast is important because of their wide morphological spectrum. Our case also demonstrated a breast mass with benign imaging characteristics and a needle core biopsy revealing a benign, spindle-like stromal tumor. The pathological examination performed after the excision of the lump demonstrated a collagenous-/fibrous-type MFB. This case report emphasizes the rare but important place of MFB variants of the breast in the differential diagnosis of breast mass.
Parotid gland tuberculosis accompanied by brucellosis
(2021) Inan, Serhat; Caylakli, Fatma; Canpolat, Tuba; 0000-0002-7333-2896; 0000-0001-8821-4481; AAP-7195-2020; AAJ-1407-2021
Almost one-fourth of the world's population is latently infected with Mycobacterium tuberculosis (MTB) with approximately 3% to 15% people at risk of progression to active disease during their lifetime. Parotid gland tuberculosis (TB) is an extremely rare form of extrapulmonary TB even in endemic areas. Parotid gland TB presents clinically as a unilateral, slow-growing, and possibly painless mass. Parotid gland TB tends to mimic parotid tumors without pathological evaluation. Risk factors for active infection in extrapulmonary TB forms are human immunodeficiency virus, malnutrition, diabetes mellitus, smoking, alcoholism, hematological malignancies, and immunosuppressive treatments. Brucellosis is a systemic disease that is transmitted from unpasteurized milk and dairy products obtained from an infected animal. It can affect many organs. Brucellosis is difficult to diagnose because its signs and symptoms are nonspecific and mimic many diseases. The aim of this case report is to present the clinical features, pathophysiology, diagnostic process, and treatment of a parotid gland TB case accompanied by brucellosis, the diagnosis and treatment of which were based on the suspicion of the clinician, in the light of the literature.
A Rare Cause of Left Ventricular Mass: Cardiac Hemangioma
(2018) Altin, Cihan; Gullu, Hakan; Bilgel, Ziya Gokalp; Yilmaz, Mustafa; Canpolat, Tuba; Gulcan, Omer; 29588260
A Rare Lesion of The Clitoris: Atypical Cellular Blue Naevus: Case Report
(2017) Ozdemir, Elif Didem; Yalcinkaya, Cem; Coban, Gonca; Canpolat, Tuba; Heper, Aylin Okcu; Celik, Husnu; https://orcid.org/0000-0002-3285-5519; 27924655; AAI-9974-2021; AAK-8107-2021; AAL-1923-2021
Venous thrombosis of sarcoidosis as an unusual incidental finding on 18F-fluorodeoxyglucose positron emission tomography/computed tomography
(2015) Erhamamci, Seval; Reyhan, Mehmet; Yapar, Ali Fuat; Canpolat, Tuba; 26430325
Sarcoidosis is defined as a multisystem granulomatous disorder of unknown cause. Venous thrombosis (VT) in the sarcoidosis is rare. The routine use of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has resulted in clinicians detecting many incidental findings, which have proven to be clinically significant such as thrombosis. Here, we present a case with VT of sarcoidosis in the inferior vena cava and portal vein as an unusual incidental finding on 18F-FDG PET/CT.
What are extraintestinal diagnostic tips in children with Crohn's disease?
(2019) Canan, Oguz; Durdu, Murat; Canpolat, Tuba