Browsing by Author "Cakmak, Soner"

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A Case of Simultaneous Mania and Idiopathic Normal Pressure Hydrocephalus: Etiology or Comorbidity?
(2019) Tunel, Munevver; Cakmak, Soner; Tamam, Lut; Demir, Turgay; 32594492
Normal pressure hydrocephalus (NPH), typically associated with the triad of gait disturbance, dementia and urinary incontinence, rarely presents with symptoms of mania, depression or psychosis and psychiatric disorders may complicate the diagnosis. Few cases of NPH and psychiatric disease comorbidity have been reported so far. In most of these cases, NPH was associated with depression and psychotic symptoms. Mania symptoms were also reported in a few cases those of which were associated with a history of bipolar disorder (BPD) or subthreshold BPD symptoms. In this paper, we present a case of late-onset mania symptoms simultaneously presenting with NPH in a healthy individual without a history of psychiatric disorder.
Effects of radiofrequency exposure on in vitro blood-brain barrier permeability in the presence of magnetic nanoparticles
(2022) Senturk, Fatih; Cakmak, Soner; Kocum, Ismail Cengiz; Gumusderelioglu, Menemse; Ozturk, Goknur Guler; 35134610
The blood-brain barrier (BBB) remains a major obstacle for the delivery of drugs in the treatment of many neurological diseases. In this study, we aimed to investigate the effects of radiofrequency electromagnetic fields (RF-EMFs) on the permeability of an in vitro BBB model under RF exposure alone, or in the presence of nanoparticles (NPs). For this purpose, an in vitro BBB model was established by seeding human umbilical vein endothelial cells (HUVECs) and human glioblastoma cell line (T98G) on the apical and basolateral sides of the transwell membrane, respectively. The integrity of the BBB model was confirmed by measuring transendothelial electrical resistance (TEER), and a fluorescein isothiocyanate (FITC)-dextran permeability assay was performed when the resistance reached 120 U cm(2). After the RFfield exposure (13.56 MHz, 80 W, 10 min), we found that FITC-dextran transported across the in vitro BBB was increased 10-fold compared to FITC-dextran transported without an RF-field. This notable phenomenon, which can be called the burst permeability RF effect (BP-RF), has been proposed for the first time in the literature. Subsequently, the effect of the RF-field on BBB permeability was also investigated in the presence of superparamagnetic iron oxide nanoparticles (SPIONs) and magnetic poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA-b-PEG) nanoparticles (m-PNPs). It was found that the amount of both transported NPs on the basolateral sides increased after exposure to the RF-field. As a result, the RFfield can be applied simultaneously during treatment with clinical agents or nanocarriers, improving the permeability of the BBB, which may contribute to therapeutic efficacy of many drugs that are used in neurological diseases. (c) 2022 Elsevier Inc. All rights reserved.
GRGDS-Conjugated and Curcumin-Loaded Magnetic Polymeric Nanoparticles for The Hyperthermia Treatment of Glioblastoma Cells
(2021) Senturk, Fatih; Cakmak, Soner; Kocum, Ismail Cengiz; Gumusderelioglu, Menemse; Ozturk, Goknur Guler
Thermally responsive and ligand-mediated drug delivery systems have the potential to improve the treatment of brain tumors, especially, most lethal one, glioblastoma multiform (GBM). Magnetic nanoparticle-mediated hyperthermia becomes one of the most promising alternative therapy for GBM treatment in cases where localized heating and targeted delivery of a therapeutic drug can be achieved on the tumor site. In this study, it is aimed to increase the therapeutic efficiency of multi-functionalized nanoparticles (NPs) in combination with radiofrequency hyperthermia (RF-HT) on GBM cells. For this purpose, firstly, a low-cost and portable home-built RFHT system suitable for in vitro/in vivo studies was successfully implemented and tested at 13.56 MHz frequency with power up to approximately 400 W. Subsequently, the highly monodispersed superparamagnetic iron oxide nanoparticles (SPIONs), which could interact with the RF magnetic field, were synthesized with the mean particle size of 5.6 +/- 0.9 nm. The obtained SPIONs were coated with poly (lactic-co-glycolic acid)-poly (ethylene glycol) di-block copolymer (PLGA-b-PEG). Most of the SPIONs were uniformly distributed in such a well-defined spherical-shaped polymeric NP. Moreover, curcumin (Cur), a potential agent for GBM treatment, was loaded into the magnetic polymeric nanoparticles (m-PNPs) with a loading capacity of 8% (w/w, Cur/NPs) and a mean diameter of Cur-loaded m-PNPs (Cur-m-PNPs) was 142 +/- 70 nm. To increase cellular uptake and targeting ability of NPs, glycine-arginine-glycine-aspartic acid-serine (GRGDS) peptide was immobilized on the Cur-m-PNPs and the amount of GRGDS was detected as 37 mu g/mg NPs. In vitro cytotoxicity studies revealed that the presence of GRGDS on Cur-m-PNPs (GRGDS-Cur-m-PNPs) improved the cytotoxic efficiency of Cur-m-PNPs by 6-fold in GBM-cells for all incubation times (24, 48 and 72 h). Furthermore, NPs with RF treatment exhibited higher antitumor activity than that of NPs without RF on GBM cells. This result may be attributed to the thermal (SPIONs) or non thermal (cellular membrane) effects or both of them on cells. Overall, this study showed that RF-HT in combination with GRGDS-Cur-m-PNPs could provide a feasible approach to improve GBM treatment.
Relationship between palpitation and chest pain and anxiety and depression symptom levels in individuals aged 18-25 years
(2019) Yigit, Fatma; Cakmak, Soner; Yilmaz, Mustafa; Uguz, Sukru
Purpose: The aim of this study is to compare the levels of anxiety and depression according to the presence and absence of heart disease in individuals aged 18-25 years who apply to the Cardiology Outpatient Clinic for palpitations or chest pain. Materials and Methods: Persons who 18-25 years old applied to Baskent University Adana Dr. Turgut Noyan Research and Application Center Cardiology Department for palpitaion or chest pain were taken into the study. A total of 114 people, including 55 males and 60 females, were included in the study. Fourty-four people those in the same ages who came as a companion were taken to the control group. Participants were asked to fill in the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) by themselves. Results: In the case group, 77 patients did not have any heart disease. Thirty-seven people were diagnosed with a heart disease. The BAI and BDI scores of the groups were compared. The BDI and BAI scores of the groups who presented with chest pain and palpitation were significantly higher than the control group. Conclusion: The anxiety and depression symptom levels of the patients who were diagnosed and not diagnosed with cardiac disease in 18-25 year olds who applied to the cardiology policlinic were more than the control group.