Browsing by Author "Bustaoglu, Ahmet"

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    In vitro activity of ceftolozane-tazobactam and ceftazidime-avibactam against clinical isolates of meropenem-non-susceptible Pseudomonas aeruginosa: A two-centre study
    (2020) Mirza, Hasan Cenk; Hortac, Elvan; Kocak, Aylin Altay; Demirkaya, M. Hamiyet; Yayla, Buket; Guclu, Aylin Uskudar; Bustaoglu, Ahmet; 0000-0002-1872-028X; 0000-0002-8853-3893; 0000-0002-0451-0142; 0000-0002-4335-6897; 31568882; AAU-6196-2020; F-1232-2015; AAI-8012-2021
    Objectives: This study aimed to compare the activity of ceftazidime-avibactam (C/A), ceftolozane-tazobactam (C/T) and three anti-pseudomonal beta-lactams (piperacillin-tazobactam, ceftazidime and cefepime) against a collection of meropenem-non-susceptible Pseudomonas aeruginosa (P. aeruginosa) clinical isolates recovered from two centres in Turkey. Methods: A total of 102 unique patient isolates of meropenem-non-susceptible P. aeruginosa were included in the study. MICs of antimicrobials were determined by the gradient diffusion method. Results: Overall susceptibility rates for C/A and C/T were 83.3% and 82.4%, respectively. Both C/A and C/T had better activity than any one of the three anti-pseudomonal beta-lactams. According to the MIC50 values, C/T was the most potent agent against isolates. Although the susceptibility rates of isolates to C/T and C/A were similar, C/T (MIC50, 1 mg/mL) was four-fold more potent than C/A (MIC50, 4 mg/mL). The MIC50 values of C/A and C/T for the isolates that were non-susceptible to three beta-lactams were significantly higher than those for isolates that were non-susceptible to zero, one or two beta-lactams. Also, the C/A MIC50 value for the isolates that were non-susceptible to two beta-lactams was higher than that for isolates which were non-susceptible to one beta-lactam. Conclusions: C/A and C/T showed good activity against meropenem-non-susceptible P. aeruginosa isolates. However, resistance to these agents was not uncommon among these isolates. The overall beta-lactam susceptibility profile of isolates seems to have an effect on the probability of susceptibility to C/A and C/T. Antimicrobial susceptibility testing should be performed for C/A and C/T if these agents are considered for treatment of infections caused by meropenem-non-susceptible P. aeruginosa. (C) 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd.