Browsing by Author "Bunyatova, Ulviye"

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Ag-Carried CMC/Functional Copolymer/ODA-Mt Wled-Treated NC And Their Responses to Brain Cancer Cells
(2018) Rzayev, Zakir M. O.; Bunyatova, Ulviye; Lovell, Jonathan F.; Shen, Weipeng; Thomay, Tim; Cartwright, Alexander; 0000-0002-9705-1722; 30184772; J-5194-2019
The subject of this work is synthesis and characterization of novel multifunctional nanocomposite (8/2A-NC) consisting (1) carboxymethyl cellulose (CMC) as a matrix biopolymer and poly (maleic acid-tilt-acrylic acid) as a reactive synthetic partner matrix polymer; (2) octadecyl amine montmorillonite (ODA-MMT) reactive organoclay provide intercalated silicate layers structures and aqueous colloidal dispersing medium, and MMT as carriers and targeting agents for anticancer agents in drug delivery systems, respectively. ODA as a intercalated surfactant finely dispersed 8/2A NC and its compatibility with matrix polymers via the interfacial polarization (complexing) and functionalization of matrix polymers by amine (ODA) and carboxylic acids from both the CMC and copolymer; (3) silver nanoparticles (AgNPs) as in-situ generated onto matrix polymers with unique nano-size and morphology parameters was synthesized. Important material science and bioengineering aspects of these investigations included (a) novel approach in synthetic pathways; (b) effects of physical and chemical structural rearrangements; (c) effects of Light Emitting Dioda (LED)-treatment on the FT-IR spectra, XRD reflection parameters, SEM-TEM morphology and nano-size and diameter distribution of AgNPs onto matrix polymers; (d) positive effect of LED-treatment of 8/2A nanocomposite and its response to the MIAPaCa-2 and U87 human brain cancer cell lines were evaluated. Novel 8/2A-NC multifunctional drug consisting unique positive, intercalating and encapsulated core-shell morphology structures, nano-size (5.6 run) and narrow diameter distribution (94%) of AgNPs onto matrix polymers [silver NPs (0.25%) in 8/2A NC (25%)] with highest volume of contact area compared with used cancer micro-cells show lowest cell viability as an excellent anticancer platform. 8/2A-NC is a novel multifunctional drug with intercalating and encapsulated core-shell morphology structures consisting of positively charged, non-randomly distributed AgNPs with a large contact area and low diameters (5-6 nm). The anticancer properties of (This factor is not conformed experimentally in work) this drug can be explained by the following structural factors: 8/2A-NC contains a combination of active sites from protonated hydroxyl, carboxyl and amine groups; Ag + -cations and ODA-MMT with high physical and chemical surface areas. We suggest this material be further explored for anti-cancer testing.
Biceps brachii kasının sagittal düzlemde hill kas modeli ile yenilikçi algoritması
(Başkent Üniversitesi Fen Bilimler Enstitüsü, 2024) Okan, Ayda; Bunyatova, Ulviye
Hill tipi kas modelleri, özellikle kas kuvvetlerinin doğrudan ölçümünün zor olduğu durumlarda, kas davranışını tahmin etmek ve anlamak için biyomekanik alanında yaygın olarak kullanılmaktadır. Ayrıca, anatomik yapılar üzerindeki iç kuvvetleri etkileyen dış yüklerden kaynaklanan insan vücudunun anatomik yapılarındaki değişiklikleri değerlendirmede değerli olduklarını kanıtlamaktadırlar. Bu dış yükler fiziksel çalışma ortamından kaynaklanabilir ve daha sonra uzuvların ve vücudun biyomekaniği yoluyla ortaya çıkabilir, böylece in vivo olarak çeşitli dokuları, kasları ve tendonları etkileyen iç yükleri etkileyebilir. Bu çalışmanın temel amacı; pandemi süreci ile masa başı çalışmaların artması, depremzedelerde kas iskelet sistemi deformasyonları oluşması, gündemde olan savaşlarda yaralanan kişi sayısında artış olması, sporcuların yaralanması sonucu rehabilitasyon süreci ve gündelik işlerde farkında olmadan kas iskelet sistemi kümülatif yaralanmaları gibi sebeplerin yanı sıra işle ilgili ya da günlük rutinlerdeki dış yüklerin neden olduğu iç kuvvetlerdeki değişiklikleri tahmin etmek, değerlendirmek ve önceden ele almak amacıyla Hill modeline dayalı bir modelleme çerçevesi oluşturmaktır. Bunların sonucu olarak, zaman içinde kademeli olarak biriken faktörlerin karmaşık bir etkileşimi olarak kas deformasyonları ortaya çıkabilir. Bu amaç doğrultusunda, Hill kas modeline dayalı matematiksel model tasarlanmış ve hem deneysel hem de sayısal yollarla doğrulanmıştır. Öncelikle Biceps Brachii kasının ve bu kasın alt tendonu olan Bisipital Aponevroz’un kas-tendon modellemesi yapılmıştır. Daha sonra Biopac Cihazı kullanılarak EMG sinyalleri elde edilmiştir. Biceps Brachii kasının matematiksel modeli oluşturulmuştur. Matlab’da kas-tendon modeline bağlı olarak ölçümlerde elde edilen EMG sinyalleri simüle edilmiştir. Sonuç olarak bu çerçevede; iç kuvvetlerin mevcut ve gelecekteki durumlarını değerlendirmek, kas iskelet sistemi bozukluklarını/rahatsızlıklarını tahmin etmek ve başka kaslar için de benzer analizlerin yapılabileceği, kas performansını etkileyen faktörleri araştırmak için bir platform sağlanmıştır. Ayrıca, protez ve ortez tasarımı ile rehabilitasyon süreçlerinin iyileştirilmesi, Parkinson hastalarının yaşam kalitesinin iyileştirilmesi gibi konularda gelecek vadedecek bir çalışma ortaya konmuştur. Hill-type muscle models are widely used in the field of biomechanics to predict and understand muscle behavior, especially when direct measurement of muscle forces is difficult. They are also proving to be valuable in assessing changes in the anatomical structures of the human body caused by external loads that affect the internal forces on the anatomical structures. These external loads can originate from the physical working environment and then manifest through the biomechanics of the limbs and body, thus influencing the internal loads affecting various tissues, muscles and tendons in vivo. The main purpose of this study is to create a modeling framework based on the Hill model to predict, evaluate and preemptively address changes in internal forces caused by external loads in work-related or daily routines, as well as reasons such as increased desk work with the pandemic process, musculoskeletal deformations in earthquake victims, an increase in the number of people injured in wars on the agenda, rehabilitation process as a result of injuries to athletes, and cumulative injuries to the musculoskeletal system unknowingly in daily work. As a result, muscle deformations can occur as a complex interaction of factors that gradually accumulate over time. For this purpose, a mathematical model based on the Hill muscle model was designed and validated both experimentally and numerically. First of all, muscle-tendon modeling of the Biceps Brachii muscle and its inferior tendon, the Bicipital Aponeurosis, was performed. Then EMG signals were obtained using the Biopac System. A mathematical model of the Biceps Brachii muscle was created. EMG signals obtained in measurements were simulated in Matlab depending on the muscle-tendon model. As a result, this framework provides a platform for evaluating the current and future status of internal forces, predicting musculoskeletal disorders/discomforts, and investigating the factors affecting muscle performance, where similar analyses can be performed for other muscles. In addition, a promising study on prosthesis and orthosis design, improving rehabilitation processes and improving the quality of life of Parkinson's patients has been put forward.
Functional Copolymer/Organo-MMT Nanoarchitectures. XXII. Fabrication and Characterization of Antifungal and Antibacterial Poly (Vinyl Alcohol-co-Vinyl Acetate/ODA-MMT/AgNPs Nanofibers and Nanocoatings by e-Spinning and c-Spinning Methods
(2015) Rzayev, Zakir M. O.; Erdonmez, Demet; Erkan, Kubra; Simsek, Murat; Bunyatova, Ulviye; 0000-0002-2904-3587
Nanofibrous films and coatings were fabricated by electrospinning and centrifugal spinning of aqueous solutions of poly(vinyl alcohol-co-vinyl acetate)/octadecyl amine-montmorillonite layered silicate nanocomposites with/without in situ generated silver nanoparticles (AgNPs). Characterization of nanofibers were realized by FTIR, XRD, SEM, and thermal analysis methods. It was found that AgNPs significantly accelerated phase separation process providing fine distribution of nanofibers. Antifungal and antimicrobial activities of nanocomposites investigated by using Candida Spp fungals, G-positive and G-negative microorganisms strongly depended on chemical/physical structural factors, and loading silver species. Observed effective properties of nanomaterials can be employed for many applications (e.g., air filtration, food packaging, biomedical).
Functional Organo-Mt/Copolymer Nanoarchitectures. Microwave-Assisted Rapid Synthesis and Characterisation of ODA-Mt/poly[NIPAm-co-(MA-alt-2,3-2H-DHP)] Nanocomposites
(2015) Rzayev, Zakir M. O.; Uzgoren-Baran, Ayse; Bunyatova, Ulviye; 0000-0002-2904-3587
In this work, novel octadecyl amine-montmorillonite (ODA-Mt) copolymer nanocomposites were synthesised by interlamellar microwave-assisted complex-radical copolymerisation. The microwave method is found to be a facile and highly effective means to clay polymer nanocomposites (CPNs) that provide a higher rate of interlamellar copolymerisation and conversion of micro- and nanoparticles. The chemical and physical structures, surface morphologies and thermal behaviours of the prepared CPN were investigated by FTIR and H-1 (C-13) NMR spectroscopy, XRD, SEM, TEM, thermal (DSC and TGA) and dynamic mechanical (DMA) analysis methods. That copolymerisation was accompanied by in situ complex formation (charge transfer complex and H-bonding similar with known copolymerisation without ODA-Mt) and the intercalative amidisation of anhydride units with the octadecyl amine groups of Mt was determined. These observed chemical and physical interfacial interactions as effective in situ processing play an important role in the formation of hybrid systems and micro- and nanocomposites with stimuli-responsive NIPAm polymer chains. (C) 2014 Elsevier B.V. All rights reserved.
Görünür ışığa duyarlı ag taşıyıcılı – CMC/MA/ODA-MMT’nin AgNP üretimini aktive eden kompakt sistem tasarımı ve üretilen nanokompozitin antimikrobiyal analizi
(Başkent Üniversitesi Fen Bilimleri Enstitüsü, 2021) Çıkmaz Hoca, Helin; Bunyatova, Ulviye
Gümüş nanopartiküllerin antimikrobiyal olarak kullanılma çalışmaları son yıllarda giderek artmaktadır. Bu nedenle çeşitli gümüş (Ag) taşıyıcılı polimer yapıları oluşturulup, farklı yöntemler ile gümüş nanopartikül (AgNP) oluşumu teşvik edilmektedir. Bu tezin amacı; üç farklı dalga boyundaki (mavi, yeşil, kırmızı renklerindeki) görünür ışığın Ag-taşıyan CMC/MA/ODA-MMT nanokompozitte nanopartikül oluşumuna etkisi, bu aktivasyon prosesinin incelenmesi ve takibi için düşük maliyetli bir sistem tasarlanmıştır. Literatürde üç farklı görünür dalga boyunda aktivasyon sağlayıp hem de aktivasyonun gerçekleştiğini verilerle gösterebilen bir sisteme rastlanamamıştır. Bu nedenle kompakt ve düşük bir maliyetli el yapımı bir sistem tasarlanmış, üç farklı dalga boyundaki (yeşil, mavi, kırmızı renklerindeki) görünür ışık ile Ag-taşıyan CMC/MA/ODA-MMT nanokompozit, nanopartikül oluşumu için aktive edilmiş ve bu aktivasyon PIN fotodiyotlar ile algılanarak aktivasyon süreleri gözlemlenmiştir. Tasarlanan sistemle AgNP’lerin oluşum süresi boyunca potansiyel farkı tespit edilirken aktivasyon prosesinin bitişiyle potansiyel farkın sabitlendiği gözlemlenmiştir. Nanokompozit aktivasyonundan sonra mavi, yeşil ve kırmızı LED’ler ile aktive edilen numunelerin potansiyel fark- zaman eğrileri analiz edilmiştir. Aktivasyon süresince tüm LED’lerden alınan potansiyel farkının zamana karşı eksponansiyal eğri ile azaldığı tespit edilmiş, aktivasyon prosesinin bitişiyle potansiyel farkın sabitlendiği gözlemlenmiştir. Nanokompozitin aktivasyondan sonra her bir dalga boyu ile aktive edilen numunenin TEM-SEM analizleri, antimikrobiyal testleri yapılarak numuneler nanopartikül boyutları, antimikrobiyal aktiviteleri bakımından kıyaslanmıştır. Farklı dalga boylarıyla AgNP aktivasyonu yapılmış AgNP/CMC/MA/ODA-MMT’nin nanopartikül boyutlarında, LED’lerin enerji değerlerine göre kıyaslandığında; enerjisi yüksek olan LED’in AgNP boyutunun küçük olduğu tespit edilmiştir (AgNP boyut ortalamaları sırasıyla mavi LED ile aktive edilen numunenin 4-6 nm, yeşil LED ile aktive edilen numunenin 6-8 nm ve kırmızı LED ile aktive edilen numunenin 12-14 nm). Dalga boyunun yani enerjinin aktivasyon süresine etkili olduğu tespit edilmiştir. Enerjisi en yüksek olan LED’in AgNP aktivasyon süresinin daha kısa olduğu ölçülmüştür (ortalama aktivasyon süreleri sırasıyla mavi LED ile aktive edilen numunenin 12 dakika, yeşil LED ile aktive edilen numunenin 18 dakika ve kırmızı LED ile aktive edilen numunenin ise 24 dakikadır). Antimikrobiyal aktiviteyi gözlemlemek ve konsantrasyonun (2,5 mg/ml, 0,5 mg/ml, 0,1 mg/ml, 0,05 mg/ml, 0,01 mg/ml, 0,005 mg/ml, 0,001 mg/ml, 0 mg/ml) antimikrobiyal aktivite üzerindeki etkisini gözlemlemek için disk difüzyon testi yapılmıştır. Disk difüzyon testinin (Gram negatif E.coli 25922, P.aeruginosa 27853, Gram pozitif E.faecalis 29212 bakterileri ve maya olarak Candida albicans 10231) yapıldığı AgNP/CMC/MA/ODA-MMT’nin antimikrobiyal aktivitesinde numunelerin nanopartikül boyutları yaklaşık olarak aynı olduğu için nanopartikül boyutunun (dalga boyunun) anlamlı bir farklılık yaratmadığı gözlemlenmiştir. AgNP/CMC/MA/ODA-MMT konsantrasyonu yüksek olan numunelerin antimikrobiyal aktivitesinin yüksek olduğu gözlemlenmiştir. Bu çalışma için antimikrobiyal aktivitede AgNP/CMC/MA/ODA-MMT’nin konsantrasyonun etkili olduğu gözlemlenmiştir. Çalışmanın sonuçlarına bakarak Covid-19 ile mücadele edilen bu dönemde çevreye zararsız ve kontrollü bir şekilde antimikrobiyal nanomalzeme üretmek için kullanımı kolay, kompakt ve düşük maliyetli bir antimikrobiyal sistem tasarlandığı söylenebilmektedir. The use of silver nanoparticles as antimicrobials has been increasing in recent years. For this reason, various silver (Ag) carrier polymer structures are formed and silver nanoparticle (AgNP) formation is encouraged by different methods. The aim of this thesis is; The effect of visible light in three different wavelengths (blue, green, red colors) on the nanoparticle formation in Ag-carrying CMC / MA / ODA-MMT nanocomposite, a low-cost system has been designed for the investigation and monitoring of this activation process. In the literature, no system has been found that can provide activation at 3 different visible wavelengths and show the activation occurred with data. For this reason, a compact and low cost handmade system was designed, activated with visible light in three different wavelengths (green, blue, red colors) for the formation of nanoparticles in Ag-carrying CMC / MA / ODA-MMT nanocomposite, and this activation was carried out with PIN photodiodes were detected and activation times were observed. With the designed system, it was observed that the potential difference was determined during the formation period of AgNPs, while the potential difference was set at the end of the activation process. The potential difference-time curves of the samples activated by blue, green and red LEDs after the nanocomposite activation were analyzed. It was determined that the potential difference taken from all LEDs during activation decreased with the exponential curve against time, and it was observed that the potential difference was set at the end of the activation process. After the activation of the nanocomposite, TEM-SEM analyzes and antimicrobial tests of the samples activated by each wavelength were performed and the samples were compared in terms of nanoparticle sizes and antimicrobial activities.When nanoparticle sizes of AgNP / CMC / MA / ODA-MMT with different wavelengths are activated compared to the energy values of LEDs; It has been determined that the AgNP size of the LED with high energy is small (the average nanoparticle size is 4-6 nm for the sample activated by the blue LED, 6-8 nm for the sample activated by the green LED and 12-14 nm for the sample activated by a red LED). It has been determined that the wavelength, i.e. the energy, is effective on the activation time. It was measured that the AgNP activation time of the LED with the highest energy was shorter (average activation times were 12 minutes for the sample activated by the blue LED, 18 minutes for the sample activated by the green LED, and 24 minutes for the sample activated with a red LED, respectively). To observe antimicrobial activity and concentration (2,5 mg / ml, 0,5 mg / ml, 0,1 mg / ml, 0,05 mg / ml, 0,01 mg / ml, 0,005 mg / ml, 0,001 mg / ml A disk diffusion test was performed to observe the effect on antimicrobial activity (0 mg / ml). In the antimicrobial activity of AgNP / CMC / MA / ODA-MMT where the disk diffusion test (Gram negative E.coli 25922, P.aeruginosa 27853, Gram positive E.faecalis 29212 bacteria and Candida albicans 10231 as fungi) was performed, the nanoparticle sizes of the samples were approximately the same. It has been observed that nanoparticle size (wavelength) does not make a significant difference. It was observed that samples with high AgNP / CMC / MA / ODA-MMT concentrations had high antimicrobial activity. For this study, it was observed that the concentration of AgNP / CMC / MA / ODA-MMT was effective in antimicrobial activity. Based on the results of the study, it can be said that an easy to use, compact and low cost antimicrobial system was designed to produce antimicrobial nanomaterials in a controlled stage and harmless to the environment in this period, which was struggling with Covid-19.
Multifunctional Colloidal Nanofiber Composites Including Dextran and Folic Acid As Electro-Active Platforms
(2017) Rzayev, Zakir M. O.; Bunyatova, Ulviye; Simsek, Murat; 28385251
This work presents the fabrication and characterization of novel colloidal multifunctional polymer nanofiber composites (NFCs) from water dispersion blends of intercalated silicate layered nanocomposites of poly (2-vinyl-N-pyrrolidone)/octadecyl amine-montmorillonite (ODA-MMT) and dextran/ODA-MMT as matrix and partner polymer intercalated nanocomposites in the presence of NaOH and folic acid (FA) as doping agents by green reactive electrospinning. Chemical and physical structures, surface morphology and electrical properties were investigated. Effects of matrix/partner polymer ratios, doping agents, absorption time of NaOH, and temperature on electrical parameters of NFCs were evaluated. The presence of FA and increasing dextran fraction in NFCs resulted in reducing fiber diameter and improving diameter distribution. High complexing behaviors of matrix/partner polymer chains, organoclay, FA, and NaOH significantly improved conductivity parameters, especially 5-min of absorption time (approximate to 10(-2)-10(-3) Sm-1). The conductivity of the samples decreased with increasing temperature. NFCs fabricated for the first time are promising candidates for various biomedical, electrochemical and electronic applications as electro-active platforms. (C) 2017 Elsevier Ltd. All rights reserved.
Novel Concept On In Situ Syntheses And Investigation Of Photon Energy Effect On Agnp Size With A Custom Build Device For Enhanced Antimicrobial Efficiency
(2022) Bunyatova, Ulviye; Kocum, Ismail Cengiz; Turkmen, Kubra Erkan; Haberal, Orhan Erdem; Kocak, Onur; Koca, Helin Cikmaz; 10.1007/s11051-022-05612-2
The objectives of the present study were to examine the influence of visible light photons on photoreduction of the silver nanoparticles (AgNPs), detect optoelectronic feedback, and observe the antimicrobial activity. For this purpose, an optoelectronic device was designed and successfully tested. The finding shows that identical nanocomplexes with silver salt express various responses to the LEDs with different wavelengths by scattering different portions of light. It is the first time to discuss the effect of visible light photons on nanosized particles in detail based on the quantitative optical/voltage analysis. The photoreduction of the AgNPs is in good agreement with photon energy and the AgNPs occur in nanocomplex in a wavelength versus time-dependent mariner. The blue LED having photon energy 7.04 eV reduces the average size of AgNPs down to the range 4-6 nm in 12 min, while AgNPs obtained under influence of green (6.11 eV) and red (5.04 eV) LEDs have average sizes 6-8 nm and 12-14 nm respectively. The successful synthesis of AgNPs was additionally examined using UV-Vis, SEM, XPS, XRD, FTIR, and TEM techniques. AgNPs proved for antimicrobial activity against Escherichia coli 25922, Enterococcus faecalis 29212, Pseudomonas aeruginosa 27853, and Candida albicans 10231 at four different concentrations. The antibacterial test for all selected bacteria showed that AgNPs which have an average size of 4-6 nm synthesized by blue LED revealed the largest inhibition zone around 16-11 mm, while the antifungal test shows that the maximum inhibition zone was exposed by AgNPs which have an average size of 6-8 nm synthesized by red LED.
Novel light-driven functional AgNPs induce cancer death at extra low concentrations
(2021) Bunyatova, Ulviye; Ben Hammouda, Manel; Zhang, Jennifer; ; 34168242
The current study is aimed at preparing light-driven novel functional AgNPs-bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16-18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synthesized using a soft white LED approach and analyzed by UV-Vis, DLS, FTIR, X-ray, SEM-EDX and TEM techniques. The anticancer activity of the obtained novel functionalized AgNPs@C_MA_O was tested in-vitro in the A375 melanoma cell line. Dose-response analysis showed that AgNPs at 0.01 mg/mL and 0.005 mg/mL doses reduced the viability of A375 cells by 50% at 24 and 48-h time-points, respectively. A375 cells treated with AgNPs@C_MA_O for 24 h at IC50 displayed abnormal morphology such as detachment edges and feet, shrinkage, membrane damage, and the loss of contact with adjacent cells. Our work is the first study showing that non-ionizing radiation mediated biofunctionalized AgNPs have an anti-tumoral effect at such a low concentration of 0.01 mg/mL. Our approach of using harmless wLED increased synergy between soft biopolymer compounds and AgNPs, and enhanced anticancer efficiency of the AgNPs@C_MA_O biohydrogel. Ultimately, the AgNPs accessed through the use of the wLED approach in colloidal syntheses can open new applications and combinatorial advanced cancer treatments and diagnostics.
A Novel Portable Nanotechnology Approach for Targeted Cancer Therapy
(2018) Bunyatova, Ulviye; Kocum, Cengiz; Haberal, Erdem; Asadullayev, Alaskar; Salamov, Gulbala; 0000-0003-2788-550X; ABC-8833-2020
Several health-related problems can be monitored, treated and minimized with the use of technological equipment and treatment methods. The development of new synthesis methods and designing nanostructured biosensing colloidal polymeric bioorganic nanomaterials and metal using cheap and environmentally friendly methods remains a challenge to the scientific community. This study is focused on the presentation a new approaches to targeted treatment with a novel portable sensing system. We have found that aqueous blend of intercalated polysaccharides nanocomposites with a reactive functionalizing copolymer and silver nanoparticules (AgNP-s) are sensitive towards a visible light source-white light emitted diode (wLED). The presented system and ideas can be used as an integrated pathways for targeted cancer therapy, biosensors, and drug delivery systems. AgNP-s, having unique sizes in the range between 2 -6 nm have been obtained by the influence of harmless wLED treatment during extremely short time around 10-12 minutes. wLED based portable wire-device is an effective route to obtain bio-nanocomposition with anticancer and drug delivery potential as a pathway of targeted cancer therapy. Moreover, after applying multifunctional biocomposition on the tumor area this effective, eco-friendly, low cost and harmless for human health treatment takes only 10-12 minutes.
Ultra-Stable Nano-Micro Bubbles In A Biocompatible Medium For Safe Delivery Of Anti-Cancer Drugs
(Başkent Üniversitesi Mühendislik Fakültesi, 2024-04-04) Bunyatova, Ulviye; Dogan, Mustafa; Tekin, Engincan; Ferhanoglu, Onur
We conducted a series of experimental investigations to generate laser-stimulated millimeter bubbles (MBs) around silver nanoparticles (AgNPs) and thoroughly examined the mechanism of bubble formation within this nanocomposite system. One crucial aspect we explored was the lifetime and kinetics of these bubbles, given that bubbles generated by plasmonic nanoparticles are known to be transient with short durations. Surprisingly, our findings revealed that the achieved lifetime of these MBs extended beyond seven days. This impressive longevity far surpasses what has been reported in the existing literature. Further analysis of the experimental data uncovered a significant correlation between bubble volume and its lifetime. Smaller bubbles demonstrated longer lifetimes compared to larger ones, which provided valuable insights for future applications. The experimental results not only confirmed the validity of our model and simulations but also highlighted essential characteristics, including extended lifetime, matching absorption coefficients, adherence to physical boundary conditions, and agreement with simulated system parameters. Notably, we generated these MBs around functionalized AgNPs in a biocompatible nanocomposite medium by utilizing low-power light excitation. By readily binding potent cancer drugs to AgNPs through simple physical mixing, these medications can be securely encapsulated within bubbles and precisely guided to targeted locations within the human body. This capability to deliver drugs directly to the tumor site, while minimizing contact with healthy tissues, can lead to improved treatment outcomes and reduced side effects, significantly enhancing the quality of life for cancer patients.