Browsing by Author "Bacakoglu, Feza"

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Context Sensitive Links The Role of Aerolized Colistin in the Treatment of Hospital-Acquired Pneumonia: Experience of Multicenter From Turkey: Erratum (vol 44, pg e304, 2016)
(2018) Ekren, Pervin Korkmaz; Toreyin, Nur; Takir, Huriye Berk; Balci, Merih Kalamanoglu; Gaygisiz, Ummugulsum; Gursel, Gul; Ergan, Begum; Yalcin, Aslihan; Salturk, Cuneyt; Aydogdu, Muge; Ergun, Recai; Guven, Pinar; Ulubay, Gaye; Kaya, Aslihan Gurun; Celtik, Aygul; Uluer, Hatice; Bacakoglu, Feza; Sayiner, Abdullah; https://orcid.org/0000-0003-2478-9985; AAB-5064-2021
Evaluation of nephrotoxicity and prognosis in patients treated with colistin due to hospital-acquired pneumonia
(2017) Ulubay, Gaye; Korkmaz Ekren, Pervin; Toreyin, Zehra Nur; Berk Takir, Huriye; Kalamanoglu Balci, Merih; Gaygisiz, Ummugulsum; Gursel, Gul; Ergan, Begum; Yalcin, Aslihan; Saltürk, Cuneyt; Aydogdu, Muge; Ergun, Recai; Guven, Pinar; Gurun Kaya, Aslihan; Celtik, Aygul; Uluer, Hatice; Bacakoglu, Feza; Sayiner, Abdullah; 0000-0003-2478-9985; 29631525; AAB-5064-2021
Introduction: Colistimethate sodium (CMS) is frequently used in the treatment of nosocomial multidrug-resistant gram-negative infections. Nephrotoxicity is the most important side effect. The aim of this study is to evaluate the effect of colistin on nephrotoxicity and to assess prognosis in patients treated with CMS due to hospital-acquired pneumonia (HAP). Materials and Methods: Patients treated with CMS for HAP due to multidrug-resistant Pseudomonas aeruginosa or Acinetobacter baumannii were included in this cohort study. Results: We evaluated 281 patients treated with two different brands of CMS whose administration dose is different: imported (n=58, low dose/kg) and domestic (n=223, high dose/kg). Nephrotoxicity developed in 175 patients (62.3%). The median age (73 vs. 66 years, p=0.004) and mortality rates were higher (66.9% vs. 52.8%, p=0.022) in patients having nephrotoxicity. The patients receiving high dose/kg had higher nephrotoxicity rate (67.7% vs. 41.4%, p < 0.001). The clinical, bacteriological response and mortality rates of the whole group were 52.0%, 61.0%, 61.6%, respectively. The clinical and bacteriological response rates were similar in the different dose groups. Multivariate analysis showed that nephrotoxicity was associated with domestic brand depending on use of high dose (OR=3.97), advanced age (beta=0.29, p=0.008), male gender (OR=2.60), hypertension (OR=2.50), red blood cells transfusion (OR=2.54), absence of acute kidney injury (OR=10.19), risk stage of RIFLE (OR=11.9). Conclusion: Nephrotoxicity is associated with the use of high dose colistin, age, gender, hypertension, red blood cells replacement and RIFLE stage. The mortality rate is higher in patients developing nephrotoxicity.
Outcome of Patients Admitted to Intensive Care Units due to Influenza-Related Severe Acute Respiratory Illness in 2017-2018 Flu Season: A Multicenter Study from Turkey
(2020) Ortac Ersoy, Ebru; Er, Berrin; Ciftci, Fatma; Gulleroglu, Aykan; Suner, Kezban; Arpinar, Burcu; Aygencel, Gulbin; Bacakoglu, Feza; Akpinar, Serdar; Comert, Bilgin; Sungurtekin, Hulya; Altintas, Defne; Rollas, Kazim; Turan, Sema; Topeli, Arzu; 0000-0002-6091-9065; 33271560; AAJ-4188-2021
Background: Influenza can cause severe acute respiratory illness (SARI), which occurs as local outbreaks or seasonal epidemics with high intensive care unit (ICU) admission and mortality rates. Mortality is mainly due to SARI. Objective: The aim of this study was to evaluate the outcome of patients admitted to ICU due to influenza-related SARI in 2017-2018 flu season in Turkey. Methods: A retrospective multicenter study was conducted in 13 ICUs with a total of 216 beds from 6 cities in Turkey. All adult patients (over 18 years) admitted to the ICUs in 2017-2018 flu season (between September 1, 2017, and April 30, 2018) because of SARI and with a positive nasopharyngeal swab for influenza were included in the study. Results: A total of 123 cases were included in the study. The mean age of patients was 64.5 +/- 17.5 years, and 66 (53.7%) patients were older than 65 years. The ICU mortality was 33.9%, and hospital mortality was 35.6%. Invasive mechanical ventilation (IMV), acute kidney injury (AKI), hematologic malignancy, and >65 years of age were the factors affecting mortality in influenza. Conclusion: SARI due to influenza carries a high mortality rate, and IMV, AKI, presence of hematologic malignancy, and older age are independent risk factors for mortality.
The Role of Aerolized Colistin in the Treatment of Hospital-Acquired Pneumonia: Experience of Multicenter From Turkey: Erratum (vol 44, pg e304, 2016)
(2018) Ekren, Pervin Korkmaz; Toreyin, Nur; Takir, Huriye Berk; Balci, Merih Kalamanoglu; Gaygisiz, Ummugulsum; Gursel, Gul; Ergan, Begum; Yalcin, Aslihan; Salturk, Cuneyt; Aydogdu, Muge; Ergun, Recai; Guven, Pinar; Ulubay, Gaye; Kaya, Aslihan Gurun; Celtik, Aygul; Uluer, Hatice; Bacakoglu, Feza; Sayiner, Abdullah; 0000-0003-2478-9985; AAB-5064-2021