Browsing by Author "Azap, A."

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    Antibiotic overconsumption and resistance in Turkey
    (2019) Isler, B.; Keske, S.; aksoy, M.; Azap, O. K.; Yilmaz, M.; Yavuz, S.S.; Aygun, G.; Tigen, E.; Akalin, H.; Azap, A.; Ergonul, O.; 30844434
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    Healthcare-Associated Gram-Negative Bloodstream Infections: Antibiotic Resistance and Predictors Of Mortality
    (2016) Ergonul, O.; Aydin, M.; Azap, A.; Basaran, S.; Tekin, S.; Kaya, S.; Gulsun, S.; Yoruk, G.; Kursun, E.; Yesilkaya, A.; Simsek, F.; Yilmaz, E.; Bilgin, H.; Hatipoglu, C.; Cabadak, H.; Tezer, Y.; Togan, T.; Karaoglan, I.; Inan, A.; Engin, A.; Aliskan, H. E.; Yavuz, S. S.; Erdinc, S.; Mulazimoglu, L.; Azap, O.; Can, F.; Akalin, H.; Timurkaynak, F.; https://orcid.org/0000-0003-4044-9366; https://orcid.org/0000-0001-9060-3195; 27717604; HLX-0937-2023; AAE-2282-2021
    This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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    Rapid Emergence of Colistin Resistance and Its Impact on Fatality Among Healthcare-Associated Infections
    (2018) Aydin, M.; Ergonul, O.; Azap, A.; Bilgin, H.; Aydin, G.; Cavus, S. A.; Demiroglu, Y. Z.; Aliskan, H. E.; Memikoglu, O.; Menekse, S.; Kaya, S.; Demir, N. A.; Karaoglan, I.; Basaran, S.; Hatipoglu, C.; Erdinc, S.; Yilmaz, E.; Tumturk, A.; Tezer, Y.; Demirkaya, H.; Cakar, S. E.; Keske, S.; Tekin, S.; Yardimci, C.; Karakoc, C.; Ergen, P.; Azap, O.; Mulazimoglu, L.; Ural, O.; Can, F.; Akalin, H.; https://orcid.org/0000-0003-4044-9366; 29248504; HLX-0937-2023
    This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.