Browsing by Author "Ayva, Sebnem"

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    Comparison of Recipients with Early and Later Presentation Polyomavirus Nephropathy (PVN) with Regard to Histological Findings and Graft Survival: What is the Influence of CD4/CD8 Ration on the Presenting Time of PVN
    (2018) Ozdemir, B. Handan; Ayva, Sebnem; Terzi, Aysen; Atilgan, Alev Ok; Akcay, Eda; Soy, Ebru H. Ayvazoglu; Acar, F. Nurhan Ozdemir; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0002-1225-1320; 0000-0001-8595-8880; 0000-0001-6831-9585; 0000-0002-0993-9917; 0000-0002-5682-0943; 0000-0002-3462-7632; X-8540-2019; AAK-1967-2021; F-7546-2013; AAK-3333-2021; AAK-1960-2021; AAC-5566-2019; AAK-1697-2021; AAJ-8097-2021
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    First Reported Case of Echinococcal Disease on a Renal Graft Successfully Treated With Albendazole
    (2021) Helvaci, Ozant; Dagli, Pinar Akyuz; Ayva, Sebnem; Dalgic, Aydin; Sozen, Hakan; Dizbay, Murat; Arinsoy, Turgay; Derici, Ulver Boztepe; 0000-0002-2280-8778; 30696396; AAK-1967-2021
    Echinococcal disease is an endemic disease for eastern Mediterranean countries. Various types of kidney involvement have been reported. Here, we report the first case of echinococcal disease on a transplanted kidney in a patient who was successfully treated with albendazole alone. The patient (a 38-year-old female) was evaluated for elevated creatinine levels 7 months after receiving a living-donor allograft. Standard immunosuppression therapy protocols were applied. Tacrolimus level was normal, and the patient was compliant with treatment. Creatinine level was 1.91 mg/dL (baseline: 1.2 mg/dL); proteinuria level was 1300 mg/day. The graft was found to be normal, as evaluated with standard sonographic methods. A kidney biopsy was performed, which showed that part of the cortical parenchyme was infiltrated by echinococcal protoscolices with hooklets. Because there were no cysts present on the graft, we concluded that disease was at an early stage. The patient was given albendazole for 3 months. After therapy, all echinococcal structures disappeared. Her creatinine level dropped to baseline, and proteinuria resolved. Echinococcal disease can affect transplanted kidneys. Albendazole is a valuable treatment option for patients who are not candidates for surgical resection.
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    The Influence of Polyomavirus Infected Glomerular Cells on the Development of Glomerulopathy and the Graft Survival
    (2018) Ozdemir, B. Handan; Terzi, Aysen; Ayva, Sebnem; Akcay, Eda; Atilgan, Alev Ok; Soy, Ebru H. Ayvazoglu; Acar, F. Nurhan Ozdemir; Moray, Gokhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-1225-1320; 0000-0002-2280-8778; 0000-0001-6831-9585; 0000-0001-8595-8880; 0000-0002-0993-9917; 0000-0002-5682-0943; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; F-7546-2013; AAK-1967-2021; AAK-1960-2021; AAK-3333-2021; AAC-5566-2019; AAK-1697-2021; AAE-1041-2021; AAJ-8097-2021
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    Nonmelanoma Skin Cancer After Kidney Transplant
    (2014) Tepeoglu, Merih; Ayva, Sebnem; Atilgan, Alev Ok; Tunca, M. Zeyneb; Ozdemir, B. Handan; Moray, Gokhan; Yildirim, Sedat; Arslan, Gulnaz; Haberal, Mehmet; https://orcid.org/0000-0002-9894-8005; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0001-8595-8880; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-5735-4315; https://orcid.org/0000-0002-3462-7632; 24907724; AAK-5222-2021; AAK-1967-2021; AAK-3333-2021; X-8540-2019; AAE-1041-2021; AAF-4610-2019; AAJ-8097-2021
    Objectives: Solid-organ transplant recipients have a high risk of developing nonmelanoma skin cancers. This study sought to determine the incidence of skin cancer and identify possible risk factors for skin cancer in kidney transplant recipients. Materials and Methods: Nonmelanoma skin cancer was diagnosed and confirmed with histology in 33 of 1275 kidney transplant recipients (2.6%). Demographic and clinical findings were reviewed retrospectively. Results: Nonmelanoma skin cancers included squamous cell carcinoma in 10 patients (30%), basal cell carcinoma in 9 patients (27%), Kaposi sarcoma in 9 patients (27%), squamous cell carcinoma in situ in 3 patients (9%), and cutaneous lymphoma in 2 patients (6%). The ratio of squamous cell carcinoma to basal cell carcinoma was 1.1:1. The mean time from transplant to skin cancer diagnosis was 65 +/- 55 months (range, 0-180 mo). Immunosuppressive therapy was based on cyclosporine in 22 patients (67%), tacrolimus in 8 patients (24%), and combination therapy (cyclosporine and azathioprine) in 3 patients (9%). Conclusions: Nonmelanoma skin cancer is an important clinical problem in kidney transplant recipients. Interventions that may benefit kidney transplant recipients may include intensive patient education, protection against sun exposure, and dermatologic screening programs.
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    Rearrangement of the Endothelial Cell Cytoskeleton in Glomerular and Peritubular Capillaries (PTCS) Following Antibody-Mediated Rejection (AMR): Its Significance on the Development of Transplant Glomerulopathy and Interstitial Fibrosis
    (2018) Ozdemir, B. Handan; Acar, F. Nurhan Ozdemir; Ayva, Sebnem; Akcay, Eda; Soy, Ebru H. Ayvazoglu; Ozdemir, Gokce; Haberal, Mehmet; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-3462-7632; AAL-4282-2020; AAK-1697-2021; AAK-1967-2021; AAK-1960-2021; AAC-5566-2019; AAL-4282-2020; AAJ-8097-2021
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    Renal Allograft With Calcium Oxalate Deposition: Association with Urinary Tract Infection and Development of Interstitial Fibrosis
    (2018) Ozdemir, B. Handan; Ayva, Sebnem; Ozdemir, Gokce; Atilgan, Alev Ok; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0003-2545-0078; 0000-0001-8595-8880; 0000-0002-5682-0943; 0000-0002-3462-7632; 29528009; X-8540-2019; AAK-1967-2021; AAL-4282-2020; AAK-3333-2021; AAK-1697-2021; AAJ-8097-2021
    Objectives: The interaction between calcium oxalate deposition and urinary tract infection is not well established. We aimed to identify the association between these and to determine the role of calcium oxalate deposition on interstitial fibrosis development. Materials and Methods: Renal allograft biopsies of 967 patients were reviewed to identify those with calcium oxalate deposition in the renal allograft, with 27 (2.8%) identified. Follow-up biopsies were conducted to reevaluate for calcium oxalate presence and interstitial fibrosis development. At time of biopsy, presence of urinary tract infection and oxaluria was also examined from medical records. Results: Mean time for development of calcium oxalate deposition in renal allografts was 1.7 +/- 0.4 and 32.7 +/- 21.6 months in patients with primary and secondary oxalosis, respectively (P < .001). Of 27 patients with calcium oxalate deposition, 7 (25.9%) showed tubulointerstitial nephritis, with 2 also having urinary tract infection. Four patients (14.8%) had only urinary tract infection. Causes of tubulointerstitial nephritis were secondary to bacterial infection in 2 and secondary to viral infection in 5 patients (2 polyomaviruses, 2 cytomegaloviruses, 1 adenovirus). Time until development of interstitial fibrosis after calcium oxalate deposition was 3.5 +/- 2.1 and 10.3 +/- 4.1 months in patients with primary and secondary oxalosis, respectively (P = .01). Time until graft loss after calcium oxalate deposition was 9.3 +/- 7.8 and 21.8 +/- 12 months in those with primary and secondary oxalosis (P < .001), with 1-, 3-, and 5-year kidney graft survival of 43%, 28%, and 0% and 100%, 100%, and 67% in those with primary and secondary oxalosis, respectively. Conclusions: Calcium oxalate deposits increased the risk of urinary tract infection and tubulointerstitial nephritis, with bacteria inducing increased presence of calcium oxalate deposition in a renal allograft. Calcium oxalate deposition had a significant influence on interstitial fibrosis development, therefore negatively affecting graft survival.
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    Renal Allograft with Calcium Oxalate Deposition: Its Association with Urinary Tract Infection and Development of Interstitial Fibrosis
    (2016) Ozdemir, Handan; Ozdemir, Gokce; Ayva, Sebnem; Ozdemir, Nurhan; Borcek, Pelin; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; AAL-4282-2020; AAK-1967-2021; AAK-1697-2021; AAE-1041-2021; AAJ-8097-2021
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    Sequential Biopsy Findings of Polyomavirus Associated Nephropathy
    (2016) Ozdemir, Handan; Ozdemir, Nurhan; Terzi, Aysen; Ayva, Sebnem; Akcay, Eda Yilmaz; Arslan, Hande; Ozdemir, Gokce; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-1225-1320; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0002-5708-7915; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; F-7546-2013; AAK-1967-2021; AAK-1960-2021; ABG-7034-2021; AAL-4282-2020; AAJ-8097-2021