Browsing by Author "Aydin, Makbule"

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    Relationship Between Interleukin-8 and the Oxidant-Antioxidant System in End-Stage Renal Failure Patients
    (Başkent Üniversitesi, 2007-06) Aydin, Makbule; Ozkok,Elif; Ozturk, Oguz; Agachan, Bedia; Yilmaz, Hulya; Yaylim, Ilhan; Kebabcioglu, Seher; Ispir, Turgay
    Objectives: We aimed to evaluate the relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients with and without diabetes mellitus undergoing regular hemodialysis treatment. Materials and Methods: Plasma levels of malondialdehyde and whole blood reduced glutathione were measured as markers of the oxidant and antioxidant systems, respectively. Plasma interleukin-8 levels were measured by enzyme-linked immunosorbent assay. Results: When compared with controls, plasma interleukin-8 levels were elevated in both diabetic and nondiabetic end-stage renal disease patients. Plasma malondialdehyde levels were statistically significantly higher in end-stage renal disease patients with and without diabetes mellitus than they were in controls; however, reduced glutathione levels were statistically significantly lower in diabetic and nondiabetic end-stage renal disease patients than they were controls. Conclusions: In end-stage renal disease patients with and without diabetes mellitus, elevated interleukin-8 levels and decreased reduced glutathione levels may be attributed to increased oxidative stress due to inflammation. In other words, increased reactive oxygen species may induce interleukin-8 production and result in diminished reduced glutathione levels. Our data suggest a relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients.