Browsing by Author "Aydin, M."

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    Aflatoxin Levels in Chronic Hepatitis B Patients with Cirrhosis or Hepatocellular Carcinoma in Balkesir, Turkey
    (2015) Aydin, M.; Aydin, S.; Bacanli, M.; Basaran, N.; 0000-0003-4044-9366; 0000-0001-8581-8933; 0000-0002-6368-2745; 25894298; HLX-0937-2023; J-1104-2013; J-1114-2013
    Aflatoxins, the secondary metabolites produced by species of naturally occurring Aspergilli, are commonly found in food such as cereals, dried fruits and juice, wine, beer and spices. They are hepatotoxic and are well known human carcinogens based on evidence from human studies. Aflatoxins are an environmental risk factor for the development of hepatocellular carcinoma (HCC). Chronic hepatitis B-infected patients are at increased risk of cirrhosis, hepatic failure and liver cancer. This study was designed to determine the serum aflatoxin B-1 (AFB(1)), aflatoxin B-2 (AFB(2)), aflatoxin G(1) (AFG(1)) and aflatoxin G(2) (AFG(2)) concentrations using high-pressure liquid chromatography (HPLC) in hepatitis B-infected patients with or without cirrhosis and liver cancer, alongside healthy controls in Balkesir, Turkey. The mean AFB(1) and total AF levels in patients without liver cancer and cirrhosis were significantly higher than healthy controls. The mean AFB(1) and total AF levels in patients with chronic hepatitis B and HCC were significantly higher than infected patients with or without cirrhosis. These results suggest that patients with chronic hepatitis B who are exposed to AFs are at increased risk for developing HCC, which might be prevented by reducing consumption of contaminated foods.
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    Healthcare-Associated Gram-Negative Bloodstream Infections: Antibiotic Resistance and Predictors Of Mortality
    (2016) Ergonul, O.; Aydin, M.; Azap, A.; Basaran, S.; Tekin, S.; Kaya, S.; Gulsun, S.; Yoruk, G.; Kursun, E.; Yesilkaya, A.; Simsek, F.; Yilmaz, E.; Bilgin, H.; Hatipoglu, C.; Cabadak, H.; Tezer, Y.; Togan, T.; Karaoglan, I.; Inan, A.; Engin, A.; Aliskan, H. E.; Yavuz, S. S.; Erdinc, S.; Mulazimoglu, L.; Azap, O.; Can, F.; Akalin, H.; Timurkaynak, F.; https://orcid.org/0000-0003-4044-9366; https://orcid.org/0000-0001-9060-3195; 27717604; HLX-0937-2023; AAE-2282-2021
    This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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    Rapid Emergence of Colistin Resistance and Its Impact on Fatality Among Healthcare-Associated Infections
    (2018) Aydin, M.; Ergonul, O.; Azap, A.; Bilgin, H.; Aydin, G.; Cavus, S. A.; Demiroglu, Y. Z.; Aliskan, H. E.; Memikoglu, O.; Menekse, S.; Kaya, S.; Demir, N. A.; Karaoglan, I.; Basaran, S.; Hatipoglu, C.; Erdinc, S.; Yilmaz, E.; Tumturk, A.; Tezer, Y.; Demirkaya, H.; Cakar, S. E.; Keske, S.; Tekin, S.; Yardimci, C.; Karakoc, C.; Ergen, P.; Azap, O.; Mulazimoglu, L.; Ural, O.; Can, F.; Akalin, H.; https://orcid.org/0000-0003-4044-9366; 29248504; HLX-0937-2023
    This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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    THE ROLE OF CYCLOPHOSPHAMIDE CHEMOTHERAPY IN THE TREATMENT OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS
    (2020) Bitik, B.; Aydin, M.; Dalgic, G. Sahin; Kaskari, D.; Yucel, A. E.; 0000-0001-5803-915X; 0000-0002-0125-8746; AAI-9195-2021; H-7637-2016