Browsing by Author "Avci, Begum"

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Association Between Vitamin D Deficiency and Anemia in Pediatric Kidney Transplant Recipients
(2022) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Yilmaz, Aysun Caltik; Karakaya, Emre; Moray, Gokhan; Haberal, Mehmet; 0000-0003-1434-3824; 0000-0002-3462-7632; 0000-0002-4879-7974; 0000-0003-0774-4419; 35570598; AAJ-8833-2021; AAJ-8097-2021; AAD-5466-2021; AAD-1877-2021
Objectives: The association between vitamin D deficiency and anemia is known. Vitamin D deficiency and anemia are common in kidney transplant recipients. We examined the relationship between vitamin D levels and anemia in pediatric kidney transplant recipients. Materials and Methods: We reviewed retrospectively the data of 75 pediatric kidney transplant recipients (0-18 years of age). Patients were evaluated in 3 groups according to serum 25-hydroxyvitamin D levels (<20, 20-30, and >30 ng/mL) in the first year posttransplant: group 1 was the vitamin D deficiency group, group 2 was the vitamin D insufficiency group, and group 3 was normal vitamin D level group, respectively. Groups were compared in terms of anemia parameters, calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels, as well as infection, rejection, and graft loss status. All patients included in the study were grouped as those with anemia and without anemia, and the 2 groups were compared in terms of vitamin D levels, serum parathyroid hormone values, estimated glomerular filtration rate, and infection, rejection, and graft loss status. Results: There were 41 patients (54.7%) in group 1, 24 patients (32%) in group 2, and 10 patients (13%) in group 3. There were 65 patients (86.7%) with vitamin D deficiency/insufficiency. When groups were compared, the hematocrit level was found to be lower in groups 1 and 2 (P < .05) and ferritin level was found to be lower in group 1 (P < .05). Anemia was present in 20 patients (26.6%): 61% of patients with anemia had vitamin D deficiency and 33% had vitamin D insufficiency (P > .05). In total, 94% of patients with anemia had vitamin D deficiency/insufficiency. Conclusions: Vitamin D deficiency/insufficiency is common in pediatric kidney transplant recipients. Vitamin D levels should be measured, especially in all kidney transplant recipients with persistent anemia. Thus, risk factors associated anemia can be reduced by treating the deficiency/insufficiency.
Association Between Vitamin D Deficiency and Anemia in Pediatric Renal Transplant Recipients
(2022) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Yilmaz, Aysun Caltik; Karakaya, Emre; Moray, Gokhan; Haberal, Mehmet; 0000-0003-1434-3824; 0000-0002-5375-379X; 0000-0002-3462-7632; 0000-0002-4879-7974; AAJ-8833-2021; GYU-5220-2022; AAJ-8097-2021; AAD-5466-2021
Association Of Pediatric Vasculitis Activity Score With Immunoglobulin A Vasculitis With Nephritis
(2023) Avci, Begum; Kurt, Tuba; Aydin, Fatma; Celikel, Elif; Tekin, Zahide Ekinci; Sezer, Muge; Tekgoz, Nilufer; Karagol, Cuneyt; Coskun, Serkan; Kaplan, Melike Mehves; Bayrakci, Umut Selda; Acar, Banu; https://orcid.org/0000-0002-5375-379X; 35895124
Background Immunoglobulin A vasculitis with nephritis (IgAVN) is the most serious complication affecting long-term prognosis. Understanding the risk factors and markers for the development of IgAVN is essential. The aim of this study is to identify IgAVN-associated factors and to evaluate the usability of Pediatric Vasculitis Activity Score (PVAS) at diagnosis as an early marker for the development of IgAVN. Methods We conducted a retrospective case-control study of 314 patients divided into two groups: those with nephritis (IgAVN) and without nephritis (non-IgAVN). The groups were compared in terms of clinical symptoms, laboratory values, and PVAS values. Results In total, 18.5% of the patients had IgAVN; they were older than the non-IgAVN patients (median age was 8.8, p < 0.05). Arthritis/arthralgia, abdominal pain, and intestinal bleeding were more common, systolic and diastolic BP were higher in IgAVN (p < 0.05). CRP, serum creatinine, and urine protein/Cr, PVAS were higher, while serum albumin was lower in IgAVN (p < 0.05). The receiver operator characteristic curve (ROC) analysis showed that IgAV patients with a determined cut-off PVAS value greater than 3 had 70.7% sensitivity in predicting whether or not they would develop IgAVN. Logistic regression analysis found that PVAS > 3 and low serum albumin at the time of diagnosis were independent risk factors for IgAVN. Conclusion Our study revealed that PVAS > 3 at diagnosis is an independent predictor of IgAVN. Patients with PVAS > 3 should be followed more closely to ensure early diagnosis and management of IgAVN.
BK Polyomavirus Infection and Risk Factors in Pediatric Patients Undergoing Kidney Transplant
(2022) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Ecevit, Zafer; Soy, Ebru Ayvazoglu; Moray, Gokhan; Haberal, Mehmet; 35570612
Objectives: BK polyomavirus infection is a critical complication affecting graft survival after kidney transplant. We aimed to determine the frequency, the effect on graft function, and the risk factors of BK polyomavirus infection in pediatric kidney transplant patients. Materials and Methods: We retrospectively reviewed data of 144 pediatric patients (female/male: 67/77; 0-18 years of age) who received kidney transplants in the past 10 years at our center. Demographic/laboratory data, kidney failure etiologies, donor types, and immunosuppressive treatments were recorded. Patients were grouped as those with and without BKV infection, with groups compared in terms of transplant age, sex, kidney failure etiology, donor type, immunosuppressive treatments, presence of ureteral stents, acute rejection episodes, accompanying viral infections, glomerular filtration rate, and graft loss rate. Results: Twelve patients (8.3%) had BK polyomavirus infection. All 12 patients had viruria (8.3%), 8 (5.5%) had viremia, and 4 (2.8%) had BK polyomavirus nephropathy. Two patients (1.4%) had graft loss because of BK polyomavirus nephropathy. When patients with and without infection were compared, no significant differences were found in terms of sex, transplant age, donor type, presence of a ureteral stent, acute rejection, graft loss, or immunosuppressive treatment (P > .05). Rates of congenital anomalies of the kidney and urinary tract were 30.3% and 66.6% in those without and with BK polyomavirus infection, respectively (P < .05). The group positive for BK polyomavirus had a significantly higher incidence of cytomegalovirus infection versus the group without infection (P < .05). Glomerular filtration rate values at years 1 and 3 were similar between groups (P > .05). Conclusions: Frequency of BK polyomavirus nephropathy in pediatric patients undergoing kidney transplant in our center was consistent with data from other centers. Graft loss can be prevented by early detection and treatment through close periodic control and adequate evaluation of risk factors.
The Clinical Characteristics and Prognosis of Exon 2 Mutations in Familial Mediterranean Fever
(2023) Avci, Begum; Parmaksiz, Gonul; Sahin, Feride; Noyan, Aytul; 0000-0001-7308-9673; AAC-7232-2020
Objective: It is unclear whether exon 2 mutations are variations or mutations that causes the disease. This study aimed to evaluate the clinical features and prognosis exon 2 mutations in Familial Mediterranean Fever. Methods: The clinical features, disease severity and prognosis of all patients with at least one exon 2 mutations were evaluated retrospectively. These data were compared separately for homozygous (Group 1), heterozygous (Group 2), compound heterozygous (Group 3), and complex alleles (Group 4), and the data were compared by grouping patients into those with and without exon 10 mutations. Results: There were a total of 119 patients with exon 2 mutations, including 11.7% in Group 1, 36.1% in Group 2, 21.8% in Group 3, and 30.2% in Group 4 were similar in terms of demographic data, clinical characteristics, and disease course. When compared patients with exon 10 mutations (+) to those with exon 10 mutations (-), the exon 10 mutations (+) group had a higher presence of chest pain (100%, p = 0.02) and a significantly higher mean Pras severity score (6.66 +/- 1.87, 6.01 +/- 1.40; p=0.02). Additionally, a higher number of patients with exon 10 mutation (-) achieved remission with treatment (76 (67.9%), 36 (32.1%); p = 0.03). Conclusion: Exon 2 mutations have a milder course and higher remission rates but they should be considered as Familial Mediterranean Fever disease because of their similar clinical presentation and response to colchicine treatment with exon 10 mutations. Early treatment and close follow- up should be performed.
Eculizumab in the Treatment of Dense Deposit Disease
(2015) Gulleroglu, Kaan; Avci, Begum; Kantar, Asli; Ozdemir, Handan; Baskin, Esra; 0000-0002-5375-379X; 0000-0003-1434-3824; 0000-0002-7528-3557; 0000-0003-1434-3824; 0000-0003-4361-8508; GYU-5220-2022; AAJ-8833-2021; X-8540-2019; F-3294-2013; B-5785-2018
The Effect of Pretransplant Long Term Anuria on Graft Outcome in Children
(2017) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Kazanci, Ozlem; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; 0000-0003-1434-3824; 0000-0003-4361-8508; 0000-0003-1434-3824; 0000-0002-3462-7632; 0000-0002-5375-379X; 0000-0003-2498-7287; F-3294-2013; AAH-9198-2019; B-5785-2018; AAJ-8833-2021; AAJ-8097-2021; GYU-5220-2022; AAE-1041-2021
Effects of Early Post-Transplant Blood Transfusion on Graft Outcome in Pediatric Renal Transplant Recipients
(2018) Kazanci, Ozlem; Baskin, Esra; Gulleroglu, Kaan; Avci, Begum; Soy, Ebru H. Ayvazoglu; Sahin, Vildan; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0003-4361-8508; ttps://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0002-5375-379X; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; B-5785-2018; AAJ-8833-2021; GYU-5220-2022; AAC-5566-2019; AAE-1041-2021; AAJ-8097-2021
Effects of Early Post-Transplant Blood Transfusion on Graft Outcome in Pediatric Renaltransplant Recipients
(2018) Kazanci, Ozlem; Baskin, Esra; Gulleroglu, Kaan; Sahin, Vildan; Avci, Begum; Toy, Ebru Ayvazoglu; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; 0000-0003-1434-3824; 0000-0002-5375-379X; 0000-0003-2498-7287; 0000-0002-3462-7632; B-5785-2018; F-3294-2013; GYU-5220-2022; AAE-1041-2021; AAJ-8097-2021
The Effects of Graft Weight Oon Allograft Outcomes in Children with Renal Transplant Recipients
(2018) Baskin, Esra; Gulleroglu, Kaan; Sahin, Vildan; Kazanci, Ozlem; Avci, Begum; Toy, Ebru Ayvazoglu; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; 0000-0003-1434-3824; 0000-0002-5375-379X; 0000-0003-2498-7287; 0000-0002-3462-7632; B-5785-2018; F-3294-2013; GYU-5220-2022; AAE-1041-2021; AAJ-8097-2021
Effects of Renal Transplant Age on The Graft Functions in Pediatric Transplant Patients
(2016) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0002-5375-379X; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; GYU-5220-2022; B-5785-2018; AAJ-8833-2021; AAH-9198-2019; AAE-1041-2021; AAJ-8097-2021
Improvement of Cardiac Functions After Renal Transplantation in Patients with Severe Cardiac Risk: Long Term Follow-Up
(2018) Baskin, Esra; Avci, Begum; Gulleroglu, Kaan; Kazanci, Ozlem; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; 0000-0002-5375-379X; 0000-0003-1434-3824; 0000-0003-2498-7287; 0000-0002-3462-7632; B-5785-2018; GYU-5220-2022; F-3294-2013; AAH-9198-2019; AAE-1041-2021; AAJ-8097-2021
Long-Term Outcomes of Kidney Transplant Recipients With Juvenile Nephronophthisis
(2022) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Yilmaz, Aysun Caltik; Kantar, Asli; Akdur, Aydincan; Moray, Gokhan; Haberal, Mehmet; 0000-0003-1434-3824; 0000-0003-0774-4419; 0000-0002-3462-7632; 35570616; AAJ-8833-2021; AAD-1877-2021; AAJ-8097-2021
Objectives: Nephronophthisis is the most common genetic cause of kidney failure in childhood. Treatment for nephronophthisis is symptomatic, and kidney transplant is a good treatment option when kidney failure has developed. We reported the outcomes of kidney transplant recipients with primary diagnosis of juvenile nephronophthisis who were followed-up in our center. Materials and Methods: We retrospectively examined medical records of 17 kidney transplant patients with a primary diagnosis of juvenile nephronophthisis. We compared this group of 17 patients with kidney transplant recipients who had other etiologies of kidney failure in terms of transplant age, donor type, immunosuppressive treatment, acute rejection, graft loss rates, and glomerular filtration rates at 1 and 5 years posttransplant (N = 180 total analyzed). Results: Among 180 kidney transplant recipients, the 17 patients (9.4%) with nephronophthisis had a mean age of 12.6 +/- 4.3 years and mean follow-up time posttransplant of 79.5 +/- 41.9 months. Five of 17 patients received a kidney transplant from a deceased donor (29.4%), and the remaining 12 patients (70.6%) received transplants from living related donors. Preemptive kidney transplant was performed in 4 patients (23.5%). There was a statistically significant difference (P < .05) in terms of acute rejection between patients with nephronophthisis (17.6%) versus patients with other primary diagnoses (34%). However, the patients with nephronophthisis versus those with other primary diagnoses were similar (P > .05) in terms of transplant age (12.6 +/- 4.3 vs 13.8 +/- 6.7 years, respectively) and follow-up time (79.5 +/- 41.9 vs 59.1 +/- 38.8 months, respectively). Donor type, immunosuppressive treatment, and 1-year (96.7 +/- 23.2 vs 97.6 +/- 28.4 mL/min/1.73 m(2)) and 5-year (84.7 +/- 31.1 vs 86.7 +/- 21.7 mL/min/1.73 m(2)) glomerular filtration rates were also similar (P > .05) between groups. Conclusions: Posttransplant prognosis was good among kidney transplant recipients with juvenile nephronophthisis.
Our Experience of Patients with Juvenile Nephronophthisis After Renal Transplantation
(2018) Avci, Begum; Kazanci, Ozlem; Baskin, Esra; Gulleroglu, Kaan; Akdur, Aydincan; Soy, Ebru H. Ayvazoglu; Moray, Gokhan; Haberal, Mehmet; 0000-0002-5375-379X; 0000-0003-4361-8508; 0000-0003-1434-3824; 0000-0002-8726-3369; 0000-0002-0993-9917; 0000-0003-2498-7287; 0000-0002-3462-7632; GYU-5220-2022; B-5785-2018; F-3294-2013; AAA-3068-2021; AAC-5566-2019; AAE-1041-2021; AAJ-8097-2021
Primary Focal Segmental Glomerulosclerosis Recurrence After Pediatric Renal Transplantation
(2022) Baskin, Esra; Avci, Begum; Gulleroglu, Kaan; Akdur, Aydincan; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0002-5375-379X; https://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0002-3462-7632; 35384808; GYU-5220-2022; AAJ-8833-2021; AAJ-8097-2021
Objectives: Focal segmental glomerulosclerosis recurrence after renal transplant occurs frequently in pediatric patients and is associated with poor graft survival when patients reach adulthood. We investigated recurrence rates, recurrence risk factors, management strategies, and long-term graft function among pediatric renal transplant recipients with focal segmental glomerulosclerosis as primary disease. Materials and Methods: We retrospectively evaluated medical records of 34 pediatric patients with primary focal segmental glomerulosclerosis who had undergone renal transplant between 2004 and 2019 at our center. Focal segmental glomerulosclerosis recurrence was diagnosed by the presence of nephrotic range proteinuria after transplant and confirmed by graft biopsy. Preoperative prophylactic plasma exchange was administered to pediatric renal transplant recipients with primary focal segmental glomerulosclerosis. Plasma exchange was also used to treat focal segmental glomerulosclerosis recurrence, with rituximab added if the patient did not respond to plasma exchange. Results: All patients (male-to-female ratio of 19:15) in our group underwent renal transplant. Mean patient age at the time of transplant was 12.72 +/- 5.46 years. Twenty-nine patients received livingrelated donor allografts (85.3%) and 5 received organs from deceased donors (14.7%). We identified focal segmental glomerulosclerosis recurrence in 5 recipients (14.7%). Time from focal segmental glomerulosclerosis diagnosis to end-stage renal disease and duration of dialysis were shorter in the recurrence group than in the nonrecurrence group (48.4 months [range, 2-90 mo] vs 65.1 months [range, 8-123 mo] and 1.41 +/- 0.82 vs 3.18 +/- 1.88 years, respectively; P <.05). Donor type and transplant age were similar in both groups. Of those with recurrence who had received plasma exchange and rituximab, 3 patients (75%) had complete remission and 1 patient (25%) had partial remission. Conclusions: Prophylactic plasma exchange and the combined plasma exchange-rituximab regimen for treatment of focal segmental glomerulosclerosis recurrence resulted in low recurrence and good remission rates in our pediatric cohort.
Prophylactic Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome in A Pediatric Renal Transplant Patient
(2015) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Kantar, Asli; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0003-4361-8508; 0000-0003-1434-3824; 0000-0003-2498-7287; 0000-0003-1434-3824; 0000-0002-5375-379X; AAJ-8097-2021; B-5785-2018; F-3294-2013; AAE-1041-2021; AAJ-8833-2021; GYU-5220-2022
The Rate of BK Virus Infection in Pediatric Renal Transplant Patients
(2018) Baskin, Esra; Avci, Begum; Gulleroglu, Kaan; Kazanci, Ozlem; Kantar, Asli; Ecevit, Zafer; Ozdemir, Handan; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; 0000-0002-5375-379X; 0000-0003-1434-3824; 0000-0002-7528-3557; 0000-0003-2498-7287; 0000-0002-3462-7632; B-5785-2018; GYU-5220-2022; AAJ-8833-2021; X-8540-2019; AAE-1041-2021; AAJ-8097-2021
Unusual eye findings in a patient with atypical hemolytic uremic syndrome: Answers
(2022) Avci, Begum; Ozdek, Sengul; Akkoyun, Imren; Baskin, Esra; 0000-0002-5375-379X; 0000-0002-2860-7424; 35084569; AAK-7713-2021
Unusual Eye Findings İn A Patient With Atypical Hemolytic Uremic Syndrome: Questions
(2022) Avci, Begum; Ozdek, Sengul; Akkoyun, Imren; https://orcid.org/0000-0002-5375-379X; https://orcid.org/0000-0002-2860-7424; 35084568; AAK-7713-2021